Patrick Fillingham
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View article: Increased hindbrain motion in Chiari I malformation patients measured through 3D amplified MRI (3D aMRI)
Increased hindbrain motion in Chiari I malformation patients measured through 3D amplified MRI (3D aMRI) Open
Chiari Malformation type 1 (CM-I) is a neurological disorder characterized by morphological defects including excessive cerebellar tonsillar ectopia and associated manifestations. We used 3D amplified MRI on a cohort of healthy and CM-I su…
View article: Intracranial aneurysm wall displacement depicted by amplified Flow predicts growth
Intracranial aneurysm wall displacement depicted by amplified Flow predicts growth Open
Background Abnormal intracranial aneurysm (IA) wall motion has been associated with IA growth and rupture. Recently, a new image processing algorithm called amplified Flow (aFlow) has been used to successfully track IA wall motion by combi…
View article: Standardized viscosity as a source of error in computational fluid dynamic simulations of cerebral aneurysms
Standardized viscosity as a source of error in computational fluid dynamic simulations of cerebral aneurysms Open
Background Computational fluid dynamics (CFD) simulations are a powerful tool for studying cerebral aneurysms, capable of evaluating hemodynamics in a way that is infeasible with imaging alone. However, the difficulty of incorporating pati…
View article: Increased Hindbrain Motion in Chiari I Malformation Patients Measured Through 3D Amplified MRI (3D aMRI)
Increased Hindbrain Motion in Chiari I Malformation Patients Measured Through 3D Amplified MRI (3D aMRI) Open
Chiari Malformation type 1 (CM-I) is a neurological disorder characterized by morphological defects including excessive cerebellar tonsillar ectopia and associated manifestations. We used 3D amplified MRI on a cohort of healthy and CM-I su…
View article: Noninvasive, patient-specific computational fluid dynamics simulations of dural venous sinus pressures in idiopathic intracranial hypertension
Noninvasive, patient-specific computational fluid dynamics simulations of dural venous sinus pressures in idiopathic intracranial hypertension Open
Background: The pathophysiology of Idiopathic Intracranial Hypertension (IIH) is poorly understood, making the disease difficult to properly diagnose and treat. Endovascular venous stenting has emerged as an effective non-invasive treatmen…
View article: P-016 Lagrangian trajectory simulations with synchrotron microtomography improves hemodynamic analysis of intracranial aneurysms treated with flow diverting stents
P-016 Lagrangian trajectory simulations with synchrotron microtomography improves hemodynamic analysis of intracranial aneurysms treated with flow diverting stents Open
Background Successful treatment of cerebral aneurysms with flow diverting stents (FDS) depends upon altering biomechanical forces to precipitate stable thrombus formation. Computational fluid dynamics (CFD) simulations can model such force…
View article: O-071 Estimation of optimal coil packing density using lagrangian particle tracking
O-071 Estimation of optimal coil packing density using lagrangian particle tracking Open
Background Aneurysm coil packing density has been studied as a surrogate for treatment outcome, but clinical results are conflicting. Previous work applying computational fluid dynamics simulations to coil embolization of cerebral aneurysm…
View article: Improving Computational Fluid Dynamics Simulations of Coiled Aneurysms Using Finite Element Modeling
Improving Computational Fluid Dynamics Simulations of Coiled Aneurysms Using Finite Element Modeling Open
Cerebral aneurysms are a serious clinical challenge, with ∼half resulting in death or disability. Treatment via endovascular coiling significantly reduces the chances of rupture, but the technique has failure rates between 25-40%. This pre…
View article: Increased Hindbrain Motion in Chiari Malformation I Patients Measured Through 3D Amplified MRI (3D aMRI)
Increased Hindbrain Motion in Chiari Malformation I Patients Measured Through 3D Amplified MRI (3D aMRI) Open
Chiari Malformation type 1 (CM-I) is a neurological disorder characterized by morphological defects such as excessive cerebral tonsils herniation and vast associated symptomatology. Given that these structural defects cannot explain the un…
View article: Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms
Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms Open
Successful occlusion of cerebral aneurysms using coil embolization is contingent upon stable thrombus formation, and the quality of the thrombus depends upon the biomechanical environment. The goal of this study was to investigate how coil…
View article: Model for Wall Shear Stress from Obliquely Impinging Planar Underexpanded Jets
Model for Wall Shear Stress from Obliquely Impinging Planar Underexpanded Jets Open
Though inclined under-expanded planar jets are used in many practical applications, the wall stress resulting from their impingement has not been adequately characterized. Reduced-order models for wall shear as a function of jet parameters…
View article: E-177 Machine learning model for the prediction of patient-specific waveforms of blood flowthrough the internal carotid artery
E-177 Machine learning model for the prediction of patient-specific waveforms of blood flowthrough the internal carotid artery Open
Introduction Computational fluid dynamics (CFD) is an excellent tool for studying cerebral aneurysms as the formation, growth, and rupture of these aneurysms are heavily influenced by complex hemodynamic variables that cannot be measured i…
View article: P-011 Patient-specific computational simulation of IIH patients for determining eligibility for venous sinus stenting
P-011 Patient-specific computational simulation of IIH patients for determining eligibility for venous sinus stenting Open
Introduction Endovascular venous stenting has emerged as an effective non-invasive treatment option for a select cohort of Idiopathic Intracranial Hypertension (IIH) patients with venous sinus stenosis and elevated venous sinus pressure gr…
View article: Intracranial Aneurysm Wall Displacement Predicts Instability
Intracranial Aneurysm Wall Displacement Predicts Instability Open
Ruptured intracranial aneurysms (IAs) are catastrophic events associated with a high mortality rate. An estimation of 6 million people in the United States have reported IAs, raising a pressing need for diagnostic tools to assess IAs ruptu…
View article: Similarity of the Wall Jet Resulting from Planar Underexpanded Impinging Jets
Similarity of the Wall Jet Resulting from Planar Underexpanded Impinging Jets Open
Wall shear stress is mapped across nozzle parameters (stand-off height, jet hydraulic diameter, and nozzle pressure ratio) for two dimensional planar underexpanded impinging jets. Computational fluid dynamics is used to calculate the flow …
View article: Nondimensional Parameter for Characterization of Wall Shear Stress From Underexpanded Axisymmetric Impinging Jets
Nondimensional Parameter for Characterization of Wall Shear Stress From Underexpanded Axisymmetric Impinging Jets Open
Wall shear stress is characterized for underexpanded axisymmetric impinging jets for the application of aerodynamic particle resuspension from a surface. Analysis of the flow field resulting from normally impinging axisymmetric jets is con…