Patrick Flannery
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View article: 3D multimodal histological atlas and coordinate framework for the mouse brain and head
3D multimodal histological atlas and coordinate framework for the mouse brain and head Open
Brain reference atlases are essential for neuroscience experiments and data integration. However, histological atlases of the mouse brain, crucial in biomedical research, have not kept pace. Autofluorescence-based volumetric brain atlases …
View article: 3D multimodal histological atlas and coordinate framework for the mouse brain and head
3D multimodal histological atlas and coordinate framework for the mouse brain and head Open
Brain reference atlases are essential for neuroscience experiments and data integration. However, histological atlases of the mouse brain, crucial in biomedical research, have not kept pace. Autofluorescence-based volumetric brain atlases …
View article: Supplemental Table 1 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplemental Table 1 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
Upstream regulators predicted in Ingenuity Pathway Analysis. All significant p<0.01) patient sample and cell line upstream regulators predicted to have changed after exposure to BRAFi, organized by tab. Analysis was conducted per-patient, …
View article: Supplementary Methods from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplementary Methods from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
Supplementary Methods
View article: Supplemental Table 2 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplemental Table 2 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
GSEA analysis of paired RNA samples. Samples were analyzed using both the C2 (Curated Gene Sets) and C6 (Oncogenic Signature Gene Sets) MSigDB Collections. Comparisons were made either between the pre- and post-BRAFi samples within the TGF…
View article: Supplementary Figure 3 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplementary Figure 3 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
Increased RTK expression and activity in AM38 resistant cells. (A) RTK array for parental (left) and resistant (right) AM38 cells. (B) Immunoblot of cell lysates from parental (P) and resistant (R) AM38. (C) Fold change in RNA expression b…
View article: Supplementary Figure 2 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplementary Figure 2 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
Frequency of co-mutations in BRAF and genes of interest in 35,231 patients in pan-cancer cohorts found in cBioPortal. The bar graph represents the number of patients with each pair of alterations as found in dataset and the circles represe…
View article: Supplemental Table 3 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplemental Table 3 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
GSEA subgroup analysis of paired RNA samples. Subgroups were analyzed based on the presence (Enriched in post-txt mutant) or absence (Enriched in post-txt non-mutant) of a genomic alteration at time of recurrence. Subgroup analysis was als…
View article: Supplementary Figure 1 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplementary Figure 1 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
Venn diagram detailing the gene lists used to assemble the ten most commonly mutated genes in glioblastoma.
View article: Data from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Data from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
Purpose:Selective RAF-targeted therapy is effective in some patients with BRAFV600E-mutated glioma, though emergent and adaptive resistance occurs through ill-defined mechanisms.Experimental Design:Paired pre-/post- RAF inhibitor (RAFi)-tr…
View article: Supplementary Figure 4 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma
Supplementary Figure 4 from Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF<sup>V600E</sup>-Mutant Human Glioma Open
GSEA comparing paired pre-/post- treatment glioma with BRAF V600E mutations (n=10) against BRAF wild type (n = 4) specimens. Highlighted are selected groups of similar differentially expressed gene sets. WT = wild type
View article: A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease
A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease Open
Background Diffuse midline glioma (DMG) is an aggressive pediatric central nervous system tumor with strong metastatic potential. As localized treatment of the primary tumor improves, metastatic disease is becoming a more important factor …
View article: Data from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Data from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
High-grade glioma (HGG) is the leading cause of cancer-related death among children. Selinexor, an orally bioavailable, reversible inhibitor of the nuclear export protein, exportin 1, is in clinical trials for a range of cancers, including…
View article: Supp. Methods from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Methods from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Supplemental Methods
View article: Supp. Figures from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Figures from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Supplemental Figures 1 - 6
View article: Data from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Data from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
High-grade glioma (HGG) is the leading cause of cancer-related death among children. Selinexor, an orally bioavailable, reversible inhibitor of the nuclear export protein, exportin 1, is in clinical trials for a range of cancers, including…
View article: Supp. Table 3 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Table 3 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Summary of p-NF-KB and NF-KB values and ratios from Figure 1f, h and i
View article: Supp. Methods from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Methods from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Supplemental Methods
View article: Supp. Table 2 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Table 2 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
NCI approved anti-cancer agents in combination drug screen with selinexor
View article: Supp. Table 2 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Table 2 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
NCI approved anti-cancer agents in combination drug screen with selinexor
View article: Supp. Table 1 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Table 1 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Cell line characteristics and selinexor in vitro IC50 levels
View article: Supp. Table 3 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Table 3 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Summary of p-NF-KB and NF-KB values and ratios from Figure 1f, h and i
View article: Supp. Figures from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Figures from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Supplemental Figures 1 - 6
View article: Supp. Table 1 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma
Supp. Table 1 from Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma Open
Cell line characteristics and selinexor in vitro IC50 levels
View article: Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes
Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes Open
During multidrug combination chemotherapy, activation of the nuclear receptor and the transcription factor human pregnane xenobiotic receptor (hPXR) has been shown to play a role in the development of chemoresistance. Mechanistically, this…
View article: Interplay between the Cannabinoid System and microRNAs in Cancer
Interplay between the Cannabinoid System and microRNAs in Cancer Open
Cancer patients often use cannabinoids for alleviating symptoms induced by cancer pathogenesis and cancer treatment. This use of cannabinoids can have unexpected effects in cancer patients depending on the cancer type, resulting in either …
View article: Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report Open
Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis has been reported after SARS-CoV-2 infection, but not after SARS-CoV-2 vaccination. We report the first known case of anti-NMDAR encephalitis after SARS-CoV-2 immunization…
View article: <i>Oroxylum indicum</i> Extract, at a Physiologically Relevant Dosage, Does Not Induce Hepatotoxicity in C57BL/6J Mice
<i>Oroxylum indicum</i> Extract, at a Physiologically Relevant Dosage, Does Not Induce Hepatotoxicity in C57BL/6J Mice Open
Background Botanical supplements have been proven to provide beneficial health effects. However, they can induce unintended adverse events such as hepatotoxicity. Oroxylum indicum extract (OIE, Sabroxy ® ) has several health benefits inclu…