Patrick Fleming
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View article: Estimates of congenital cytomegalovirus‐attributable infant mortality in high‐income countries: A review
Estimates of congenital cytomegalovirus‐attributable infant mortality in high‐income countries: A review Open
As many as 5%–10% of infants with symptomatic congenital cytomegalovirus (cCMV) disease, or 0.4%–0.8% of all liveborn infants with cCMV infection, die in early infancy in high‐income countries. However, estimates are uncertain due to sever…
View article: Top 10 research priorities for cutaneous squamous cell carcinoma: results of the Skin Investigation Network of Canada Priority Setting Initiative
Top 10 research priorities for cutaneous squamous cell carcinoma: results of the Skin Investigation Network of Canada Priority Setting Initiative Open
The Skin Investigation Network of Canada (SkIN Canada) completed a national priority-setting initiative to identify the top 10 knowledge uncertainties for SCC based on the James Lind Alliance principles. Overall, 64 patients, clinicians an…
View article: The Acne Education Project: An educational initiative to improve acne health literacy and promote help‐seeking behavior in young adolescents
The Acne Education Project: An educational initiative to improve acne health literacy and promote help‐seeking behavior in young adolescents Open
Background Acne vulgaris is an inflammatory skin condition that is associated with poor acne health literacy. Diminished acne health literacy leads to delays in the access of health care, resulting in mismanagement, disfigurement, and psyc…
View article: Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization
Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization Open
Cetylpyridinium chloride (CPC) is an antimicrobial used in numerous personal care and janitorial products and food for human consumption at millimolar concentrations. Minimal information exists on the eukaryotic toxicology of CPC. We have …
View article: Sleep Disturbances in Children With Atopic Dermatitis: A Scoping Review
Sleep Disturbances in Children With Atopic Dermatitis: A Scoping Review Open
Atopic dermatitis (AD) is associated with various quality of life concerns including poor sleep. Sleep impairments in children with AD are associated with increased risk of short stature, metabolic syndrome, mental illness and neurocogniti…
View article: Treatments for Primary Delusional Infestation: Systematic Review
Treatments for Primary Delusional Infestation: Systematic Review Open
Background Delusional infestation, also known as Ekbom syndrome, is a rare delusional disorder characterized by the fixed belief that one is infested with parasites, worms, insects, or other organisms. Although delusional infestation is a …
View article: Treatments for Primary Delusional Infestation: Systematic Review (Preprint)
Treatments for Primary Delusional Infestation: Systematic Review (Preprint) Open
BACKGROUND Delusional infestation, also known as Ekbom syndrome, is a rare delusional disorder characterized by the fixed belief that one is infested with parasites, worms, insects, or other organisms. Although delusional infestation is a…
View article: Sacituzumab Govitecan for Treatment of Refractory Triple-Negative Metastatic Breast Cancer
Sacituzumab Govitecan for Treatment of Refractory Triple-Negative Metastatic Breast Cancer Open
Sacituzumab govitecan was initially approved in April 2020 under accelerated approval for the treatment of patients with metastatic triple-negative breast cancer who received at least two prior therapies for metastatic disease. A confirmat…
View article: The Impact of Acne Treatment on Skin Bacterial Microbiota: A Systematic Review
The Impact of Acne Treatment on Skin Bacterial Microbiota: A Systematic Review Open
Background Microbial strains such as Cutibacterium acnes have been examined as contributors to the pathogenesis of acne. Given the prevalence of the disease among adolescents and adults, the overutilization of antimicrobial agents may bree…
View article: The COVID-19 pandemic and its skin effects
The COVID-19 pandemic and its skin effects Open
The COVID-19 pandemic has increased rates of dermatologic conditions through direct infection, behavioural changes, and association with psychosocial factors. As the incidence of COVID-19 increases, family physicians should be well equippe…
View article: Characteristics of E-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) Patients.
Characteristics of E-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) Patients. Open
During August-December 2019, 23 persons who received a diagnosis of e-cigarette, or vaping, product use-associated lung injury (EVALI) were reported to the Arkansas Department of Health (ADH); none died. Among Arkansas EVALI patients, most…
View article: Severe Acute Respiratory Syndrome Coronavirus 2 and the Use of Biologics in Patients With Psoriasis
Severe Acute Respiratory Syndrome Coronavirus 2 and the Use of Biologics in Patients With Psoriasis Open
Coronavirus disease (COVID-19), a respiratory disease caused by a novel coronavirus designated severe acute respiratory syndrome coronavirus 2, has rapidly spread worldwide and has been recognized as a pandemic by the World Health Organiza…
View article: Diagnosis and Management of Atopic Dermatitis for Primary Care Providers
Diagnosis and Management of Atopic Dermatitis for Primary Care Providers Open
In this clinical review, we describe the pathophysiology, epidemiology, diagnosis, and treatment of AD, specifically highlighting commonly used therapies and novel medications.
View article: Research for city practice
Research for city practice Open
CITY KNOW-HOW: Worrying trends in terms of human health and planetary health are receiving increasing global concern. City leadership, planning and development all place the constraints on urban behaviours and lifestyles, usually accelerat…
View article: Use of community support and health services in an age-friendly city: the lived experiences of the oldest-old
Use of community support and health services in an age-friendly city: the lived experiences of the oldest-old Open
Increases in population ageing and urbanization have led to the development of age-friendly cities (AFC). While much has been done to integrate the needs of younger, healthier older adults, little research has examined the needs of the old…
View article: OPTIMIZING COMMUNITY SUPPORT FOR THE OLDEST-OLD IN AGE-FRIENDLY CITY DEVELOPMENT
OPTIMIZING COMMUNITY SUPPORT FOR THE OLDEST-OLD IN AGE-FRIENDLY CITY DEVELOPMENT Open
1 Focal group with people with dementia.1 Focal group with relatives of people with dementia.3 Interviews with experts in dementia (1 geriatrician and 2 psychologists)The result is Basque Country Age-friendly Business Guide.This educationa…