Patrick Frey
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View article: Analytical Comparison of Commonly Used Laboratory-Developed Tests for the Assessment of Ki-67 in Breast Carcinoma With a Food and Drug Administration–Approved Benchmark
Analytical Comparison of Commonly Used Laboratory-Developed Tests for the Assessment of Ki-67 in Breast Carcinoma With a Food and Drug Administration–Approved Benchmark Open
Ki-67 immunohistochemistry (IHC), a commonly used assay for breast cancer risk prognostication, has significant interlaboratory heterogeneity. This study assessed the impact of antibody clones by comparing the Ki-67 IHC MIB-1 pharmDx assay…
View article: Augmented reality microscopy to bridge trust between AI and pathologists
Augmented reality microscopy to bridge trust between AI and pathologists Open
Diagnostic certainty is the cornerstone of modern medicine and critical for maximal treatment benefit. When evaluating biomarker expression by immunohistochemistry (IHC), however, pathologists are hindered by complex scoring methodologies,…
View article: 66P Evaluation of an artificial intelligence algorithm for automated PD-L1 CPS scoring in triple-negative breast cancer across institutions, scanners, and antibody clones
66P Evaluation of an artificial intelligence algorithm for automated PD-L1 CPS scoring in triple-negative breast cancer across institutions, scanners, and antibody clones Open
In advanced triple-negative breast cancer (TNBC), assessment of the PD-L1 status is essential to identify patients that would benefit from immunotherapy. PD-L1 is routinely evaluated by combined positivity scoring (CPS) on immunohistochemi…
View article: Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1
Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1 Open
Epithelial-mesenchymal transition (EMT) is a pivotal process in development and disease. In carcinogenesis, various signaling pathways are known to trigger EMT by inducing the expression of EMT transcription factors (EMT-TFs) like SNAIL1, …
View article: SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferation
SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferation Open
The transcription factor SNAIL1 is a master regulator of epithelial‐to‐mesenchymal transition (EMT), a process entailing massive gene expression changes. To better understand SNAIL1‐induced transcriptional reprogramming we performed time‐r…
View article: The Symbiosis of Distributed Ledger and Machine Learning as a Relevance for Autonomy in the Internet of Things
The Symbiosis of Distributed Ledger and Machine Learning as a Relevance for Autonomy in the Internet of Things Open
The Internet of Things (IoT) describes the fusion of the physical and digital world which enables assets on the edge to send data to a platform where it gets analyzed. Defined actions are then triggered to influence cross-functional edge a…