Patrick G. Dean
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View article: Outcomes of Older Primary Kidney Transplant Recipients by Induction Agent and High-risk Viral Discordance Status in the United States
Outcomes of Older Primary Kidney Transplant Recipients by Induction Agent and High-risk Viral Discordance Status in the United States Open
Background. The impact of induction type or high-risk viral discordance on older kidney transplant recipients is unclear. Herein, we analyzed the association between induction type, viral discordance, and outcomes for older recipients. Met…
View article: BK polyomavirus DNAemia in pancreas transplant recipients compared to pancreas–kidney recipients
BK polyomavirus DNAemia in pancreas transplant recipients compared to pancreas–kidney recipients Open
Background BK polyomavirus (BKV) infection is a common complication of kidney transplantation. While BKV has been described in non‐kidney transplant recipients, data are limited regarding its epidemiology and outcomes in pancreas transplan…
View article: Impact of Perioperative Prophylaxis With Enterococcus Activity on Risk of Surgical-Site Infection After Pancreas Transplantation
Impact of Perioperative Prophylaxis With Enterococcus Activity on Risk of Surgical-Site Infection After Pancreas Transplantation Open
Background. Surgical-site infection (SSI) is the most common early infectious complication after pancreas transplantation (PT). Although SSI has been shown to worsen outcomes, little data exist to guide optimal choices in perioperative pro…
View article: Guiding Kidney Transplantation Candidates for Effective Weight Loss: A Clinical Cohort Study
Guiding Kidney Transplantation Candidates for Effective Weight Loss: A Clinical Cohort Study Open
Background Obesity is increasingly common in kidney transplant candidates and may limit access to transplantation. Obesity and diabetes are associated with a high risk for post-transplant complications. The best approach to weight loss to …
View article: Epstein Barr Virus–Negative Lymphoplasmacytic Proliferation Limited to the Renal Allograft: A Unique Presentation of a Rare Disease
Epstein Barr Virus–Negative Lymphoplasmacytic Proliferation Limited to the Renal Allograft: A Unique Presentation of a Rare Disease Open
Posttransplant lymphoma, classified as posttransplant lymphoproliferative disorder (PTLD) in the majority of cases, affects 1% to 3% of kidney transplant recipients and is associated with significant morbidity and mortality.1,2 The clinica…
View article: Prospective Longitudinal Study Evaluating Comprehensive Metabolic and Life Style Characteristics of Pancreas Transplantation Recipients
Prospective Longitudinal Study Evaluating Comprehensive Metabolic and Life Style Characteristics of Pancreas Transplantation Recipients Open
Introduction: Pancreas Transplantation (PT) improves quality of life in Type 1 Diabetes (T1D) patients but limited longitudinal data are available regarding comprehensive metabolic assessment and lifestyle. Our objective was to comprehensi…
View article: 681. Induction Immunosuppression Selection in People Living with HIV Undergoing Deceased Donor Kidney Transplantation: U.S. National Trends from 2000 to 2018
681. Induction Immunosuppression Selection in People Living with HIV Undergoing Deceased Donor Kidney Transplantation: U.S. National Trends from 2000 to 2018 Open
Background Human Immunodeficiency Virus (HIV) outcomes have significantly improved at the expense of other age-related diseases including chronic kidney disease. Early reports of people living with HIV (PLWH) undergoing deceased-donor kidn…
View article: Nonrecurrent Early Post-Transplantation Focal Segmental Glomerulosclerosis
Nonrecurrent Early Post-Transplantation Focal Segmental Glomerulosclerosis Open
Focal segmental glomerulosclerosis (FSGS) is one of the most common causes of nephrotic syndrome in adults, and the incidence of this diagnosis is increasing.1Haas M. Meehan S.M. Karrison T.G. et al.Changing etiologies of unexplained adult…
View article: SUN-624 Low Risk of Major Adverse Cardiovascular Events After Pancreas Transplantation Alone
SUN-624 Low Risk of Major Adverse Cardiovascular Events After Pancreas Transplantation Alone Open
INTRODUCTION: Type 1 Diabetes (T1D) patients have an increased risk for major adverse cardiovascular events (MACE). Pancreas Transplantation Alone (PTA) in patients with T1D achieves near normal glucose control for a prolonged period but l…
View article: Volumetric Microsampling of Capillary Blood Spot vs Whole Blood Sampling for Therapeutic Drug Monitoring of Tacrolimus and Cyclosporin A: Accuracy and Patient Satisfaction
Volumetric Microsampling of Capillary Blood Spot vs Whole Blood Sampling for Therapeutic Drug Monitoring of Tacrolimus and Cyclosporin A: Accuracy and Patient Satisfaction Open
Background Immunosuppressant therapeutic drug monitoring (TDM) usually requires outpatient travel to hospitals or phlebotomy sites for venous blood collection; however Mitra® Microsampling Device (MSD) sampling could allow self-collection …
View article: Ten Years of Kidney Paired Donation at Mayo Clinic: The Benefits of Incorporating ABO/HLA Compatible Pairs
Ten Years of Kidney Paired Donation at Mayo Clinic: The Benefits of Incorporating ABO/HLA Compatible Pairs Open
Background. We examined the 10-year experience of Mayo Clinic's kidney paired donation (KPD).We aimed to determine the benefits for the recipients of enrolled ABO/HLA compatible pairs and determine the factors associated with prolonged KPD…
View article: SUN-133 Glycemic Control in T1D Subjects before and after Pancreas Transplantation
SUN-133 Glycemic Control in T1D Subjects before and after Pancreas Transplantation Open
Type 1 diabetes (T1D) is characterized by significant glycemic variability (GV) with current insulin based therapeutic options. Pancreas transplantation (PT) is performed in certain individuals with T1D with and without and end-stage renal…
View article: Use of Eculizumab for Active Antibody-mediated Rejection That Occurs Early Post–kidney Transplantation: A Consecutive Series of 15 Cases
Use of Eculizumab for Active Antibody-mediated Rejection That Occurs Early Post–kidney Transplantation: A Consecutive Series of 15 Cases Open
Background. Active antibody-mediated rejection (AMR) that occurs during the amnestic response within the first month posttransplant is a rare but devastating cause of early allograft loss after kidney transplant. Prior reports of eculizuma…
View article: Modeling graft loss in patients with donor-specific antibody at baseline using the Birmingham-Mayo (BirMay) predictor: Implications for clinical trials
Modeling graft loss in patients with donor-specific antibody at baseline using the Birmingham-Mayo (BirMay) predictor: Implications for clinical trials Open
Predicting which renal allografts will fail and the likely cause of failure is important in clinical trial design to either enrich patient populations to be or as surrogate efficacy endpoints for trials aimed at improving long-term graft s…
View article: NASA-TLX Assessment of Surgeon Workload Variation Across Specialties
NASA-TLX Assessment of Surgeon Workload Variation Across Specialties Open
Objective: With advancements in surgical equipment and procedures, human–system interactions in operating rooms affect surgeon workload and performance. Workload was measured across surgical specialties using surveys to identify potential …
View article: Identifying Barriers to Preemptive Kidney Transplantation in a Living Donor Transplant Cohort
Identifying Barriers to Preemptive Kidney Transplantation in a Living Donor Transplant Cohort Open
Background Despite substantial evidence demonstrating clear benefit, rates of preemptive kidney transplantation (PreKTx) remain low in the United States. Our goal was to identify barriers to PreKTx. Methods Using a telephone-administered q…
View article: Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study
Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study Open
allo-SCT led to a significant reduction in the size of the HIV-1 reservoir and a >9-month-long ART-free remission from HIV-1 replication. Phylogenetic analyses suggest that the origin of rebound virus was distinct from the viruses identifi…
View article: Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease
Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease Open
Aims Short-term studies have reported left ventricular (LV) dilatation following surgical creation of arteriovenous fistulas (AVF) or arteriovenous grafts (AVGs), but chronic cardiac structural and functional changes have not been examined…
View article: Kidney Transplant With Low Levels of DSA or Low Positive B-Flow Crossmatch
Kidney Transplant With Low Levels of DSA or Low Positive B-Flow Crossmatch Open
Kidney transplantation with low-level DSA with or without a low positive XM is a reasonable option for highly sensitized patients and may be advantageous compared with waiting for a negative XM deceased donor. The risk for CAMR is low in p…
View article: Survival Benefit in Older Patients Associated With Earlier Transplant With High KDPI Kidneys
Survival Benefit in Older Patients Associated With Earlier Transplant With High KDPI Kidneys Open
PreKT and non-preKT KDPI greater than 85% transplant was associated with lower mortality hazard after the first year compared with the waitlist including KDPI 0% to 85% transplants in patients older than 60 years. Further consideration sho…
View article: Bad Memory: CD4 T Cell Presensitization Fosters Antibody-Mediated Kidney Transplant Rejection
Bad Memory: CD4 T Cell Presensitization Fosters Antibody-Mediated Kidney Transplant Rejection Open
Kidney transplantation remains the most effective and durable treatment for patients with ESRD. However, whereas graft and patient survival rates have improved over the last 2–3 decades, up to 50% of kidney grafts will be lost by 10 years.…