Patrick G. Johnston
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View article: Supplementary Figure Legends from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Supplementary Figure Legends from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
Figure legends for Supplementary Figures
View article: Supplementary Figure 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Figure 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 32K, QPCR validations.
View article: Supplementary materials and methods from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer
Supplementary materials and methods from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer Open
Supplementary materials and methods
View article: Supplementary Table 7 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 7 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 11K, Results from KEGG pathway analysis for p53 wild-type and p53 null basal comparison. The table shows the number of genes in each pathway and the p value associated with that pathway calculated using hypergeometric statistics…
View article: Data from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Data from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non–small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor FLIP is a critical regulator of cell death that is frequ…
View article: Supplementary Figure 1 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Supplementary Figure 1 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
Response of H460 and A549 cells to IR
View article: Supplementary Table 2 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 2 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 62K, unsupervised top 10 positive and negative correlated genes - clinical.
View article: Supplementary Figure Legends from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Supplementary Figure Legends from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
Figure legends for Supplementary Figures
View article: Supplementary Table 6 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 6 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 64K, unsupervised top 10 positive and negative correlated genes - SN38 inducible.
View article: Data from Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy
Data from Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy Open
A recent phase II study of patients with metastatic colorectal carcinoma showed that mismatch repair gene status was predictive of clinical response to PD-1–targeting immune checkpoint blockade. Further examination revealed strong correlat…
View article: Supplementary Figure 3 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Supplementary Figure 3 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
IR-induced changes in cell surface expression of death receptors
View article: Supplementary Table 6 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 6 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 35K, Real-time PCR validation of HCT116 p53 null cells following treatment with 5nM SN38 for 6, 12 and 24h. This table shows the Pearson's correlation and p values for each individual gene
View article: Data from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Data from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
The topoisomerase I inhibitor irinotecan is used to treat advanced colorectal cancer and has been shown to have p53-independent anticancer activity. The aim of this study was to identify the p53-independent signaling mechanisms activated b…
View article: Supplementary Table 5 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 5 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 63K, unsupervised top 10 positive and negative correlated genes - SN38 basal.
View article: Supplementary Figure 3 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Supplementary Figure 3 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
IR-induced changes in cell surface expression of death receptors
View article: Supplementary Table 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 41K, QPCR validation.
View article: Supplementary Table 4 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 4 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 214K, List showing 2102 genes that are constitutively altered between isogenic HCT116 p53wild-type and HCT116 p53null cells. Genes have been normalised and filtered as stated in the materials and methods
View article: Supplementary Table 3 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 3 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 61K, unsupervised top 10 positive and negative correlated genes - 5-FU basal.
View article: Supplementary Table 6 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Supplementary Table 6 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
PDF file - 64K, unsupervised top 10 positive and negative correlated genes - SN38 inducible.
View article: Data from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer
Data from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer Open
BRAFV600E mutations occur in ∼10% of colorectal cancer cases, are associated with poor survival, and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the …
View article: Supplementary Table 6 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 6 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 35K, Real-time PCR validation of HCT116 p53 null cells following treatment with 5nM SN38 for 6, 12 and 24h. This table shows the Pearson's correlation and p values for each individual gene
View article: Data from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Data from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer Open
Chemotherapy response rates for advanced colorectal cancer remain disappointingly low, primarily because of drug resistance, so there is an urgent need to improve current treatment strategies. To identify novel determinants of resistance t…
View article: Supplementary Table 2 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 2 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 321K, List showing 2544 genes that are uniquely altered following SN38 treatment over time in HCT116 p53wild-type cells only. Genes have been normalised and filtered as stated in the materials and methods
View article: Supplementary Figures S1-S6 from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer
Supplementary Figures S1-S6 from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer Open
Figure S1: Discovery and validation datasets used in the study; Figure S2: Sensitivity of BRAFMT and WT CRC cells to acute ER stress induction; Figure S3: Sensitivity of BRAFMT and WT CRC cells to ACY-1215 and carfilzomib; Figure S4: Effec…
View article: Supplementary Figures 1 through 3 from Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy
Supplementary Figures 1 through 3 from Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy Open
Supplementary figure 1: A +B. Hierarchical clustering of microdissected stromal and epithelial (A) and FACS sorted endothelial, fibroblast, epithelial and leukocyte (B) cell populations using previously published non-epithelial derived gen…
View article: Supplementary Table 7 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 7 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 11K, Results from KEGG pathway analysis for p53 wild-type and p53 null basal comparison. The table shows the number of genes in each pathway and the p value associated with that pathway calculated using hypergeometric statistics…
View article: Supplementary Tables S1-S4 from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer
Supplementary Tables S1-S4 from The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic <i>BRAF</i> Mutant Colorectal Cancer Open
Table S1: Top 20 pathways identified by IPA containing genes significantly upregulated between poor and good prognostic BRAFMT stage II/III CRC in GSE39582; Table S2: Top 20 pathways identified by IPA containing genes significantly downreg…
View article: Supplementary Table 3 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 3 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 261K, List showing 1986 genes that are uniquely altered following SN38 treatment over time in HCT116 p53null cells only. Genes have been normalised and filtered as stated in the materials and methods
View article: Supplementary Table 5 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Supplementary Table 5 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells Open
PDF file - 11K, Real-time PCR validation of genes basally altered between HCT116 p53 null cells and HCT116 p53 wild-type cells. This table shows the p53 null fold change by microarray and the p53 null fold change by real-time PCR, all comp…
View article: Supplementary Figure 2 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
Supplementary Figure 2 from FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer Open
Caspase-8 dependent apoptosis induced by IR