Patrick Giraudeau
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View article: Fast Multidimensional Flow Nuclear Magnetic Resonance at High Field for Real‐Time Reaction Monitoring and Flow Synthesis
Fast Multidimensional Flow Nuclear Magnetic Resonance at High Field for Real‐Time Reaction Monitoring and Flow Synthesis Open
Flow nuclear magnetic resonance (NMR) at high field is a powerful approach for the online monitoring of chemical reactions, which provides real‐time quantitative and structural information. While 1D 1 H spectra are commonly collected for N…
View article: Clean <sup>1</sup>H NMR Spectra of Products Directly from Batch and Flow Reaction Mixtures
Clean <sup>1</sup>H NMR Spectra of Products Directly from Batch and Flow Reaction Mixtures Open
Nuclear magnetic resonance (NMR) spectroscopy is widely used for the monitoring of chemical reactions. Flow NMR methods are being increasingly used to monitor reactions carried out in either batch or flow synthesis mode. Kinetic informatio…
View article: Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization
Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization Open
International audience
View article: Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation
Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation Open
This Perspective seeks to reconnect the current practice of nuclear magnetic resonance (NMR) spectroscopy in chemical structure and quantitative (qNMR) analysis with its roots in classical physics and quantum mechanics (QM). Rationales for…
View article: Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, cross‐over trial
Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, cross‐over trial Open
Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to as…
View article: Evaluation of pure shift NMR methods for the analysis of complex metabolite mixtures with a benchtop NMR spectrometer
Evaluation of pure shift NMR methods for the analysis of complex metabolite mixtures with a benchtop NMR spectrometer Open
A comparison of ultra-resolved pure shift NMR techniques, mitigating the resolution problem of compact NMR instruments, showed that the J-resolved double echo is the most performant technique, enabling the profiling of biological complex m…
View article: Hyperpolarized <sup>13</sup>C NMR Metabolomics of Urine Samples at Natural Abundance Applied to Chronic Kidney Disease
Hyperpolarized <sup>13</sup>C NMR Metabolomics of Urine Samples at Natural Abundance Applied to Chronic Kidney Disease Open
NMR is a central tool in the field of metabolomics, thanks to its ability to provide valuable structural and quantitative information with high precision. Most NMR-based metabolomics studies rely on 1D 1H detection, which is heavily limite…
View article: Pure Shift NMR in Continuous Flow
Pure Shift NMR in Continuous Flow Open
Flow NMR is an expanding analytical approach with applications that include in‐line analysis for process control and optimisation, and real‐time reaction monitoring. The samples monitored by flow NMR are typically mixtures that yield compl…
View article: Issue Information
Issue Information Open
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View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Exploring the complementarity of fast multipulse and multidimensional NMR methods for metabolomics: a chemical ecology case study
Exploring the complementarity of fast multipulse and multidimensional NMR methods for metabolomics: a chemical ecology case study Open
This study investigates the potential and complementarity of high-throughput multipulse and multidimensional NMR methods for metabolomics.
View article: Non‐uniform sampling to enhance the performance of compact NMR for characterizing new psychoactive substances
Non‐uniform sampling to enhance the performance of compact NMR for characterizing new psychoactive substances Open
Efficient and robust analytical methods are needed to improve the identification and subsequent regulation of new psychoactive substances (NPS). NMR spectroscopy is a unique method able to determine the structure of small molecules such as…
View article: Hyperpolarized <sup>1</sup>H and <sup>13</sup>C NMR Spectroscopy in a Single Experiment for Metabolomics
Hyperpolarized <sup>1</sup>H and <sup>13</sup>C NMR Spectroscopy in a Single Experiment for Metabolomics Open
The application of NMR spectroscopy to complex mixture analysis and, in particular, to metabolomics is limited by the low sensitivity of NMR. We recently showed that dissolution dynamic nuclear polarization (d-DNP) could enhance the sensit…
View article: Solution‐State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals
Solution‐State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals Open
The HYPNOESYS method (Hyperpolarized NOE System), which relies on the dissolution of optically polarized crystals, has recently emerged as a promising approach to enhance the sensitivity of NMR spectroscopy in the solution state. However, …
View article: Solution‐State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals
Solution‐State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals Open
The HYPNOESYS method (Hyperpolarized NOE System), which relies on the dissolution of optically polarized crystals, has recently emerged as a promising approach to enhance the sensitivity of NMR spectroscopy in the solution state. However, …
View article: NMR metabolite quantification of a synthetic urine sample: an inter-laboratory comparison of processing workflows
NMR metabolite quantification of a synthetic urine sample: an inter-laboratory comparison of processing workflows Open
Introduction Absolute quantification of individual metabolites in complex biological samples is crucial in targeted metabolomic profiling. Objectives An inter-laboratory test was performed to evaluate the impact of the NMR software, peak-a…
View article: Fast 2D NMR for Metabolomics
Fast 2D NMR for Metabolomics Open
Metabolomics provides crucial information on the metabolism of living organisms, by detecting and quantifying metabolites in biofluids, biopsies or extracts. Metabolomics studies involve analysing large collections of very complex samples …
View article: Fast 2D NMR for Reaction and Process Monitoring
Fast 2D NMR for Reaction and Process Monitoring Open
Real-time monitoring methods are essential to the understanding and control of chemical reactions. NMR spectroscopy is particularly well suited for this purpose. It can provide quantitative information and offers great versatility in the a…
View article: Fast 2D Solution-state NMR
Fast 2D Solution-state NMR Open
Written by active investigators in the field, this book describes state-of-the-art methods that can accelerate the acquisition of 2D NMR spectra in solution-state NMR. The acquisition of fast multi-dimensional NMR data has motivated numero…
View article: Hyperpolarized <sup>13</sup>C NMR Spectroscopy of Urine Samples at Natural Abundance by Quantitative Dissolution Dynamic Nuclear Polarization
Hyperpolarized <sup>13</sup>C NMR Spectroscopy of Urine Samples at Natural Abundance by Quantitative Dissolution Dynamic Nuclear Polarization Open
Hyperpolarized nuclear magnetic resonance (NMR) offers an ensemble of methods that remarkably address the sensitivity issues of conventional NMR. Dissolution Dynamic Nuclear Polarization (d‐DNP) provides a unique and general way to detect …
View article: In‐line Multidimensional NMR Monitoring of Photochemical Flow Reactions
In‐line Multidimensional NMR Monitoring of Photochemical Flow Reactions Open
This work demonstrates the in‐line monitoring of a flow photochemical reaction using 1D and ultrafast 2D NMR methods at high magnetic field. The reaction mixture exiting the flow reactor is flown through the NMR spectrometer and directly a…
View article: The assessment of microalgae biochemistry through NMR non-invasive approach offers new perspectives for their monitoring in photobioreactors
The assessment of microalgae biochemistry through NMR non-invasive approach offers new perspectives for their monitoring in photobioreactors Open
International audience
View article: Quantitative NMR spectroscopy of complex mixtures
Quantitative NMR spectroscopy of complex mixtures Open
The latest developments and applications in highly accurate quantitative NMR of complex mixtures.
View article: Optimization of heteronuclear ultrafast 2D NMR for the study of complex mixtures hyperpolarized by dynamic nuclear polarization
Optimization of heteronuclear ultrafast 2D NMR for the study of complex mixtures hyperpolarized by dynamic nuclear polarization Open
Ultrafast 2D NMR spectroscopy combined with dissolution dynamic nuclear polarization provides rich, sensitive and repeatable NMR fingerprints of complex mixtures.
View article: Broadband ultrafast 2D NMR spectroscopy for online monitoring in continuous flow
Broadband ultrafast 2D NMR spectroscopy for online monitoring in continuous flow Open
2D NMR spectra with full spectra width are obtained from continuously flowing samples in less than 90 s, using interleaved ultrafast NMR acquisition.
View article: Fine optimization of a dissolution dynamic nuclear polarization experimental setting for <sup>13</sup> C NMR of metabolic samples
Fine optimization of a dissolution dynamic nuclear polarization experimental setting for <sup>13</sup> C NMR of metabolic samples Open
NMR-based analysis of metabolite mixtures provides crucial information on biological systems but mostly relies on 1D 1H experiments for maximizing sensitivity. However, strong peak overlap of 1H spectra often is a limitation for the analys…
View article: Preliminary results of a MetaboHUB 2.0 inter-laboratory test on 1D 1H NMR metabolite quantification of a synthetic urine.
Preliminary results of a MetaboHUB 2.0 inter-laboratory test on 1D 1H NMR metabolite quantification of a synthetic urine. Open
Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation
View article: Response to reviewers comments mr-2022-14
Response to reviewers comments mr-2022-14 Open
Abstract. NMR-based analysis of metabolite mixtures provides crucial information on biological systems but mostly relies on 1D 1H experiments for maximizing sensitivity. However, strong peak overlap of 1H spectra often is a limitation for …