M. Patrick Griffith
YOU?
Author Swipe
View article: Artificial intelligence enhances genomic surveillance in healthcare outbreak investigations
Artificial intelligence enhances genomic surveillance in healthcare outbreak investigations Open
Background: Outbreak investigation and control are critical for preventing the spread of infectious diseases in healthcare settings. Traditional methods rely on manual processes, which are time-consuming and limited in scope. Whole genome …
View article: Genomic epidemiology of healthcare-associated respiratory virus infections in Pittsburgh, Pennsylvania, 2018–2020
Genomic epidemiology of healthcare-associated respiratory virus infections in Pittsburgh, Pennsylvania, 2018–2020 Open
Background: Respiratory virus transmission in healthcare settings is not well understood. To investigate the transmission dynamics of common healthcare-associated respiratory virus infections, we performed retrospective whole genome sequen…
View article: Enhanced discrimination of <i>Clostridioides difficile</i> transmission using whole-genome sequencing and <i>in silico</i> multi-locus variable number tandem repeat analysis
Enhanced discrimination of <i>Clostridioides difficile</i> transmission using whole-genome sequencing and <i>in silico</i> multi-locus variable number tandem repeat analysis Open
Whole-genome sequencing (WGS) is used to establish genetic relatedness of bacteria and track outbreaks in healthcare settings. While WGS provides sufficient discriminatory power to make inferences about genetic relatedness and transmission…
View article: Emergence and Epidemiology of Dominant Variants of Human Metapneumovirus in the United States between 2016 and 2021
Emergence and Epidemiology of Dominant Variants of Human Metapneumovirus in the United States between 2016 and 2021 Open
Human metapneumovirus (HMPV) causes acute respiratory disease worldwide and is the second leading cause of lower respiratory infection and hospitalization in young children in the US. There is no licensed vaccine or therapeutic. HMPV mutat…
View article: Enhancing Cabbage Palm Resilience to Saltwater Stress through Silicon Applications
Enhancing Cabbage Palm Resilience to Saltwater Stress through Silicon Applications Open
Saltwater intrusion driven by climate change increasingly imperils Florida’s coastal ecosystems. This study investigated whether silicon amendments can buffer cabbage palm ( Sabal palmetto ) seedlings against saline stress. One-year-old se…
View article: Comparative <i>in vitro</i> activity of sulbactam with avibactam or durlobactam against carbapenem-resistant <i>Acinetobacter baumannii</i>
Comparative <i>in vitro</i> activity of sulbactam with avibactam or durlobactam against carbapenem-resistant <i>Acinetobacter baumannii</i> Open
Objective To determine the in vitro activity of sulbactam in combination with avibactam or durlobactam with and without meropenem or imipenem against carbapenem-resistant Acinetobacter baumannii clinical isolates. Methods Standardized susc…
View article: Genomic Epidemiology of Healthcare-Associated Respiratory Virus Infections
Genomic Epidemiology of Healthcare-Associated Respiratory Virus Infections Open
Background Respiratory virus transmission in healthcare settings is not well understood. To investigate the transmission dynamics of common healthcare-associated respiratory virus infections, we performed retrospective whole genome sequenc…
View article: Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium Open
Gastrointestinal colonization by the nosocomial pathogen vancomycin-resistant Enterococcus faecium (VREfm) can lead to bloodstream infections with high mortality rates. Shifts in VREfm lineages found within healthcare settings occur, but r…
View article: Biological invasion by the cycad‐specific scale pest <i>Aulacaspis yasumatsui</i> ( <scp>Diaspididae</scp> ) into <i>Cycas revoluta</i> ( <scp>Cycadaceae</scp> ) populations on <scp>Amami‐Oshima</scp> and <scp>Okinawa</scp> ‐jima, <scp>Japan</scp>
Biological invasion by the cycad‐specific scale pest <i>Aulacaspis yasumatsui</i> ( <span>Diaspididae</span> ) into <i>Cycas revoluta</i> ( <span>Cycadaceae</span> ) populations on <span>Amami‐Oshima</span> and <span>Okinawa</span> ‐jima, <span>Japan</span> Open
The islands of the Ryukyu archipelago in Japan are biologically diverse, supporting numerous plant and animal taxa found nowhere else. One of the most iconic plants is Cycas revoluta Thunb., the only cycad native to Japan. At this moment, …
View article: Transmission of group A Streptococcus in long-term care: An outbreak investigation
Transmission of group A Streptococcus in long-term care: An outbreak investigation Open
We report 2 outbreaks comprising a cluster of 18 group A Streptococcal infections across 2 nursing facilities. Point prevalence surveillance testing identified 8 of 18 cases, and whole genome sequencing validated transmission pathways. Inf…
View article: Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control
Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control Open
Background Current methods are insufficient alone for outbreak detection in hospitals. Real-time genomic surveillance using offers the potential to detect otherwise unidentified outbreaks. We initiated and evaluated the Enhanced Detection …
View article: Frequency of cefiderocol heteroresistance among patients treated with cefiderocol for carbapenem-resistant <i>Acinetobacter baumannii</i> infections
Frequency of cefiderocol heteroresistance among patients treated with cefiderocol for carbapenem-resistant <i>Acinetobacter baumannii</i> infections Open
Background Cefiderocol exhibits potent in vitro activity against carbapenem-resistant Acinetobacter baumannii (CRAb), but this activity has not consistently translated to improved outcomes among patients. Cefiderocol heteroresistance, or t…
View article: Evolution of extended-spectrum β-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years
Evolution of extended-spectrum β-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years Open
Escherichia coli multi-locus sequence type ST131 is a globally distributed pandemic lineage that causes multidrug-resistant extra-intestinal infections. ST131 E. coli frequently produce extended-spectrum β-lactamases (ESBLs), which confer …
View article: Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant<i>Enterococcus faecium</i>
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant<i>Enterococcus faecium</i> Open
Vancomycin-resistant Enterococcus faecium (VREfm) is a prevalent healthcare-acquired pathogen. Gastrointestinal colonization can lead to difficult-to-treat bloodstream infections with high mortality rates. Prior studies have investigated V…
View article: Enhanced Discrimination of<i>Clostridioides difficile</i>Transmission Using Whole Genome Sequencing and<i>In-Silico</i>Multi-locus Variable Number Tandem Repeat Analysis
Enhanced Discrimination of<i>Clostridioides difficile</i>Transmission Using Whole Genome Sequencing and<i>In-Silico</i>Multi-locus Variable Number Tandem Repeat Analysis Open
Whole genome sequencing (WGS) is used to establish genetic relatedness of bacteria and track outbreaks in healthcare settings. While WGS provides sufficient discriminatory power to make inferences about genetic relatedness and transmission…
View article: Real-time Whole Genome Sequencing Surveillance as an Effective Outbreak Detection and Mitigation Tool
Real-time Whole Genome Sequencing Surveillance as an Effective Outbreak Detection and Mitigation Tool Open
Background: Detection of outbreaks traditionally relies on passive surveillance, and often misidentify or miss outbreaks. Whole genome sequencing (WGS) surveillance has emerged as a proactive measure, enabling early detection of outbreaks …
View article: Population genetics of <i>Zamia decumbens</i> (Zamiaceae, Cycadales), an endangered cycad from the Maya Mountains of Belize
Population genetics of <i>Zamia decumbens</i> (Zamiaceae, Cycadales), an endangered cycad from the Maya Mountains of Belize Open
We utilized 10 microsatellite loci to examine the genetic diversity, genetic structure, and demographic history of Zamia decumbens Calonje, Meerman, M.P. Griff. & Hoese, an endangered cycad species occurring in small populations on karst t…
View article: Genomic sequencing surveillance of patients colonized with vancomycin-resistant<i>Enterococcus</i>(VRE) improves detection of hospital-associated transmission
Genomic sequencing surveillance of patients colonized with vancomycin-resistant<i>Enterococcus</i>(VRE) improves detection of hospital-associated transmission Open
Background Vancomycin-resistant enterococcal (VRE) infections pose significant challenges in healthcare. Transmission dynamics of VRE are complex, often involving patient colonization and subsequent transmission through various healthcare-…
View article: Genomic patterns of native palms from the Leeward Antilles confirm single-island endemism and guide conservation priorities
Genomic patterns of native palms from the Leeward Antilles confirm single-island endemism and guide conservation priorities Open
Systematic study of the palm (Arecaceae) flora from the Leeward Antilles marked both Sabal antillensis and Sabal lougheediana as endemic to Curaçao and Bonaire respectively. Although both species are emergent, obvious and charismatic eleme…
View article: Harnessing the Diversity of Burkholderia spp. Prophages for Therapeutic Potential
Harnessing the Diversity of Burkholderia spp. Prophages for Therapeutic Potential Open
Burkholderia spp. are often resistant to antibiotics, and infections with these organisms are difficult to treat. A potential alternative treatment for Burkholderia spp. infections is bacteriophage (phage) therapy; however, it can be diffi…
View article: Real-time genomic epidemiologic investigation of a multispecies plasmid-associated hospital outbreak of NDM-5-producing Enterobacterales infections
Real-time genomic epidemiologic investigation of a multispecies plasmid-associated hospital outbreak of NDM-5-producing Enterobacterales infections Open
Our investigation revealed a complex, multispecies outbreak of NDM involving multiple plasmid transfer and bacterial transmission events. We highlight the utility of combining traditional IP&C and prospective genomic methods in identifying…
View article: ICE volume 45 issue 2 Cover and Front matter
ICE volume 45 issue 2 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: In Vivo Evolution of a <i>Klebsiella pneumoniae</i> Capsule Defect With <i>wcaJ</i> Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection
In Vivo Evolution of a <i>Klebsiella pneumoniae</i> Capsule Defect With <i>wcaJ</i> Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection Open
Background Klebsiella pneumoniae carbapenemase–producing K pneumoniae (KPC-Kp) bloodstream infections are associated with high mortality. We studied clinical bloodstream KPC-Kp isolates to investigate mechanisms of resistance to complement…
View article: Harnessing the diversity of<i>Burkholderia</i>spp. prophages for therapeutic potential
Harnessing the diversity of<i>Burkholderia</i>spp. prophages for therapeutic potential Open
Burkholderia spp. are often resistant to antibiotics, and infections with these organisms are difficult to treat. A potential alternative treatment for Burkholderia spp. infections is bacteriophage (phage) therapy; however, it can be diffi…
View article: Prolonged bacterial carriage and hospital transmission detected by whole genome sequencing surveillance
Prolonged bacterial carriage and hospital transmission detected by whole genome sequencing surveillance Open
An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the 'Save PDF' action button.
View article: Impact of discontinuation of contact precautions on surveillance- and whole genome sequencing-defined methicillin-resistant <i>Staphylococcus aureus</i> healthcare-associated infections
Impact of discontinuation of contact precautions on surveillance- and whole genome sequencing-defined methicillin-resistant <i>Staphylococcus aureus</i> healthcare-associated infections Open
Objective: Prior studies evaluating the impact of discontinuation of contact precautions (DcCP) on methicillin-resistant Staphylococcus aureus (MRSA) outcomes have characterized all healthcare-associated infections (HAIs) rather than those…
View article: The utility of whole-genome sequencing to inform epidemiologic investigations of SARS-CoV-2 clusters in acute-care hospitals
The utility of whole-genome sequencing to inform epidemiologic investigations of SARS-CoV-2 clusters in acute-care hospitals Open
Objective: To evaluate the utility of selective reactive whole-genome sequencing (WGS) in aiding healthcare-associated cluster investigations. Design: Mixed-methods quality-improvement study. Setting: Thes study was conducted across 8 acut…