Patrick Haider
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View article: Cell-Free Circulating Mitochondrial DNA Levels Following High-Frequency Jet Ventilation—A Post Hoc Analysis
Cell-Free Circulating Mitochondrial DNA Levels Following High-Frequency Jet Ventilation—A Post Hoc Analysis Open
Background: Mitochondrial DNA (mtDNA), normally enclosed within mitochondria, can be released into circulation in response to cellular stress, hypoxia, or inflammation. Its detection in plasma has been proposed as a marker of cellular inju…
View article: Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis
Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis Open
Macrophage-to-foam cell transition is an integral part of atherosclerotic plaque progression. Particularly, oxidized low-density lipoprotein (oxLDL) is a driving factor in foam cell formation, altering macrophage function and metabolism. T…
View article: Effects of the 2019 guideline update on lipid-lowering therapy in patients with acute coronary syndromes
Effects of the 2019 guideline update on lipid-lowering therapy in patients with acute coronary syndromes Open
Background The European Society of Cardiology regularly updates its clinical practice guidelines. However, it is not well established whether guideline changes have significant effects on actual clinical practice. Therefore, we retrospecti…
View article: Determinants of time to first palliative care consultation in hospitalized patients with advanced or terminal illness – A retrospective analysis
Determinants of time to first palliative care consultation in hospitalized patients with advanced or terminal illness – A retrospective analysis Open
This study highlights earlier PC consultation requests during hospitalization for individuals with malignant diseases and for women. The low rate of follow-up PC consultations indicates that the importance of regular PC involvement to impr…
View article: Markers of Hemophagocytic Lymphohistiocytosis Are Associated with Mortality in Critically Ill Patients
Markers of Hemophagocytic Lymphohistiocytosis Are Associated with Mortality in Critically Ill Patients Open
Background: Critically ill patients often display systemic immune dysregulation and increased inflammatory activity. Hemophagocytic lymphohistiocytosis (HLH) represents a rare syndrome defined by the inappropriate survival of cytotoxic T c…
View article: Lipoprotein(a) levels in patients with cryptogenic stroke and persistent foramen ovale
Lipoprotein(a) levels in patients with cryptogenic stroke and persistent foramen ovale Open
Background Elevated levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of atherosclerotic cardiovascular disease (ASCVD). However, it is not known whether high Lp(a) is associated with cryptogenic stroke. M…
View article: Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice
Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice Open
BACKGROUND: Venous thromboembolism is a major health problem. After thrombus formation, its resolution is essential to re-establish blood flow, which is crucially mediated by infiltrating neutrophils and monocytes in concert with activated…
View article: Inclisiran reduces expression of Toll-like receptor-4 on circulating monocytes
Inclisiran reduces expression of Toll-like receptor-4 on circulating monocytes Open
Background Toll-like receptor 4 (TLR4) is a key regulator of both innate and adaptive immune responses and its functions affects the initiation and progression of atherosclerosis. In addition, it has recently been shown that TLR4 regulates…
View article: Effects of the 2019 guideline-update on lipid therapy in patients with acute coronary syndromes
Effects of the 2019 guideline-update on lipid therapy in patients with acute coronary syndromes Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): 2 Ludwig Boltzmann Institute for Cardiovascular Research. Background The European Society of Cardiology regularly updates its clinical practic…
View article: Lipid-lowering therapy and LDL-cholesterol in patients after acute coronary syndromes
Lipid-lowering therapy and LDL-cholesterol in patients after acute coronary syndromes Open
Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Medical University of Vienna. Background Intensive lipid lowering after acute coronary syndromes (ACS) reduces recurrent cardiovascular events, h…
View article: Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction
Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction Open
Aims Ischaemia–reperfusion injury (IRI) following myocardial infarction remains a challenging topic in acute cardiac care and consecutively arising heart failure represents a severe long‐term consequence. The extent of neutrophil infiltrat…
View article: Association of telomere length and mitochondrial DNA copy number, two biomarkers of biological aging, with the risk of venous thromboembolism
Association of telomere length and mitochondrial DNA copy number, two biomarkers of biological aging, with the risk of venous thromboembolism Open
Lower mtDNA levels were found in patients with VTE compared to controls, indicating an association of biological aging with risk of VTE.
View article: Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions Open
Atherosclerosis is a chronic, inflammatory disease of the vessel wall where triggered immune cells bind to inflamed endothelium, extravasate and sustain local inflammation. Leukocyte adhesion and extravasation are mediated by adhesion mole…
View article: Interleukin‐4 receptor alpha signaling regulates monocyte homeostasis
Interleukin‐4 receptor alpha signaling regulates monocyte homeostasis Open
Interleukin‐4 (IL‐4) and its receptors (IL‐4R) promote the proliferation and polarization of macrophages. However, it is unknown if IL‐4R also influences monocyte homeostasis and if steady state IL‐4 levels are sufficient to affect monocyt…
View article: Quantitative and Functional Assessment of the Influence of Routinely Used Cryopreservation Media on Mononuclear Leukocytes for Medical Research
Quantitative and Functional Assessment of the Influence of Routinely Used Cryopreservation Media on Mononuclear Leukocytes for Medical Research Open
Quantitative and functional analysis of mononuclear leukocyte populations is an invaluable tool to understand the role of the immune system in the pathogenesis of a disease. Cryopreservation of mononuclear cells (MNCs) is routinely used to…
View article: Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection
Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection Open
Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes resp…
View article: MiRNA Let-7a and Let-7d Are Induced by Globotriaosylceramide via NF-kB Activation in Fabry Disease
MiRNA Let-7a and Let-7d Are Induced by Globotriaosylceramide via NF-kB Activation in Fabry Disease Open
Background: Fabry disease is a hereditary genetic defect resulting in reduced activity of the enzyme α-galactosidase-A and the accumulation of globotriaosylceramide (Gb3) in body fluids and cells. Gb3 accumulation was especially reported f…
View article: Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation
Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation Open
Overall, we therefore suggest that the main mechanism of reducing inflammation of trimetazidine and FAO inhibition is the reduction of the NLRP-3 activation leading to reduced levels of the proinflammatory cytokine IL-1β.
View article: Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression
Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression Open
Nicorandil, a balanced vasodilator, is used in the second-line therapy of angina pectoris. In this study, we aimed to illuminate the effects of nicorandil on inflammation, apoptosis, and atherosclerotic plaque progression. Twenty-five LDL-…
View article: PI3-kinase inhibition as a strategy to suppress the leukemic stem cell niche in Ph+ chronic myeloid leukemia.
PI3-kinase inhibition as a strategy to suppress the leukemic stem cell niche in Ph+ chronic myeloid leukemia. Open
Recent data suggest that the disease-associated microenvironment, known as the leukemic stem cell (LSC) niche, is substantially involved in drug resistance of LSC in BCR-ABL1+ chronic myeloid leukemia (CML). Attacking the LSC niche in CML …
View article: Supplementary Material for: Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection
Supplementary Material for: Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection Open
Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes resp…
View article: Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets
Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets Open
Objective: Macrophages are immune cells, capable to remodel the extracellular matrix, which can harbor extracellular DNA incorporated into neutrophil extracellular traps (NETs). To study the breakdown of NETs we studied the capability of m…
View article: Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles
Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles Open
Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative pol…
View article: Protease-Activated Receptors 1 and 3 are Differentially Expressed on Human Monocyte Subsets and are Upregulated by Lipopolysaccharide Ex Vivo and In Vivo
Protease-Activated Receptors 1 and 3 are Differentially Expressed on Human Monocyte Subsets and are Upregulated by Lipopolysaccharide Ex Vivo and In Vivo Open
Monocytes are activated in inflammatory conditions via a variety of cytokine receptors as well as in a procoagulatory setting through thrombin, acting upon protease-activated receptors (PARs). This study investigated the expression pattern…