Patrick Hamel
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View article: Management of vernal keratoconjunctivitis: Navigating a changing treatment landscape
Management of vernal keratoconjunctivitis: Navigating a changing treatment landscape Open
Vernal keratoconjunctivitis (VKC) is a chronic, progressive, and potentially sight-threatening form of ocular inflammatory disease that primarily affects children and young adults. Prevalence varies by region, ranging from <2 per 10,000 in…
View article: Complications Occurring Through 5 Years Following Primary Intraocular Lens Implantation for Pediatric Cataract
Complications Occurring Through 5 Years Following Primary Intraocular Lens Implantation for Pediatric Cataract Open
Importance Lensectomy with primary intraocular lens (IOL) implantation is often used in the management of nontraumatic pediatric cataract, but long-term data evaluating the association of age and IOL location with the incidence of complica…
View article: Incidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy
Incidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy Open
Importance Glaucoma can develop following cataract removal in children. Objective To assess the cumulative incidence of glaucoma-related adverse events (defined as glaucoma or glaucoma suspect) and factors associated with risk of these adv…
View article: An Infant with Bilateral Keratitis: From Infectious to Genetic Diagnosis
An Infant with Bilateral Keratitis: From Infectious to Genetic Diagnosis Open
BACKGROUND Tyrosinemia Type II (TYRII) is a rare autosomal recessive inborn error of metabolism caused by deficiency of tyrosine aminotransferase (TAT), leading to hypertyrosinemia. TYRII patients often present in the first year of life wi…
View article: Reduced Contrast Sensitivity in Young Adults Who Had Retinopathy of Prematurity
Reduced Contrast Sensitivity in Young Adults Who Had Retinopathy of Prematurity Open
Retinopathy of prematurity (ROP) may have long-term consequences. We studied the visual function of young adults born prematurely; ROP was associated with a lower visual acuity and a reduced contrast sensitivity.
View article: Visual Acuity and Ophthalmic Outcomes 5 Years After Cataract Surgery Among Children Younger Than 13 Years
Visual Acuity and Ophthalmic Outcomes 5 Years After Cataract Surgery Among Children Younger Than 13 Years Open
In this cohort study, development of glaucoma or glaucoma suspect was common in children 5 years after lensectomy. Myopic shift was modest during the 5 years after placement of an intraocular lens, which should be factored into implant pow…
View article: Disseminated juvenile xanthogranulomas with ocular involvement: A case report and literature review
Disseminated juvenile xanthogranulomas with ocular involvement: A case report and literature review Open
Cutaneous juvenile xanthogranuloma is an uncommon disorder usually arising during infancy. Systemic involvement of juvenile xanthogranuloma remains rare, and there are no published guidelines to date on screening extracutaneous manifestati…
View article: 21 Long-Term Ophthalmologic Outcome of Young Adults Born Extremely Preterm
21 Long-Term Ophthalmologic Outcome of Young Adults Born Extremely Preterm Open
Primary Subject area Ophthalmology Background Retinopathy of prematurity (ROP) remains the dominant cause of severe visual impairment in childhood in North America and Europe. With the salient improvement in neonatal care since the 1980s, …
View article: Visual Outcomes and Complications After Lensectomy for Traumatic Cataract in Children
Visual Outcomes and Complications After Lensectomy for Traumatic Cataract in Children Open
Trauma was not a common cause of pediatric cataract requiring surgery. For children with traumatic cataract, substantial ocular morbidity including permanent vision loss was found, and long-term eye and vision monitoring are needed for gla…
View article: Increased Incidence but Lack of Association Between Cardiovascular Risk Factors in Adults Born Preterm
Increased Incidence but Lack of Association Between Cardiovascular Risk Factors in Adults Born Preterm Open
Preterm birth incurs an increased risk of early cardiovascular events and death. In the general population, cardiovascular risk factors cluster in the context of inflammation and oxidative stress. Whether this also occurs in young adults b…
View article: Refining evidence-based retinopathy of prematurity screening guidelines: The SCREENROP study
Refining evidence-based retinopathy of prematurity screening guidelines: The SCREENROP study Open
Purpose Retinopathy of prematurity (ROP) is a potentially blinding condition affecting premature infants for which less than 10% of babies undergoing screening require treatment. This study assessed and validated predictors of developing c…
View article: Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma
Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma Open
Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are sho…
View article: Embryonal Tumor with Multilayered Rosettes Presenting with Intermittent Third Nerve Palsy
Embryonal Tumor with Multilayered Rosettes Presenting with Intermittent Third Nerve Palsy Open
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View article: AB046. The retinoblastoma model for translational research
AB046. The retinoblastoma model for translational research Open
Background: Our national collaborative research initiative is proposing to develop a common infrastructure for Rb research. We are proposing a novel in vivo Rb model using human Rb cells line. Methods: The rabbit model has advantages over …