Patrick Hilden
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View article: The weekend effect on mechanical thrombectomy
The weekend effect on mechanical thrombectomy Open
OBJECTIVES: As hospitals rapidly implement mechanical thrombectomy (MT) into stroke protocols following the pivotal trials in 2015, access to and outcomes from MT may be poorer for weekend-admitted patients. We sought to investigate whethe…
View article: The role of high-risk features in stage II colon cancer after surgical treatment
The role of high-risk features in stage II colon cancer after surgical treatment Open
A proportion of patients with stage II colon cancer treated surgically will have either local or distal recurrence; this group is not well identified. High-risk features (HRF) have been proposed to aid in the determination of which patient…
View article: Real‐world evaluation of the impact of two anti‐SARS‐CoV‐2 monoclonal antibody regimens on COVID‐19 hospitalizations in older adults
Real‐world evaluation of the impact of two anti‐SARS‐CoV‐2 monoclonal antibody regimens on COVID‐19 hospitalizations in older adults Open
Evidence from clinical trials suggest anti‐SARS‐CoV‐2 monoclonal antibodies (mABs) may reduce coronavirus disease 2019 (COVID‐19)‐related hospitalizations. The purpose of this study was to assess the real‐world impact of mAB administration…
View article: Effectiveness of Clinical Decision Tools in Predicting Pulmonary Embolism
Effectiveness of Clinical Decision Tools in Predicting Pulmonary Embolism Open
Objective. The Wells criteria and revised Geneva score are two commonly used clinical decision tools (CDTs) developed to assist physicians in determining when computed tomographic angiograms (CTAs) should be performed to evaluate the high …
View article: Decrease in Hospital Admissions for Acute Surgical Conditions During the COVID-19 Pandemic
Decrease in Hospital Admissions for Acute Surgical Conditions During the COVID-19 Pandemic Open
Mini-Abstract: The nature of emergency room admissions for acute surgical conditions changed during the COVID-19 pandemic with less admissions for potentially life threatening conditions.
View article: Big data, machine learning, and artificial intelligence: a field guide for neurosurgeons
Big data, machine learning, and artificial intelligence: a field guide for neurosurgeons Open
Big data has transformed into a trend phrase in healthcare and neurosurgery, becoming a pervasive and inescapable phrase in everyday life. The upsurge in big data applications is a direct consequence of the drastic boom in information tech…
View article: 554. Early Clinical Outcomes with Tocilizumab for Covid-19: A Two-Center Retrospective Study
554. Early Clinical Outcomes with Tocilizumab for Covid-19: A Two-Center Retrospective Study Open
Background Severe Covid-19 is associated with elevated inflammatory markers, consistent with cytokine release syndrome (CRS). Tocilizumab is an IL-6 inhibitor, effective in treating CRS secondary to CAR-T cell therapy. The efficacy of toci…
View article: Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation
Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation Open
Purpose: Mathematical models combined with new imaging technologies could improve clinical oncology studies. To improve detection of therapeutic effect in patients with cancer, we assessed volumetric measurement of target lesions to estima…
View article: Combining the disease risk index and hematopoietic cell transplant co‐morbidity index provides a comprehensive prognostic model for CD34 <sup>+</sup> ‐selected allogeneic transplantation
Combining the disease risk index and hematopoietic cell transplant co‐morbidity index provides a comprehensive prognostic model for CD34 <sup>+</sup> ‐selected allogeneic transplantation Open
The data that support the findings of this study are available on request from the corresponding author, C Cho. In order to protect the privacy of research participants, the data are not publicly available.
View article: Improved Outcomes With an Enhanced Recovery Approach to Cesarean Delivery
Improved Outcomes With an Enhanced Recovery Approach to Cesarean Delivery Open
OBJECTIVE: To examine the results of a quality-improvement study that implemented an enhanced recovery after surgery (ERAS) program for cesarean delivery. METHODS: A pre–post design was used to assess changes in opioid use, length of stay,…
View article: Phase II Study of a Non-Platinum–Containing Doublet of Paclitaxel and Pemetrexed with Bevacizumab as Initial Therapy for Patients with Advanced Lung Adenocarcinomas
Phase II Study of a Non-Platinum–Containing Doublet of Paclitaxel and Pemetrexed with Bevacizumab as Initial Therapy for Patients with Advanced Lung Adenocarcinomas Open
Many patients with lung cancers cannot receive platinum-containing regimens due to co-morbid medical conditions. We designed the PPB regimen of paclitaxel, pemetrexed, and bevacizumab to maintain or improve outcomes while averting the uniq…
View article: Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin
Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin Open
Quality of immune reconstitution after cord blood transplantation (CBT) without antithymocyte globulin (ATG) in adults is not established. We analyzed immune recovery in 106 engrafted adult CBT recipients (median age 50 years [range 22-70]…
View article: Predicting radiation dosimetric distribution in different regions of the jaw in patients receiving radiotherapy for squamous cell carcinoma of the tonsil
Predicting radiation dosimetric distribution in different regions of the jaw in patients receiving radiotherapy for squamous cell carcinoma of the tonsil Open
Background Radiotherapy (RT), the main treatment for patients with head and neck cancer, can lead to dental complications. Methods We identified 244 patients with squamous cell carcinoma of the tonsil treated with RT from 2004 to 2013. For…
View article: Radiation Dose and Volume to the Pancreas and Subsequent Risk of Diabetes Mellitus: A Report from the Childhood Cancer Survivor Study
Radiation Dose and Volume to the Pancreas and Subsequent Risk of Diabetes Mellitus: A Report from the Childhood Cancer Survivor Study Open
Background Childhood cancer survivors exposed to abdominal radiation (abdRT) are at increased risk for diabetes mellitus, but the association between risk and radiation dose and volume is unclear. Methods Participants included 20 762 5-yea…
View article: Standard Antithymocyte Globulin Dosing Results in Poorer Outcomes in Overexposed Patients after Ex Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation
Standard Antithymocyte Globulin Dosing Results in Poorer Outcomes in Overexposed Patients after Ex Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation Open
Antithymocyte globulin (ATG) use mitigates the risk of graft rejection and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT), but ATG overexposure in the setting of lymphopenia negatively affec…
View article: Busulfan/Melphalan/Fludarabine (Bu/Mel/Flu) Conditioning Versus Total Body Irradiation/Thiotepa/Cyclophosphamide (HFTBI/Thio/Cy) Based Conditioning in Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Undergoing CD34-Selected T-Cell Depleted Allogeneic Stem Cell Transplantation (alloSCT)
Busulfan/Melphalan/Fludarabine (Bu/Mel/Flu) Conditioning Versus Total Body Irradiation/Thiotepa/Cyclophosphamide (HFTBI/Thio/Cy) Based Conditioning in Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Undergoing CD34-Selected T-Cell Depleted Allogeneic Stem Cell Transplantation (alloSCT) Open
IntroductionIn patients with poor risk AML or MDS in first complete remission (CR1), alloSCT can be potentially curative. Comparison of the non-hematologic toxicities between total body irradiation (TBI)-based conditioning versus chemother…
View article: The Easix Score Is Associate with Overall Survival and Non-Relapse Mortality after Ex-Vivo CD34+-Selected Allogeneic HCT.
The Easix Score Is Associate with Overall Survival and Non-Relapse Mortality after Ex-Vivo CD34+-Selected Allogeneic HCT. Open
BackgroundThe EASIX (Endothelial Activation and Stress Index) score has been shown to be associated with NRM and overall survival (OS) after reduced intensity alloHCT. We aimed to validate EASIX in patients who underwent a calcineurin-inhi…
View article: Cytomegalovirus Reactivation Promotes CD8+ T Cell Subset Recovery after Unmodified Allogeneic Hematopoietic Cell Transplantation
Cytomegalovirus Reactivation Promotes CD8+ T Cell Subset Recovery after Unmodified Allogeneic Hematopoietic Cell Transplantation Open
IntroductionT cell reconstitution after alloHCT can be impaired and is associated with relapse as well as infections, especially viral reactivation. Our study is aimed at characterizing patterns of T cell subset recovery in patients underg…
View article: Burden and impact of multifactorial geriatric syndromes in allogeneic hematopoietic cell transplantation for older adults
Burden and impact of multifactorial geriatric syndromes in allogeneic hematopoietic cell transplantation for older adults Open
Multifactorial geriatric syndromes are highly prevalent in older patients with cancer. Because an increasing number of older patients undergo allogeneic hematopoietic stem cell transplantation (allo-HCT), we examined the incidence and impa…