Bhy Chung
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View article: Vinculin influences essential processes in enteric nervous system development and Hirschsprung disease pathogenesis
Vinculin influences essential processes in enteric nervous system development and Hirschsprung disease pathogenesis Open
Vinculin (VCL), a linker between cells and their environment, has rarely been linked to disease. This study examines the role of VCL in the development of the enteric nervous system (ENS) and its relationship to Hirschsprung disease (HSCR)…
View article: Loss of function of Adducin 3 (ADD3) causes abnormal development and impaired barrier function of human and mouse bile duct cells resulting in increased incidence and severity of Biliary Atresia
Loss of function of Adducin 3 (ADD3) causes abnormal development and impaired barrier function of human and mouse bile duct cells resulting in increased incidence and severity of Biliary Atresia Open
Theme-based Research Scheme 2021 (T12-712/21-R); Health and Medical Research Fund (06172096; 03143476); RGC CERG Grant 2019/20 (17105119) to VCHL; Commissioned HMRF (PR-HKU-1) to PKHT.
View article: (315) Different Antibiotic Combinations and Concentrations Have Variable Efficacy Against Common Penile Prosthesis Infection Organisms
(315) Different Antibiotic Combinations and Concentrations Have Variable Efficacy Against Common Penile Prosthesis Infection Organisms Open
Introduction Vancomycin, combined with gentamicin (VG) or piperacillin-tazobactam (V-PTZ), have been shown to confer adequate coverage of the pathogens commonly implicated in clinical penile prosthesis (PP) infection. Objective To date, th…
View article: (027) Anionic Surfactant Solutions Are Incompatible with Both Hydrophilic and Antibiotic Impregnated Penile Prosthesis Surfaces
(027) Anionic Surfactant Solutions Are Incompatible with Both Hydrophilic and Antibiotic Impregnated Penile Prosthesis Surfaces Open
Introduction Anionic surfactants, such as sodium lauryl sulfate (SLS), are currently being used in penile prosthesis (PP) surgery. Objective We hypothesize that use of SLS as a dip and/or irrigation is compatible with both hydrophilic and …
View article: Systematic Review on Questionnaires Reporting Bowel Function and Health-Related Quality of Life in Patients With Hirschsprung Disease
Systematic Review on Questionnaires Reporting Bowel Function and Health-Related Quality of Life in Patients With Hirschsprung Disease Open
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View article: Novel use of a light-emitting nasogastric tube to enhance oesophageal dissection during laparoscopic fundoplication in children: a case report
Novel use of a light-emitting nasogastric tube to enhance oesophageal dissection during laparoscopic fundoplication in children: a case report Open
Light-emitting nasogastric tube is safe and potentially facilitates oesophageal dissection during laparoscopic fundoplication in children.
View article: BMP2 Pan-Cancer Analysis in Multiple Tumor Types of TCGA Datasets *
BMP2 Pan-Cancer Analysis in Multiple Tumor Types of TCGA Datasets * Open
This BMP2 is an indispensable gene in bone development and repair across vertebrates. The relation between BMP2 expression level and tumor genesis/progression has been reported previously. In this study, we use The Cancer Genome Atlas data…
View article: Animal and organoid models to elucidate the anti-fibrotic effect of steroid on biliary atresia
Animal and organoid models to elucidate the anti-fibrotic effect of steroid on biliary atresia Open
Purpose We performed animal and organoid study to evaluate the anti-fibrotic effect of steroid on BA and the underlying patho-mechanism. Methods BA animal models were created by inoculation of mice on post-natal day 1 with Rhesus Rotavirus…
View article: Cholestasis after Kasai operation predicts portal hypertension in native liver survivors of biliary atresia – A multicentre study
Cholestasis after Kasai operation predicts portal hypertension in native liver survivors of biliary atresia – A multicentre study Open
Purpose This study evaluated portal hypertension (PHT) and its predictors among native liver survivors (NLS) of biliary atresia (BA) after Kasai portoenterostomy (KPE). Methods This was a multicenter study using prospectively collected dat…
View article: Animal and organoid models to elucidate the anti-fibrotic effect of steroid on biliary atresia
Animal and organoid models to elucidate the anti-fibrotic effect of steroid on biliary atresia Open
Purpose We performed animal and organoid study to evaluate the anti-fibrotic effect of steroid on biliary atresia (BA) and the underlying patho-mechanism. Methods BA animal models were created by inoculation of mice on post-natal day 1 wit…
View article: A narrative review of genes associated with liver fibrosis in biliary atresia
A narrative review of genes associated with liver fibrosis in biliary atresia Open
Current scientific evidence using gene database has revealed a close association between genetic anomalies and the pathogenesis of liver fibrosis in BA. With a better understanding of these anomalies, therapy targeting these related genes …
View article: Cholestasis after Kasai operation predicts portal hypertension in native liver survivors of biliary atresia: a multicenter study
Cholestasis after Kasai operation predicts portal hypertension in native liver survivors of biliary atresia: a multicenter study Open
Purpose This study evaluated portal hypertension (PHT) and its predictors among native liver survivors (NLS) of biliary atresia (BA) after Kasai portoenterostomy (KPE). Methods This was a multicenter study using prospectively collected dat…
View article: Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids
Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids Open
Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns. Biliatresone, a plant toxin, causes BA-like syndrome in some animals, but its relevance in humans is unknown. To validate the hypothesis…
View article: Prophylactic anti‐reflux procedure for children undergoing laparoscopic gastrostomy: Rethinking of the routine practice
Prophylactic anti‐reflux procedure for children undergoing laparoscopic gastrostomy: Rethinking of the routine practice Open
Aim Laparoscopic gastrostomy is a frequently performed procedure in children requiring long‐term enteral nutrition. The role of prophylactic anti‐reflux surgery during gastrostomy placements is controversial. The current study aims to eval…
View article: Enhancing Neonatal Thoracoscopic Surgical Training with Rabbit Model
Enhancing Neonatal Thoracoscopic Surgical Training with Rabbit Model Open
Background Thoracoscopy, which has an increasing role in the treatment of indexed neonatal surgical conditions, requires adequate training. To support this, the current study aimed to evaluate the feasibility and effectiveness of using liv…
View article: The impact of pre-operative cholecystostomy on laparoscopic excision of choledochal cyst in paediatric patients
The impact of pre-operative cholecystostomy on laparoscopic excision of choledochal cyst in paediatric patients Open
Purpose This aim of this study was to identify the pre-operative risk factors for conversion during laparoscopic excision of choledochal cyst in paediatric patients. Methods A retrospective single-centre study was carried out. All paediatr…
View article: (443) A Randomized Prospective Evaluation of Next-generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Prostheses: Impact of Microbial Identification on Outcomes
(443) A Randomized Prospective Evaluation of Next-generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Prostheses: Impact of Microbial Identification on Outcomes Open
Introduction Traditional culture is the current standard-of-care to determine therapeutic antibiotics for patients suffering from penile prostheses (PP) infections. However, approximately 50% of PPs removed for infection are culture negati…
View article: Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids
Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids Open
Background Choledochal cysts (CC) are congenital bile duct anomalies with 6–30% risk for developing bile duct cancer. However, the molecular mechanisms underlying cancer risk of CC are unknown. We sought to identify the gene expression cha…
View article: Enhanced recovery after surgery in paediatric patients undergoing gastrointestinal surgeries – A scoping review,
Enhanced recovery after surgery in paediatric patients undergoing gastrointestinal surgeries – A scoping review, Open
Objective: Implementing Enhanced Recovery After Surgery (ERAS) protocols has been shown to improve perioperative outcomes in adults undergoing gastrointestinal surgeries. Herewith, we performed a scoping review to evaluate the practice of …
View article: ICG fluorescence angiography is useful in guiding intra-operative surgical decision making in necrotizing enterocolitis
ICG fluorescence angiography is useful in guiding intra-operative surgical decision making in necrotizing enterocolitis Open
Background: Necrotizing enterocolitis (NEC) is a devastating condition in premature babies and surgical resection of the necrotic bowels is often required. Herewith, we reported the application of Indocyanine green fluorescence angiography…
View article: Environmental toxin biliatresone can induce biliary atresia: evidence from human liver organoids
Environmental toxin biliatresone can induce biliary atresia: evidence from human liver organoids Open
Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns. Biliatresone, a plant toxin, caused BA-like syndrome in some animals but its relevance in humans is unknown. To validate the hypothesis …
View article: The outcome of Kasai portoenterostomy after day 70 of life
The outcome of Kasai portoenterostomy after day 70 of life Open
Background The age at Kasai portoenterostomy (KPE) was reported to correlate with the prognosis of patients with biliary atresia (BA) and that a late KPE is bounded to be failure. Herewith, we reported the outcome of patients receiving KPE…
View article: Plasma amyloid-beta levels correlated with impaired hepatic functions: An adjuvant biomarker for the diagnosis of biliary atresia
Plasma amyloid-beta levels correlated with impaired hepatic functions: An adjuvant biomarker for the diagnosis of biliary atresia Open
Background Biliary atresia (BA) is an infantile fibro-obstructive cholestatic disease with poor prognosis. An early diagnosis and timely Kasai portoenterostomy (KPE) improve clinical outcomes. Aggregation of amyloid-beta (Aβ) around hepati…