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View article: Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation
Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation Open
M-TEER effectively reduces MR to ≤1+ and improves symptoms in both aSMR and vSMR. Particularly in aSMR, ≥moderate baseline TR is linked to worse outcomes, warranting consideration as an additional treatment target.
View article: Dynamic mitral regurgitation unmasked by handgrip exercise is linked with outcomes in (non-) dilated cardiomyopathy
Dynamic mitral regurgitation unmasked by handgrip exercise is linked with outcomes in (non-) dilated cardiomyopathy Open
View article: Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study
Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study Open
Aims Heart failure–related cardiogenic shock (HF‐CS) accounts for about half of CS cases, with a paucity of data regarding the role of kidney injury in this subset. This study aims to evaluate patient characteristics and outcome associated…
View article: Transcatheter Edge-to-Edge Repair in Patients With Primary Tricuspid Regurgitation
Transcatheter Edge-to-Edge Repair in Patients With Primary Tricuspid Regurgitation Open
TEER is a safe and effective option for primary TR, promoting right heart reverse remodeling and symptomatic relief, offering a vital alternative to surgery in selected patients.
View article: Impact of GDMT on outcomes after mitral valve edge-to-edge repair stratified by SMR proportionality
Impact of GDMT on outcomes after mitral valve edge-to-edge repair stratified by SMR proportionality Open
View article: Temporal profiling of M‐TEER‐related complications
Temporal profiling of M‐TEER‐related complications Open
Aims Transcatheter edge‐to‐edge repair of the mitral valve (M‐TEER) is known for its low complication rates. However, the optimal level and duration of post‐procedural care remain unclear. This study aimed to identify the specific timefram…
View article: Exercise‐induced dynamic mitral regurgitation is associated with outcomes in patients with ischaemic cardiomyopathy
Exercise‐induced dynamic mitral regurgitation is associated with outcomes in patients with ischaemic cardiomyopathy Open
Aims Ischaemic mitral regurgitation (MR) is a dynamic condition influenced by global and regional left ventricular remodelling as well as mitral valvular deformation. Exercise testing plays a substantial role in assessing the haemodynamic …
View article: Incidence and predictors of weaning failure from veno‐arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock
Incidence and predictors of weaning failure from veno‐arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock Open
Aims This study aimed to investigate incidence and predictors of weaning failure and in‐hospital death after successful weaning from veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) in patients with cardiogenic shock (CS). Metho…
View article: Outcomes and Impact of Device Iterations in Mitral Valve Transcatheter Edge-to-Edge Repair
Outcomes and Impact of Device Iterations in Mitral Valve Transcatheter Edge-to-Edge Repair Open
Device iterations of the PASCAL system resulted in increasing rates of achieving MR reduction to ≤1+ at discharge, with stable and high technical success rates. A slight deterioration of the initial result warrants further investigation.
View article: Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy
Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy Open
Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated card…
View article: Early Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices—A Propensity Score Matched Multicenter Comparison
Early Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices—A Propensity Score Matched Multicenter Comparison Open
Background/Objectives: Previous trials reported comparable results with PASCAL and earlier MitraClip generations. Limited comparative data exist for more contemporary MitraClip generations, particularly the large MitraClip XT(R/W). We aime…
View article: Amiodarone Administration during Cardiopulmonary Resuscitation Is Not Associated with Changes in Short-Term Mortality or Neurological Outcomes in Cardiac Arrest Patients with Shockable Rhythms
Amiodarone Administration during Cardiopulmonary Resuscitation Is Not Associated with Changes in Short-Term Mortality or Neurological Outcomes in Cardiac Arrest Patients with Shockable Rhythms Open
Background: The search for the best therapeutic approach in cardiopulmonary resuscitations (CPR) remains open to question. In this study, we evaluated if Amiodarone administration during CPR was associated with short-term mortality or neur…
View article: Sex-related differences in patients presenting with heart failure–related cardiogenic shock
Sex-related differences in patients presenting with heart failure–related cardiogenic shock Open
View article: Guideline‐directed medical therapy assessment in heart failure patients undergoing percutaneous mitral valve repair
Guideline‐directed medical therapy assessment in heart failure patients undergoing percutaneous mitral valve repair Open
Aims Achieving optimized guideline‐directed medical therapy (GDMT) is recommended prior to transcatheter mitral valve edge‐to‐edge repair (M‐TEER) for secondary mitral regurgitation (SMR). We aimed to propose and validate an easy‐to‐use sc…
View article: One‐Year Outcomes According to Mitral Regurgitation Etiology Following Transcatheter Edge‐to‐Edge Repair With the PASCAL System: Results From a Multicenter Registry
One‐Year Outcomes According to Mitral Regurgitation Etiology Following Transcatheter Edge‐to‐Edge Repair With the PASCAL System: Results From a Multicenter Registry Open
Background We previously reported procedural and 30‐day outcomes of a German early multicenter experience with the PASCAL system for severe mitral regurgitation (MR). This study reports 1‐year outcomes of mitral valve transcatheter edge‐to…
View article: Association between left ventricular ejection fraction, mortality and use of mechanical circulatory support in patients with non-ischaemic cardiogenic shock
Association between left ventricular ejection fraction, mortality and use of mechanical circulatory support in patients with non-ischaemic cardiogenic shock Open
View article: Handgrip echocardiography predicts clinical outcomes in patients with ischemic mitral regurgitation
Handgrip echocardiography predicts clinical outcomes in patients with ischemic mitral regurgitation Open
Background Mitral regurgitation (MR) is frequent in patients with ischemic heart disease and carries a dismal prognosis. Previous studies already demonstrated the prognostic benefit of bicycle exercise testing in patients with ischemic MR.…
View article: Impact of fast tacrolimus metabolizer status on outcome after heart transplantation
Impact of fast tacrolimus metabolizer status on outcome after heart transplantation Open
Objective Optimal immunosuppression is an essential component of the best possible long-term survival after heart transplantation (HTX). Optimally patient-tailored immunosuppression is standard in Tx follow-up, balancing harmful side effec…
View article: Early outcomes of the PASCAL P10 and the MitraClip XT transcatheter mitral leaflet approximation devices - A propensity score matched multicentre comparison
Early outcomes of the PASCAL P10 and the MitraClip XT transcatheter mitral leaflet approximation devices - A propensity score matched multicentre comparison Open
Background The edge-to-spacer PASCAL repair system was recently approved for percutaneous treatment of severe mitral regurgitation (MR). Comparative data with the MitraClip XT device which shows similar size and leaflet grasping features a…
View article: Validating available Donor-recipient risk assessment tools in a German Heart Transplant cohort
Validating available Donor-recipient risk assessment tools in a German Heart Transplant cohort Open
Objective Several Risk assessment tools have been developed to help predict mortality after heart transplantation. While validated within their regional transplant cohorts, it remains unclear whether they can also be applied to other cohor…
View article: Handgrip echocardiography improves risk stratification in patients with atrial functional mitral regurgitation
Handgrip echocardiography improves risk stratification in patients with atrial functional mitral regurgitation Open
Background In the last years, cardiologist increasingly recognize "atrial functional mitral regurgitation" (AFMR) frequently associated with heart failure with persevered ejection fraction and atrial fibrillation. Exercise echocardiography…
View article: Outcomes of patients undergoing edge‐to‐edge mitral valve repair with the Edwards PASCAL transcatheter valve repair system under conscious sedation
Outcomes of patients undergoing edge‐to‐edge mitral valve repair with the Edwards PASCAL transcatheter valve repair system under conscious sedation Open
Background The development of the PASCAL transcatheter valve repair system for treating mitral regurgitation (MR) greatly extends therapeutic options. Aims To assess the safety, efficacy, and time efficiency of the PASCAL system in transca…
View article: Clinical outcomes of hundred large Impella implantations in cardiogenic shock patients based on individual clinical scenarios
Clinical outcomes of hundred large Impella implantations in cardiogenic shock patients based on individual clinical scenarios Open
Background Large Impella systems (5.0 or 5.5; i.e., Impella 5+) (Abiomed Inc., Danvers, MA, USA) help achieve better clinical outcomes through relevant left ventricular unloading in acute cardiogenic shock (CS). Here, we report our experie…
View article: Comparison of costs associated with transcatheter mitral valve repair: PASCAL vs MitraClip in a real-world setting
Comparison of costs associated with transcatheter mitral valve repair: PASCAL vs MitraClip in a real-world setting Open
View article: Early Postoperative Neurologic Events Are Associated With Worse Outcome and Fatal Midterm Survival After Adult Heart Transplantation
Early Postoperative Neurologic Events Are Associated With Worse Outcome and Fatal Midterm Survival After Adult Heart Transplantation Open
Background Neurologic events during primary stay in heart transplant (HTx) recipients may be associated with reduced outcome and survival, which we aim to explore with the current study. Methods and Results We screened and included all pat…
View article: Reply to Thet et al. Comment on “Oehler et al. Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit. Life 2022, 12, 1053”
Reply to Thet et al. Comment on “Oehler et al. Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit. Life 2022, 12, 1053” Open
Myat Soe Thet et al. published a letter [...]
View article: Lactate to Albumin Ratio for Predicting Clinical Outcomes after In-Hospital Cardiac Arrest
Lactate to Albumin Ratio for Predicting Clinical Outcomes after In-Hospital Cardiac Arrest Open
In-hospital cardiac arrest (IHCA) is associated with high mortality and poor neurological outcomes. Our objective was to assess whether the lactate-to-albumin ratio (LAR) can predict the outcomes in patients after IHCA. We retrospectively …
View article: Lactate versus Phosphate as Biomarkers to Aid Mechanical Circulatory Support Decisions in Patients with Out-of-Hospital Cardiac Arrest and Return of Spontaneous Circulation
Lactate versus Phosphate as Biomarkers to Aid Mechanical Circulatory Support Decisions in Patients with Out-of-Hospital Cardiac Arrest and Return of Spontaneous Circulation Open
Aims: Identifying patients who may benefit from mechanical circulatory support (MCS) after out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC) remains challenging; thus, a search for helpful biomarkers is war…
View article: Use of mechanical circulatory support in patients with non‐ischaemic cardiogenic shock
Use of mechanical circulatory support in patients with non‐ischaemic cardiogenic shock Open
Aims Despite its high incidence and mortality risk, there is no evidence‐based treatment for non‐ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use of mechanical circulatory support (MCS) for non‐ischaemic CS t…
View article: Elevated Initial Serum Phosphate Levels Predict Higher Mortality and Impaired Neurological Outcome in Cardiac Arrest Patients with Return of Spontaneous Circulation
Elevated Initial Serum Phosphate Levels Predict Higher Mortality and Impaired Neurological Outcome in Cardiac Arrest Patients with Return of Spontaneous Circulation Open
Purpose: Although a moderate proportion of cardiac arrest (CA) patients achieve a return of spontaneous circulation (ROSC), few survive to discharge, mostly with poor neurological development. As serum phosphate levels were described as el…