Patrick Imesch
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View article: Endometrial Stromal Cells from Endometriosis Patients Reflect Lesion-Type-Specific Heterogeneity
Endometrial Stromal Cells from Endometriosis Patients Reflect Lesion-Type-Specific Heterogeneity Open
Endometriosis, a disease affecting about one out of ten women, is characterized by the growth of endometrial-like tissue outside the uterine cavity. There is significant disease heterogeneity, but the pathophysiological mechanisms underlyi…
View article: Enhanced analysis of endometriosis patients’ plasma using #Enzian annotation highlights potential biomarkers for early-stages of disease
Enhanced analysis of endometriosis patients’ plasma using #Enzian annotation highlights potential biomarkers for early-stages of disease Open
Endometriosis is a chronic inflammatory condition marked by the presence of endometrial-like tissue outside the uterus, often co-occurring with leiomyoma and presenting a diagnostic challenge. We analyzed 96 plasma cytokines and inflammato…
View article: Artificial intelligence in endometriosis care: A comparative analysis of large language model and human specialist responses to endometriosis-related queries
Artificial intelligence in endometriosis care: A comparative analysis of large language model and human specialist responses to endometriosis-related queries Open
This study found that AI was not inferior to human specialists in answering endometriosis-related queries. While reviewers were able to distinguish AI- from human-generated responses significantly, interrater agreement was only slight. No …
View article: Robotic-assisted laparoscopic niche repair (RALNR): technique development and pregnancy-associated outcomes
Robotic-assisted laparoscopic niche repair (RALNR): technique development and pregnancy-associated outcomes Open
Uterine scar defects after cesarean sections are increasingly common and elevate the risk of life-threatening complications in subsequent pregnancies. From various sonomorphological measurement parameters, the residual myometrial thickness…
View article: Partnership and relationship happiness in endometriosis related chronic pelvic pain: a multicenter case–control study
Partnership and relationship happiness in endometriosis related chronic pelvic pain: a multicenter case–control study Open
Introduction Partnership is an important resource in dealing with endometriosis related chronic pain. Hence, our objective was to assess partnership in the context of endometriosis and its symptoms, considering the perspectives of both ind…
View article: Systematic, noninvasive endometriosis diagnosis in transvaginal sonography by the Swiss Society of Ultrasound in Medicine
Systematic, noninvasive endometriosis diagnosis in transvaginal sonography by the Swiss Society of Ultrasound in Medicine Open
We present a new systematic, comprehensive, checklist-based sonographic assessment of endometriosis in the female true pelvis. Emphasis is placed on practical skills teaching. The newly introduced White Sliding Line (WSL) is the core struc…
View article: MRI-Based Radiomics as a Promising Noninvasive Diagnostic Technique for Adenomyosis
MRI-Based Radiomics as a Promising Noninvasive Diagnostic Technique for Adenomyosis Open
Background: MRI diagnostics are important for adenomyosis, especially in cases with inconclusive ultrasound. This study assessed the potential of MRI-based radiomics as a novel tool for differentiating between uteri with and without adenom…
View article: Evolution of endometriosis research: A comprehensive analysis of research designs and topics over the last 15 years
Evolution of endometriosis research: A comprehensive analysis of research designs and topics over the last 15 years Open
The aim of this review is to analyse the progression of endometriosis research from 2007 to 2022. The PubMed database was searched for publications with titles containing the keyword endometriosis, being created in January and July of the …
View article: Effects of dignity therapy on psychological distress and wellbeing of palliative care patients and family caregivers – a randomized controlled study
Effects of dignity therapy on psychological distress and wellbeing of palliative care patients and family caregivers – a randomized controlled study Open
Background This study extended the original Dignity Therapy (DT) intervention by including partners and family caregivers (FCs) of terminally-ill cancer patients with the overall aim of evaluating whether DT can mitigate distress in both p…
View article: Impact of family history for endometriosis, migraine, depression and early menopause on endometriosis symptoms, localization and stage: A case control study
Impact of family history for endometriosis, migraine, depression and early menopause on endometriosis symptoms, localization and stage: A case control study Open
Around 30% reported a positive FH for migraine or depression. Patients with a positive FH for endometriosis, migraine, depression or EMP differ in symptoms and surgical findings when compared to controls. While a FH for endometriosis is as…
View article: Attitudes and perceptions of affected women towards endocrine endometriosis therapy: an international survey based on free-word association networks
Attitudes and perceptions of affected women towards endocrine endometriosis therapy: an international survey based on free-word association networks Open
STUDY QUESTION What are the attitudes and perceptions towards endocrine endometriosis therapy? SUMMARY ANSWER Among the study population, endocrine endometriosis therapies are associated with negative mental images and emotions and there s…
View article: Endometriosis features and dienogest tolerability in women with depression: a case-control study
Endometriosis features and dienogest tolerability in women with depression: a case-control study Open
EM-D or EM-P had a higher prevalence of pain symptoms. This could not be attributed to differences in rASRM stage or location of endometriosis lesions. Strong primary dysmenorrhoea might predispose to develop chronic pain-based psychologic…
View article: Comparison of male and female perspective in couples involved in sexual relationships and facing endometriosis
Comparison of male and female perspective in couples involved in sexual relationships and facing endometriosis Open
Background While the sexuality of patients with endometriosis is an established topic in research, the possible effect of endometriosis on partnership sexuality has come to the fore only recently. To improve counseling, more information is…
View article: Examining the Influence on Perceptions of Endometriosis via Analysis of Social Media Posts: Cross-sectional Study
Examining the Influence on Perceptions of Endometriosis via Analysis of Social Media Posts: Cross-sectional Study Open
Background Social media platforms, such as Facebook and Instagram, are increasingly being used to share health-related information by “influencers,” regular users, and institutions alike. While patients may benefit in various ways from the…
View article: Living with endometriosis: Comorbid pain disorders, characteristics of pain and relevance for daily life
Living with endometriosis: Comorbid pain disorders, characteristics of pain and relevance for daily life Open
Background Pain plays a central role in endometriosis. The complex relationship among pain characteristics, comorbid pain disorders and daily life represents a challenge for medical support. This multicentre cross‐sectional case–control st…
View article: First case of four spontaneously conceived successful pregnancies after fertility‐sparing surgery for cervical cancer
First case of four spontaneously conceived successful pregnancies after fertility‐sparing surgery for cervical cancer Open
Cervical cancer represents a particular burden when affecting women in their fertile years. Fertility‐sparing surgery such as trachelectomy can maintain a woman`s childbearing ability. Favorable outcomes are possible, as depicted in this c…
View article: Examining the Influence on Perceptions of Endometriosis via Analysis of Social Media Posts: Cross-sectional Study (Preprint)
Examining the Influence on Perceptions of Endometriosis via Analysis of Social Media Posts: Cross-sectional Study (Preprint) Open
BACKGROUND Social media platforms, such as Facebook and Instagram, are increasingly being used to share health-related information by “influencers,” regular users, and institutions alike. While patients may benefit in various ways from th…
View article: Ibrutinib Could Suppress CA-125 in Ovarian Cancer: A Hypothesis
Ibrutinib Could Suppress CA-125 in Ovarian Cancer: A Hypothesis Open
Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, an enzyme central in B cell development. It is indicated as a therapy for certain hematological diseases such as chronic lymphocytic leukemia (CLL), but also exerts off-t…
View article: Ibrutinib in Gynecological Malignancies and Breast Cancer: A Systematic Review
Ibrutinib in Gynecological Malignancies and Breast Cancer: A Systematic Review Open
Ibrutinib is an orally available, small-molecule tyrosine kinase inhibitor. Its main purpose is to inhibit Bruton’s tyrosine kinase (BTK), an enzyme that is crucial in B cell development. It is FDA approved for the treatment of certain hem…
View article: Does endometriosis affect professional life? A matched case-control study in Switzerland, Germany and Austria
Does endometriosis affect professional life? A matched case-control study in Switzerland, Germany and Austria Open
Objectives Endometriosis is a gynaecological disease most commonly causing severe and chronic pelvic pain as well as an impaired quality of life. The aim of this study was to investigate if and how endometriosis affects choices regarding p…
View article: Satisfaction with medical support in women with endometriosis
Satisfaction with medical support in women with endometriosis Open
Endometriosis affects various aspects of women's lives. We searched for predictors for patient satisfaction with medical support (PSwMS) in women with endometriosis. The study was designed as a multi-centre retrospective cohort study. We a…
View article: Fatigue – a symptom in endometriosis
Fatigue – a symptom in endometriosis Open
ClinicalTrials.gov, NCT02511626.
View article: Maltreatment during childhood: a risk factor for the development of endometriosis?
Maltreatment during childhood: a risk factor for the development of endometriosis? Open
Endo_QoL NCT02511626.
View article: Erroneously Suspected Ovarian Cancer in a 38‐Year‐Old Woman with Pelvic Inflammatory Disease and Chlamydia
Erroneously Suspected Ovarian Cancer in a 38‐Year‐Old Woman with Pelvic Inflammatory Disease and Chlamydia Open
Chlamydia trachomatis is the most common bacterial cause of sexually transmitted disease and can cause pelvic inflammatory disease (PID), leading to severe outcomes such as ectopic pregnancy, infertility, or pelvic pain. We report a case o…