Patrick J. Beck
YOU?
Author Swipe
View article: Molecular Basis of Oncogenic PI3K Proteins
Molecular Basis of Oncogenic PI3K Proteins Open
The dysregulation of phosphatidylinositol 3-kinase (PI3K) signaling plays a pivotal role in driving neoplastic transformation by promoting uncontrolled cell survival and proliferation. This oncogenic activity is primarily caused by mutatio…
View article: Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta Open
Resistance to chemotherapies such as temozolomide is a major hurdle to effectively treat therapy-resistant glioblastoma. This challenge arises from the activation of phosphatidylinositol 3-kinase (PI3K), which makes it an appealing therape…
View article: In-hospital triggers of takotsubo syndrome: a case report on witnessing sudden death in a hospital roommate
In-hospital triggers of takotsubo syndrome: a case report on witnessing sudden death in a hospital roommate Open
Background Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, mimicking an acute myocardial infarction, in the absence of obstructed coronary arteries. It is often triggered by physical or emotional stress, wi…
View article: Cannabis Pen-Induced Psychosisin a First-Time Adolescent User.
Cannabis Pen-Induced Psychosisin a First-Time Adolescent User. Open
Cannabis is a widely used illicit substance that is historically consumed via smoking, but alternative methods of cannabis consumption have been growing in popularity over the past several decades. One such modality is vaporization, which …
View article: Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI
Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI Open
Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficultie…
View article: Supplemental Table 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Table 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Inhibitors and Inducers of Autophagy
View article: Supplemental Figure 2 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 2 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Inducing or Inhibiting Early Stage Autophagy Does Not Alter CNL-Induced Cell Death in HNSCC
View article: Supplemental Figure 3 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 3 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Methylpyruvate Partially Rescues from CNL+CQ-driven Autophagic/Mitophagic Response in UNC-10 Cells
View article: Supplemental Figure 4 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 4 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Methylpyruvate Rescues from CNL+CQ-driven Oxidative Stress and Mitochondrial Function in UNC-10 Cells
View article: Data from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Data from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Therapies for head and neck squamous cell carcinoma (HNSCC) are, at best, moderately effective, underscoring the need for new therapeutic strategies. Ceramide treatment leads to cell death as a consequence of mitochondrial damage by genera…
View article: Data from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Data from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Therapies for head and neck squamous cell carcinoma (HNSCC) are, at best, moderately effective, underscoring the need for new therapeutic strategies. Ceramide treatment leads to cell death as a consequence of mitochondrial damage by genera…
View article: Supplemental Figure 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
IC50 Values of CNL-Induced Decreases in Cell Viability at 48 hours in Seven HNSCC Cell Lines and Non-Transformed PGF Cells.
View article: Supplemental Figure 2 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 2 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Inducing or Inhibiting Early Stage Autophagy Does Not Alter CNL-Induced Cell Death in HNSCC
View article: Supplemental Table 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Table 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Inhibitors and Inducers of Autophagy
View article: Supplemental Figure 4 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 4 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Methylpyruvate Rescues from CNL+CQ-driven Oxidative Stress and Mitochondrial Function in UNC-10 Cells
View article: Supplemental Figure 3 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 3 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Methylpyruvate Partially Rescues from CNL+CQ-driven Autophagic/Mitophagic Response in UNC-10 Cells
View article: Supplemental Figure 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Supplemental Figure 1 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
IC50 Values of CNL-Induced Decreases in Cell Viability at 48 hours in Seven HNSCC Cell Lines and Non-Transformed PGF Cells.
View article: Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma Open
Therapies for head and neck squamous cell carcinoma (HNSCC) are, at best, moderately effective, underscoring the need for new therapeutic strategies. Ceramide treatment leads to cell death as a consequence of mitochondrial damage by genera…