Patrick J. Bolan
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View article: Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation
Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation Open
The progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH) involves alterations in both liver-autonomous and systemic metabolism that influence the liver's…
View article: Time‐restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial
Time‐restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial Open
Objective Metabolic improvements may precede weight loss. We compared the effects of self‐selected 8‐h time‐restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, gl…
View article: Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate
Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate Open
The progression of metabolic-dysfunction-associated steatotic liver disease (MASLD) to metabolic-dysfunction-associated steatohepatitis (MASH) involves complex alterations in both liver-autonomous and systemic metabolism that influence the…
View article: Breast Multiparametric MRI for Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer: The BMMR2 Challenge
Breast Multiparametric MRI for Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer: The BMMR2 Challenge Open
Purpose To describe the design, conduct, and results of the Breast Multiparametric MRI for prediction of neoadjuvant chemotherapy Response (BMMR2) challenge. Materials and Methods The BMMR2 computational challenge opened on May 28, 2021, a…
View article: Effect of Longitudinal Variation in Tumor Volume Estimation for MRI-guided Personalization of Breast Cancer Neoadjuvant Treatment
Effect of Longitudinal Variation in Tumor Volume Estimation for MRI-guided Personalization of Breast Cancer Neoadjuvant Treatment Open
Purpose To investigate the impact of longitudinal variation in functional tumor volume (FTV) underestimation and overestimation in predicting pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC). Materials and Methods Wo…
View article: Improved Quantitative Parameter Estimation for Prostate T2 Relaxometry using Convolutional Neural Networks
Improved Quantitative Parameter Estimation for Prostate T2 Relaxometry using Convolutional Neural Networks Open
This work seeks to evaluate multiple methods for quantitative parameter estimation from standard T 2 mapping acquisitions in the prostate. The T 2 estimation performance of methods based on neural networks (NN) was quantitatively compared …
Impact of Alternate b-Value Combinations and Metrics on the Predictive Performance and Repeatability of Diffusion-Weighted MRI in Breast Cancer Treatment: Results from the ECOG-ACRIN A6698 Trial Open
In diffusion-weighted MRI (DW-MRI), choice of b-value influences apparent diffusion coefficient (ADC) values by probing different aspects of the tissue microenvironment. As a secondary analysis of the multicenter ECOG-ACRIN A6698 trial, th…
Liver Volumetry from Magnetic Resonance Images with Convolutional Neural Networks Open
Measurements of liver volume from MR images can be valuable for both clinical and research applications. Automated methods using convolutional neural networks have been used successfully for this using a variety of different MR image types…
View article: Breast MRI during Neoadjuvant Chemotherapy: Lack of Background Parenchymal Enhancement Suppression and Inferior Treatment Response
Breast MRI during Neoadjuvant Chemotherapy: Lack of Background Parenchymal Enhancement Suppression and Inferior Treatment Response Open
Background Suppression of background parenchymal enhancement (BPE) is commonly observed after neoadjuvant chemotherapy (NAC) at contrast-enhanced breast MRI. It was hypothesized that nonsuppressed BPE may be associated with inferior respon…
View article: Training Convolutional Networks for Prostate Segmentation With Limited Data
Training Convolutional Networks for Prostate Segmentation With Limited Data Open
Multi-zonal segmentation is a critical component of computer-aided diagnostic systems for detecting and staging prostate cancer. Previously, convolutional neural networks such as the U-Net have been used to produce fully automatic multi-zo…
A Comparison of Methods for High-Spatial-Resolution Diffusion-weighted Imaging in Breast MRI Open
Background Diffusion-weighted imaging (DWI) shows promise in detecting and monitoring breast cancer, but standard spin-echo (SE) echo-planar DWI methods often have poor image quality and low spatial resolution. Proposed alternatives includ…
View article: Metadata record for the manuscript: Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL
Metadata record for the manuscript: Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL Open
SummaryThis metadata record provides details of the data supporting the claims of the related manuscript: “Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL” The data consist…
View article: Methodological consensus on clinical proton MRS of the brain: Review and recommendations
Methodological consensus on clinical proton MRS of the brain: Review and recommendations Open
Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine…
Test–retest repeatability and reproducibility of ADC measures by breast DWI: Results from the ACRIN 6698 trial Open
Background Quantitative diffusion‐weighted imaging (DWI) MRI is a promising technique for cancer characterization and treatment monitoring. Knowledge of the reproducibility of DWI metrics in breast tumors is necessary to apply DWI as a cli…
MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial Open
1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:290-302.