Explanipedia

Prescription Opioid Use and Change in Generalized Anxiety Disorder Open

Jeffrey F. Scherrer, Adam Metivier, Timothy Chrusciel, Lisa R. Miller‐Matero, Joanne Salas , et al. · 2025

Posttraumatic Stress Disorder and Type 2 Diabetes Outcomes in Veterans Open

Jeffrey F. Scherrer, Joanne Salas, Wenjin Wang, Kenneth E. Freedland, Patrick J. Lustman , et al. · 2024

Importance Posttraumatic stress disorder (PTSD) symptom reduction is linked with lower risk of incident type 2 diabetes (T2D), but little is known about the association between PTSD and comorbid T2D outcomes. Whether PTSD is a modifiable r…

Factors Associated With Interest in Engaging in Psychological Interventions for Pain Management Open

Lisa R. Miller‐Matero, Marissa Yaldo, Sikander Chohan, Celeste Zabel, Shivali Patel , et al. · 2023

Objective: Engagement in evidence-based psychological interventions for pain management is low. Identifying characteristics associated with interest in interventions can inform approaches to increase uptake and engagement. The purpose of t…

Severity of posttraumatic stress disorder, type 2 diabetes outcomes and all-cause mortality: A retrospective cohort study Open

Joanne Salas, Wenjin Wang, Paula P. Schnurr, Beth E. Cohen, Kenneth E. Freedland , et al. · 2023

Characteristics of Patients with Non-Cancer Pain and Perceived Severity of COVID-19 Related Stress. Open

Jeffrey F. Scherrer, Lisa R. Miller‐Matero, Joanne Salas, Mark D. Sullivan, Scott Secrest , et al. · 2022

Depression, anxiety, pain severity, and pain interference were most strongly and consistently associated with COVID-19 changes in way of life, worsening of emotional/mental health, and worsening pain. Identifying specific stressful experie…

PTSD symptom improvement and smoking cessation among a sample of veterans Open

Joanne Salas, Auston Gillis, David Schneider, Jeffrey F. Scherrer, Carissa van den Berk‐Clark , et al. · 2022

Context: Poor health behaviors are common in persons with posttraumatic stress disorder (PTSD). PTSD symptom improvement has been followed by better health behaviors such as medication adherence and use of nutrition, weight loss, and subst…

PTSD improvement and substance use disorder treatment utilization in veterans: Evidence from medical record data Open

Joanne Salas, Sonya B. Norman, Peter W. Tuerk, Carissa van den Berk‐Clark, Beth E. Cohen , et al. · 2020

The Prescription Opioids and Depression Pathways Cohort Study Open

Jeffrey F. Scherrer, Brian K. Ahmedani, Kirsti Autio, Lynn DeBar, Patrick J. Lustman , et al. · 2020

Although the annual number of opioid prescriptions in the United States has decreased, over 190 million patients have OAU each year. If chronic OAU leads to a clinically meaningful affective disorder, independent of pain, then we need to c…

Association Between Clinically Meaningful Posttraumatic Stress Disorder Improvement and Risk of Type 2 Diabetes Open

Jeffrey F. Scherrer, Joanne Salas, Sonya B. Norman, Paula P. Schnurr, Kathleen M. Chard , et al. · 2019

The findings suggest that clinically meaningful reductions in PTSD symptoms are associated with a lower risk of T2D. A decrease in PCL score, whether through treatment or spontaneous improvement, may help mitigate the greater risk of T2D i…

Combined effect of posttraumatic stress disorder and prescription opioid use on risk of cardiovascular disease Open

Jeffrey F. Scherrer, Joanne Salas, Patrick J. Lustman, Peter W. Tuerk, Sarah Gebauer , et al. · 2019

Aim Prescription opioid analgesic use (OAU) is associated with increased risk of cardiovascular disease (CVD). OAU is more common in patients with than without posttraumatic stress disorder (PTSD), and PTSD is associated with higher CVD ri…

Factors Associated With Receipt of Cognitive-Behavioral Therapy or Prolonged Exposure Therapy Among Individuals With PTSD Open

Carissa van den Berk‐Clark, Rachel M. Moore, Scott Secrest, Peter W. Tuerk, Sonya B. Norman , et al. · 2019

TC-CBT initiation increased among patients who were older and female. Initiation was also higher among providers who had more exposure to TC-CBT in their work environment and when TC-CBT fit into their existing workflow.

Comorbid Conditions Explain the Association Between Posttraumatic Stress Disorder and Incident Cardiovascular Disease Open

Jeffrey F. Scherrer, Joanne Salas, Beth E. Cohen, Paula P. Schnurr, David Schneider , et al. · 2019

Background Posttraumatic stress disorder ( PTSD ) is associated with risk of cardiovascular disease ( CVD ). Biopsychosocial factors associated with PTSD likely account for some or all of this association. We determined whether 1, or a com…

The Role of Obesity in the Association Between Posttraumatic Stress Disorder and Incident Diabetes Open

Jeffrey F. Scherrer, Joanne Salas, Patrick J. Lustman, Carissa van den Berk‐Clark, Paula P. Schnurr , et al. · 2018

In this study of patients who use the Veterans Health Administration for health care, obesity moderated the association between PTSD and incident T2DM. The incidence of T2DM in patients with PTSD who are not obese is similar to the nationa…

Impact of adherence to antidepressants on long-term prescription opioid use cessation Open

Jeffrey F. Scherrer, Joanne Salas, Mark D. Sullivan, Brian K. Ahmedani, Laurel A. Copeland , et al. · 2018

Background Depression contributes to persistent opioid analgesic use (OAU). Treating depression may increase opioid cessation. Aims To determine if adherence to antidepressant medications (ADMs) v . non-adherence was associated with opioid…

Gender and the Association between Long-Term Prescription Opioid Use and New-Onset Depression Open

Joanne Salas, Jeffrey F. Scherrer, Brian K. Ahmedani, Laurel A. Copeland, Kathleen K. Bucholz , et al. · 2017

New-onset depression following stable, slow, and rapid rate of prescription opioid dose escalation Open

Joanne Salas, Jeffrey F. Scherrer, David Schneider, Mark D. Sullivan, Kathleen K. Bucholz , et al. · 2016

Recent studies suggest that longer durations of opioid use, independent of maximum morphine equivalent dose (MED) achieved, is associated with increased risk of new-onset depression (NOD). Conversely, other studies, not accounting for dura…

Opioid analgesics and chronic non-cancer pain: a prescription for research in primary care Open

Jeffrey F. Scherrer, David Schneider, Patrick J. Lustman · 2016

Opioid analgesics and chronic non-cancer pain: a prescription for research in primary careThe opioid epidemic in the USA is now reaching other parts of the world (1-3).From 2001 to 2013, opioid use has more than doubled in North America an…

The influence of prescription opioid use duration and dose on development of treatment resistant depression Open

Jeffrey F. Scherrer, Joanne Salas, Mark D. Sullivan, David Schneider, Kathleen K. Bucholz , et al. · 2016

New depression diagnosis following prescription of codeine, hydrocodone or oxycodone Open

Jeffrey F. Scherrer, Joanne Salas, Kathleen K. Bucholz, David Schneider, Thomas E. Burroughs , et al. · 2016

Purpose Longer duration of prescription opioid use is associated with risk of major depression after controlling for daily morphine equivalent dose and pain. It is not known if risk of depression varies as a function of the type of opioid …

Increased Risk of Depression Recurrence After Initiation of Prescription Opioids in Noncancer Pain Patients Open

Jeffrey F. Scherrer, Joanne Salas, Laurel A. Copeland, Eileen M. Stock, David Schneider , et al. · 2016

Antidepressant medication use and glycaemic control in co-morbid type 2 diabetes and depression Open

Jay Brieler, Patrick J. Lustman, Jeffrey F. Scherrer, Joanne Salas, David Schneider · 2016

In this retrospective cohort study of a large sample of primary care patients with type 2 diabetes, ADM use was associated with improved glycaemic control.

Prescription Opioid Duration, Dose, and Increased Risk of Depression in 3 Large Patient Populations Open

Jeffrey F. Scherrer, Joanne Salas, Laurel A. Copeland, Eileen M. Stock, Brian K. Ahmedani , et al. · 2016

Opioid-related new onset of depression is associated with longer duration of use but not dose. Patients and practitioners should be aware that opioid analgesic use of longer than 30 days imposes risk of new-onset depression. Opioid analges…

Change in opioid dose and change in depression in a longitudinal primary care patient cohort Open

Jeffrey F. Scherrer, Joanne Salas, Patrick J. Lustman, Sandra K. Burge, David Schneider · 2015

Depression is associated with receipt of higher doses of prescription opioids. It is not known whether the reverse association exists in that an increased opioid dose is associated with increased depression. Questionnaires were administere…

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