Patrick J. Mulcahey
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View article: Motor Cortical Output Integrates Distorted Proprioceptive Feedback
Motor Cortical Output Integrates Distorted Proprioceptive Feedback Open
Proprioceptive feedback from muscles is essential for continuous monitoring and precise control of limb movement, yet how such peripheral feedback is integrated into ongoing descending motor cortical dynamics remains largely unclear. Here …
View article: Motor priming induces changes in resting state dynamics in cerebellum of writer’s cramp dystonia: insights for clinical therapies
Motor priming induces changes in resting state dynamics in cerebellum of writer’s cramp dystonia: insights for clinical therapies Open
Background Writer’s cramp (WC) is an adult-onset focal dystonia that impairs hand and arm movements during writing tasks. Previous studies have identified abnormal resting state connectivity between the basal ganglia and cerebellum in WC. …
View article: Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia
Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia Open
10 Hz rTMS to PSC improved writing dysfluency by redistributing motor network connectivity and strengthening somatosensory-parietal connectivity. A key signature for effective stimulation at PSC and improvement in writing dysfluency may be…
View article: TMS target comparison identifies motor network reorganization associated with behavioral improvement in writer’s cramp dystonia: A randomized double-blind, sham-controlled clinical trial
TMS target comparison identifies motor network reorganization associated with behavioral improvement in writer’s cramp dystonia: A randomized double-blind, sham-controlled clinical trial Open
View article: Cortico-thalamic communication for action coordination in a skilled motor sequence
Cortico-thalamic communication for action coordination in a skilled motor sequence Open
The coordination of forelimb and orofacial movements to compose an ethological reach-to-consume behavior likely involves neural communication across brain regions. Leveraging wide-field imaging and photo-inhibition to survey across the cor…
View article: Motor network reorganization associated with rTMS-induced writing improvement in writer’s cramp dystonia
Motor network reorganization associated with rTMS-induced writing improvement in writer’s cramp dystonia Open
Background Writer’s cramp (WC) dystonia is an involuntary movement disorder with distributed abnormalities in the brain’s motor network. Prior studies established the potential for repetitive transcranial magnetic stimulation (rTMS) to eit…
View article: <scp>Electroencephalographic</scp> Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders
<span>Electroencephalographic</span> Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders Open
Objective This study was undertaken to characterize quantitative electroencephalographic (EEG) features in participants from the Natural history study of RTT and Related Disorders and to assess the potential for these features to act as ob…
View article: Cortico-thalamic communication for action coordination in a skilled motor sequence
Cortico-thalamic communication for action coordination in a skilled motor sequence Open
SUMMARY The coordination of forelimb and orofacial movements to compose an ethological reach-to-consume behavior likely involves neural communication across brain regions. Leveraging wide-field imaging and photo-inhibition to survey across…
View article: Transcranial magnetic stimulation: the road to clinical therapy for dystonia
Transcranial magnetic stimulation: the road to clinical therapy for dystonia Open
Despite many research studies, transcranial magnetic stimulation (TMS) is not yet an FDA-approved clinical therapy for dystonia patients. This review describes the four major challenges that have historically hindered the clinical translat…
View article: Electrophysiological biomarkers of brain function in CDKL5 deficiency disorder
Electrophysiological biomarkers of brain function in CDKL5 deficiency disorder Open
CDKL5 deficiency disorder is a debilitating developmental and epileptic encephalopathy for which no targeted treatment exists. A number of promising therapeutics are under development for CDKL5 deficiency disorder but a lack of validated b…
View article: Aged heterozygous Cdkl5 mutant mice exhibit spontaneous epileptic spasms
Aged heterozygous Cdkl5 mutant mice exhibit spontaneous epileptic spasms Open
View article: A Gel‐Free Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i>‐Based Electrode Array for High‐Density, High‐Resolution Surface Electromyography
A Gel‐Free Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i>‐Based Electrode Array for High‐Density, High‐Resolution Surface Electromyography Open
Wearable sensors for surface electromyography (EMG) are composed of single‐ to few‐channel large‐area contacts, which exhibit high interfacial impedance and require conductive gels or adhesives to record high‐fidelity signals. These device…