Patrick J. Tu
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View article: Adjunctive β-lactams for <i>Staphylococcus aureus</i> bacteremia: a narrative review
Adjunctive β-lactams for <i>Staphylococcus aureus</i> bacteremia: a narrative review Open
Staphylococcus aureus bacteremia (SAB) remains a major clinical challenge, with persistently high mortality despite advancements in antimicrobial therapy. The evolving epidemiology of SAB, characterized by a rise in community-acquired infe…
View article: Pivmecillinam for Uncomplicated Acute Cystitis: A Contemporary Review
Pivmecillinam for Uncomplicated Acute Cystitis: A Contemporary Review Open
Objective: To review the evidence and discuss use of pivmecillinam in uncomplicated acute cystitis. Data sources: A literature search was conducted utilizing PubMed (from 2000 through August 2024) and ClinicalTrials.gov. Medical Subject He…
View article: Managing Modern Antiretroviral Therapy in the Intensive Care Unit: Overcoming Challenges for Critically Ill People With Human Immunodeficiency Virus
Managing Modern Antiretroviral Therapy in the Intensive Care Unit: Overcoming Challenges for Critically Ill People With Human Immunodeficiency Virus Open
People with human immunodeficiency virus (HIV) have a 50% excess risk for intensive care unit (ICU) admission, often for non-HIV-related conditions. Despite this, clear guidance for managing antiretroviral therapy (ART) in this setting is …
View article: The prevalence of gram-negative bacteria with difficult-to-treat resistance and utilization of novel β-lactam antibiotics in the southeastern United States
The prevalence of gram-negative bacteria with difficult-to-treat resistance and utilization of novel β-lactam antibiotics in the southeastern United States Open
Objective: To evaluate temporal trends in the prevalence of gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) in the southeastern United States. Secondary objective was to examine the use of novel β-lactams for GNB with…
View article: A Case of Infective Endocarditis Caused by <i>Citrobacter koseri</i>: Unraveling a Rare Pathogen and Dire Outcome
A Case of Infective Endocarditis Caused by <i>Citrobacter koseri</i>: Unraveling a Rare Pathogen and Dire Outcome Open
Citrobacter koseri (formerly classified as Citrobacter diversus) is a gram-negative bacillus (GNB) that occurs as an opportunistic pathogen in neonates and immunocompromised patients. Citrobacter species have been implicated in nosocomial …
View article: 408. Benchmarking the Use of New β-lactams Utilizing a Novel Metric of Microbiological Burden
408. Benchmarking the Use of New β-lactams Utilizing a Novel Metric of Microbiological Burden Open
Background Several methods are used to account for various hospital characteristics when comparing antimicrobial use (AU) between heterogenous hospitals. Recently, a new antimicrobial stewardship metric that adjusts AU by microbiological b…
View article: 409. Temporal Trends in Antibiotic Use of New β-lactams for Gram-Negative Bacteria with Difficult-to-Treat Resistance in the Southeastern United States
409. Temporal Trends in Antibiotic Use of New β-lactams for Gram-Negative Bacteria with Difficult-to-Treat Resistance in the Southeastern United States Open
Background Several new β-lactam antibiotics were recently developed for treatment of serious infections due to gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR). This multicenter retrospective cohort study examined temp…
View article: A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications for Hospitalized Patients in 2021
A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications for Hospitalized Patients in 2021 Open
Keeping abreast of the antimicrobial stewardship–related articles published each year is challenging. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship–related, peer-reviewed literature that detailed …