Patrick J. Walsh
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View article: Conjugative Radical–Radical Coupling: Transition-Metal-Free Dialkylation of Alkenes
Conjugative Radical–Radical Coupling: Transition-Metal-Free Dialkylation of Alkenes Open
View article: Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen Open
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their importance, the mechanisms governing LA…
View article: The length and strength of compartmental interactions are modulated by condensin II activity
The length and strength of compartmental interactions are modulated by condensin II activity Open
The spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure …
View article: Sulfenate anion catalyzed enantio- and diastereoselective aziridination
Sulfenate anion catalyzed enantio- and diastereoselective aziridination Open
The first enantioselective sulfenate anion-catalyzed aziridination is developed. High enantio- and diastereoselectivities are obtained with cyclopropyl-substituted imines.
View article: 1,2-Hydrogen atom transfer of aminyl radicals under photoredox catalysis for the synthesis of α-amino phosphine oxides
1,2-Hydrogen atom transfer of aminyl radicals under photoredox catalysis for the synthesis of α-amino phosphine oxides Open
Photocatalytic 1,2-HAT of N-centered radicals leads to C-centered α-amino radicals, with trapping by phosphine oxides to access α-amino phosphine oxides. Mechanistic experiments and DFT calculations support a 1,2-HAT pathway.
View article: Visible-light-driven net-1,2-hydrogen atom transfer of amidyl radicals to access β-amido ketone derivatives
Visible-light-driven net-1,2-hydrogen atom transfer of amidyl radicals to access β-amido ketone derivatives Open
Visible-light-driven N-centered radicals lead to C-centered α-amino radicals through rare net-1,2-HAT processes, with trapping by silyl enol ethers to access β-amido ketone derivatives.
View article: One‐Pot Transition‐Metal‐Free Synthesis of Alkynyl Amides
One‐Pot Transition‐Metal‐Free Synthesis of Alkynyl Amides Open
Alkynyl amides play crucial roles in organic synthesis in the production of bioactive compounds and valuable heterocycles. Despite numerous studies on their synthesis, challenges persist due to the necessity of harsh or hazardous condition…
View article: One‐Pot Transition‐Metal‐Free Synthesis of Alkynyl Amides
One‐Pot Transition‐Metal‐Free Synthesis of Alkynyl Amides Open
Alkynyl amides play crucial roles in organic synthesis in the production of bioactive compounds and valuable heterocycles. Despite numerous studies on their synthesis, challenges persist due to the necessity of harsh or hazardous condition…
View article: One-pot transition-metal-free synthesis of alkynes and enynes
One-pot transition-metal-free synthesis of alkynes and enynes Open
Alkynes are key motifs in chemistry, serving as precursors in many organic reactions toward the synthesis of bioactive compounds, polymers, and new materials. Methods to synthesize terminal alkynes with an extension of the carbon skeleton …
View article: Enantioselective domino alkyl arylation of vinyl phosphonates by combining photoredox and nickel catalysis
Enantioselective domino alkyl arylation of vinyl phosphonates by combining photoredox and nickel catalysis Open
A nickel/photoredox mediated asymmetric domino alkyl arylation of vinyl phosphonates to generate a diverse array of enantioenriched α-aryl phosphonates is disclosed. This asymmetric three-component difunctionalization couples aryl halides …
View article: Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles
Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles Open
Indoles are essential heterocycles in natural products, biological chemistry, and medicinal chemistry. Efficient approaches to their synthesis, therefore, remain in demand. Herein is reported a novel and scalable method to produce a wide v…
View article: CCDC 2293492: Experimental Crystal Structure Determination
CCDC 2293492: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Efficient construction of functionalized pyrroloindolines through cascade radical cyclization/intermolecular coupling
Efficient construction of functionalized pyrroloindolines through cascade radical cyclization/intermolecular coupling Open
A novel tandem radical cyclization/intermolecular coupling between 2-azaallyl anions and indole N -aryloxy acetamides is developed, which enables the synthesis of C3a-substituted pyrroloindolines under mild conditions.
View article: Enantioselective Domino Alkyl Arylation of Vinyl Phosphonates by Combining Photoredox and Nickel Catalysis
Enantioselective Domino Alkyl Arylation of Vinyl Phosphonates by Combining Photoredox and Nickel Catalysis Open
View article: Synthesis of tetraarylmethanes: 1897–2022
Synthesis of tetraarylmethanes: 1897–2022 Open
Tetraarylmethanes (TAMs) contain a carbon atom bound to four aryl groups. They have found diverse applications in chemistry, materials science, chemical biology and medicinal chemistry because of their unique 3-dimensional structures. As a…
View article: CCDC 2173282: Experimental Crystal Structure Determination
CCDC 2173282: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Net-1,2-Hydrogen Atom Transfer of Amidyl Radicals: Toward the Synthesis of 1,2-Diamine Derivatives
Net-1,2-Hydrogen Atom Transfer of Amidyl Radicals: Toward the Synthesis of 1,2-Diamine Derivatives Open
Hydrogen atom transfer (HAT) processes are among the most useful approaches for the selective construction of C(sp3)-C(sp3) bonds. 1,5-HAT with heteroatom-centered radicals (O•, N•) have been wel…
View article: High-throughput Oligopaint screen identifies druggable 3D genome regulators
High-throughput Oligopaint screen identifies druggable 3D genome regulators Open
View article: CCDC 2179563: Experimental Crystal Structure Determination
CCDC 2179563: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Mitotic bookmarking by SWI/SNF subunits
Mitotic bookmarking by SWI/SNF subunits Open
View article: Sulfenate Anion Catalyzed Diastereoselective Synthesis of Aziridines
Sulfenate Anion Catalyzed Diastereoselective Synthesis of Aziridines Open
Aziridines are highly valued synthetic targets in organic and medicinal chemistry. The organocatalytic synthesis of such structures with broad substrate scope and good diastereoselectivity, however, is rare. Herein, we report a broadly app…
View article: Sulfenate Anion Catalyzed Diastereoselective Synthesis of Aziridines
Sulfenate Anion Catalyzed Diastereoselective Synthesis of Aziridines Open
Aziridines are highly valued synthetic targets in organic and medicinal chemistry. The organocatalytic synthesis of such structures with broad substrate scope and good diastereoselectivity, however, is rare. Herein, we report a broadly app…
View article: Recent trends and developments in the asymmetric synthesis of profens
Recent trends and developments in the asymmetric synthesis of profens Open
The profens belong to a class of nonsteroidal anti-inflammatory drugs (NSAIDs), which exert significant anti-inflammatory, analgesic, antipyretic and other pharmacological effects. A considerable number of catalytic asymmetric strategies f…
View article: An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype Open
Three-dimensional genome organization, specifically organization of chromatin at the nuclear periphery, coordinates cell type-specific gene regulation and is critical for maintenance of cell type identity. While various histone modificatio…
View article: Electronically controlled regioselective hydroarylation of gem-difluoroallenes
Electronically controlled regioselective hydroarylation of gem-difluoroallenes Open
All-carbon quaternary centers are ubiquitous structural motifs in natural products, bioactive molecules, and pharmaceuticals. The formation of these crowded carbon centers is well known to be challenging, and methods to access them remain …
View article: α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes
α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes Open
A mild method for the construction of α-branched amine derivatives is presented. SET processes between the Ni catalyst, redox active esters and 2-azaallyl anions generate azaallyl radicals and alkyl radicals that functionalize the alkenes.
View article: Light-mediated aerobic oxidation of C(sp<sup>3</sup>)–H bonds by a Ce(<scp>iv</scp>) hexachloride complex
Light-mediated aerobic oxidation of C(sp<sup>3</sup>)–H bonds by a Ce(<span>iv</span>) hexachloride complex Open
A photochemical C(sp 3 )–H oxygenation of arene and alkane substrates (including methane) catalyzed by [NEt 4 ] 2 [Ce IV Cl 6 ] under mild conditions (1 atm, 25 °C) is described.
View article: Energy-resolved and time-dependent unimolecular dissociation of hydroperoxyalkyl radicals (˙QOOH)
Energy-resolved and time-dependent unimolecular dissociation of hydroperoxyalkyl radicals (˙QOOH) Open
Unimolecular decay of infrared activated hydroperoxyalkyl radicals (˙QOOH) observed via time-resolved appearance of OH radical products.
View article: Energy-resolved and time-dependent unimolecular dissociation of hydroperoxyalkyl radicals (•QOOH)
Energy-resolved and time-dependent unimolecular dissociation of hydroperoxyalkyl radicals (•QOOH) Open
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View article: SET activation of nitroarenes by 2-azaallyl anions as a straightforward access to 2,5-dihydro-1,2,4-oxadiazoles
SET activation of nitroarenes by 2-azaallyl anions as a straightforward access to 2,5-dihydro-1,2,4-oxadiazoles Open