Patrick Janssen
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View article: Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner
Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner Open
Although effects of stress-induced anxiety on the gastrointestinal tract and enteric nervous system (ENS) are well studied, how ENS dysfunction impacts behaviour is not well understood. We investigated whether ENS modulation alters anxiety…
View article: Novel insights into mechanisms of inhibition of colonic motility by loperamide
Novel insights into mechanisms of inhibition of colonic motility by loperamide Open
Background It is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract, particularly the large intestine where constipation is commonly induced. It is n…
View article: Effect of breed and stage of lactation on the solid fat content of milk from cows milked once a day or twice a day
Effect of breed and stage of lactation on the solid fat content of milk from cows milked once a day or twice a day Open
Solid fat content at 10°C (SFC10) is an important parameter of milk fat that influences the spreadability of butter. This study aimed to evaluate the effect of breed and stage of lactation on SFC10 of milk fat from cows milked once a day (…
View article: Association of Single Nucleotide Polymorphism in the DGAT1 Gene with the Fatty Acid Composition of Cows Milked Once and Twice a Day
Association of Single Nucleotide Polymorphism in the DGAT1 Gene with the Fatty Acid Composition of Cows Milked Once and Twice a Day Open
A single nucleotide polymorphism (SNP) rs109421300 of the diacylglycerol acyltransferase 1 (DGAT1) on bovine chromosome 14 is associated with fat yield, fat percentage, and protein percentage. This study aimed to investigate the effect of …
View article: Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model
Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model Open
Gastrointestinal (GI) motility is largely dependent upon activity within the enteric nervous system (ENS) and is an important part of the digestive process. Dysfunction of the ENS can impair GI motility as is seen in the case of constipati…
View article: A Study of Milk Composition and Coagulation Properties of Holstein-Friesian, Jersey, and Their Cross Milked Once or Twice a Day
A Study of Milk Composition and Coagulation Properties of Holstein-Friesian, Jersey, and Their Cross Milked Once or Twice a Day Open
The objective of the study was to explore the effect of breed on the composition and coagulation properties (rennet coagulation time (min), curd firming rate (min), and curd firmness (mm)) of milk from cows milked once a day or twice a day…
View article: Comparing Design Strategies: A System for Optimization-Based Design Exploration
Comparing Design Strategies: A System for Optimization-Based Design Exploration Open
The paper presents a system for supporting optimizationbased design exploration, with a special focus on comparing design strategies for early design stages.The system is developed to facilitate designers to conduct multiple optimization r…
View article: Teaching Computational Design Optimization - An experimental course for performance-based building massing exploration
Teaching Computational Design Optimization - An experimental course for performance-based building massing exploration Open
This paper presents an experimental course focusing on computational design optimization for performance-based building design exploration.The course uses a design system combining a parametric design tool with a cloud-based design evaluat…
View article: Effect of Breed on the Fatty Acid Composition of Milk from Dairy Cows Milked Once and Twice a Day in Different Stages of Lactation
Effect of Breed on the Fatty Acid Composition of Milk from Dairy Cows Milked Once and Twice a Day in Different Stages of Lactation Open
The objective of this study was to evaluate the effect of breed on the overall composition and fatty acid composition of milk from cows milked once a day (OAD) and twice a day (TAD) in different stages of lactation. Milk samples were taken…
View article: Fatty Acid Composition of Dairy Milk: A Case Study Comparing Once- and Twice-a-Day Milking of Pasture-Fed Cows at Different Stages of Lactation
Fatty Acid Composition of Dairy Milk: A Case Study Comparing Once- and Twice-a-Day Milking of Pasture-Fed Cows at Different Stages of Lactation Open
In this case study, we compared the gross composition and fatty acid (FA) composition of milk from cows milked once a day (OAD) and twice a day (TAD) at different stages of lactation in real farm conditions with no control on feed. Seventy…
View article: Participatory Planning: Heritage Conservation Through Co-design and Co-decision
Participatory Planning: Heritage Conservation Through Co-design and Co-decision Open
Citizen participation in urban planning and architectural design has been long discussed and experimented with since the 1960s.With existing participatory design approaches, two key challenges can be identified.First, the power of citizens…
View article: A Rapid Design Optimization Framework - Strategies for the fast evaluation of design options
A Rapid Design Optimization Framework - Strategies for the fast evaluation of design options Open
This paper presents a framework for rapid design optimization, which is aimed to support the iterative design optimization process.The framework consists of Rhino-Grasshopper and an evaluation server.In order to speed up the optimization p…
View article: VR Panoramas - Visualizing urban context using 360 spherical images
VR Panoramas - Visualizing urban context using 360 spherical images Open
VR photography is the interactive viewing of panoramic photographs using a 360° spherical view.This paper focuses on the use of VR photographs of the urban environment to improve spatial understanding.These photographs can be embedded into…
View article: Continuous Adaptability: Web-Based Residential Participatory Design Using Modular Prefabricated Construction
Continuous Adaptability: Web-Based Residential Participatory Design Using Modular Prefabricated Construction Open
High-rise residences are typically very homogeneous and only allow for very limited variability in apartment configurations.Since the 1960s, practitioners and researchers have been exploring alternative visions of adaptable housing solutio…
View article: A centrifugation-based clearing method allows high-throughput acidification and growth-rate measurements in milk
A centrifugation-based clearing method allows high-throughput acidification and growth-rate measurements in milk Open
The turbidity of milk prohibits the use of optical density measurements for strain characterizations. This often limits research to laboratory media. Here, we cleared milk through centrifugation to remove insoluble milk solids. This result…
View article: Mass Participatory Design on the Web - A Voxel-Based 3D Modelling Approach
Mass Participatory Design on the Web - A Voxel-Based 3D Modelling Approach Open
The traditional participatory design approach has its physical limitations regarding the number of workshop participants and visualisation tools used.In order to get the input from more people and to enable three-dimensional design visuali…
View article: P2P Urbanism - Collaborative Generation of Spatial Plans Through Paper Cutting
P2P Urbanism - Collaborative Generation of Spatial Plans Through Paper Cutting Open
This research presents a vision-based Tangible User Interface that was designed to facilitate the investigation of urban spaces.The analogue-digital process made use of inexpensive paper material and commonly accessible technology like a m…
View article: Algorithmic generation of architectural Massing Models for building design optimisation - Parametric Modelling Using Subtractive and Additive Form Generation Principles
Algorithmic generation of architectural Massing Models for building design optimisation - Parametric Modelling Using Subtractive and Additive Form Generation Principles Open
Using performance-based optimisation to explore unknown design solutions space has become widely acknowledged and considered an efficient approach to designing high-performing buildings.However, the lack of design diversity in the design s…
View article: Visual Programming for Geo-COmputation - Towards Tools for Tool Makers
Visual Programming for Geo-COmputation - Towards Tools for Tool Makers Open
The paper presents the Möbius Geospatial Modeller, a web-based visual programming tool developed by the authors for creating interactive 3D geospatial datasets.As an evaluation of the modeller, the results of a five-day workshop are presen…
View article: Progressive Modelling for Parametric Design Optimization - An Example of How Parametric Design Optimization Can Support Reflection
Progressive Modelling for Parametric Design Optimization - An Example of How Parametric Design Optimization Can Support Reflection Open
The use of parametric design optimization should not be merely a solution for design challenges, rather, a medium of reflection.The research explores how to conceive feasible design schemas and formulate appropriate parametric models capab…
View article: Protocols, flows and glitches
Protocols, flows and glitches Open
10.1177/1478077118798934
View article: Cell Surface Properties of Lactococcus lactis Reveal Milk Protein Binding Specifically Evolved in Dairy Isolates
Cell Surface Properties of Lactococcus lactis Reveal Milk Protein Binding Specifically Evolved in Dairy Isolates Open
Surface properties of bacteria are determined by the molecular composition of the cell wall and they are important for interactions of cells with their environment. Well-known examples of bacterial interactions with surfaces are biofilm fo…
View article: Evolutionary Urbanism - Exploring Form-based Codes Using Neuroevolution Algorithms
Evolutionary Urbanism - Exploring Form-based Codes Using Neuroevolution Algorithms Open
Form-Based Codes are legal regulations adopted by local government that allow specific urban forms to be achieved.Such codes have a significant impact on the performative potential of the urban environment.This paper explores the possibili…
View article: Automated Generation of BIM Models
Automated Generation of BIM Models Open
In early stages of architectural design, highly simplified minimal models are often preferred while in the later stages maximal Building Information Models (BIM) are required that include the relevant information for detailed design docume…