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View article: Performance of Tongue Swabs for Tuberculosis Diagnosis in Hospitalized Children Under 5 Years of Age
Performance of Tongue Swabs for Tuberculosis Diagnosis in Hospitalized Children Under 5 Years of Age Open
Background Tuberculosis (TB) diagnosis remains difficult in children under 5 years of age (under-5s), who have high TB morbidity and mortality rates. In a high-burden TB setting, we investigated the diagnostic characteristics of Xpert MTB/…
Smartphones as a platform for molecular analysis: concepts, methods, devices and future potential Open
Smartphones have the potential to transform chemical and biological analysis by functioning as portable, versatile, and democratized platforms for molecular diagnostics. Recent advances in optical detection and devices are reviewed.
View article: Transitioning from night to day transplants: changing the transplant culture for optimisation through a province-wide quality improvement initiative
Transitioning from night to day transplants: changing the transplant culture for optimisation through a province-wide quality improvement initiative Open
Background Organ transplants, some of the most complex operations, have historically been performed overnight due to logistical challenges in healthcare systems. Overnight transplants contribute to transplant team burnout and can compromis…
View article: Adjudication of Codes for Identifying Sepsis in Hospital Administrative Data by Expert Consensus*
Adjudication of Codes for Identifying Sepsis in Hospital Administrative Data by Expert Consensus* Open
OBJECTIVES: Refine the administrative data definition of sepsis in hospitalized patients, including less severe cases. Design and Setting: For each of 1928 infection and 108 organ dysfunction codes used in Canadian hospital abstracts, expe…
Using Physiological Biomarkers to Optimize Management of TBI in Austere Environments Open
Introduction Multimodal monitoring is the use of data from multiple physiological sensors combined in a way to provide individualized patient management. It is becoming commonplace in the civilian care of traumatic brain-injured patients. …
High-Functioning Deceased Donor Kidney Transplant System Characteristics: The British Columbia Experience With an Opt-In System Open
In British Columbia, consent for donation, utilization of donated kidneys, and transplant survival are exceptionally high, suggesting the importance of an integrated deceased donor and kidney transplant service.
Association of Prehospital Neck Wound Survivability and Battlefield Medical Evacuation Time in Afghanistan Open
Introduction The U.S. Military’s Golden Hour policy led to improved warfighter survivability during the Global War on Terror. The policy’s success is well-documented, but a categorical evaluation and stratification of medical evacuation (M…
Market Analysis of Video Laryngoscopy Equipment for the Role 1 Setting Open
Introduction Airway compromise is the second leading cause of potentially preventable prehospital combat death. Endotracheal intubation (ETI) remains the most common role 1 airway intervention. Video laryngoscopy (VL) is superior to direct…
Feasibility of conducting a military-relevant multicenter cohort study to assess outcomes of early trauma resuscitative interventions in a prolonged care civilian setting Open
BACKGROUND The Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study is a 4-year, prospective, observational, large-scale epidemiologic study in South Africa. It will provide novel evidence on how early resuscitation impacts post…
Death determination by neurologic criteria—what do families understand? Open
Family members' understanding of brain death and death determination represented a journey that they reported in sequential meeting with health care providers, most notably physicians. Modifiable factors to improve communication and bereav…
Analysis of the U.S. Military Trauma System in Accordance With Doctrinal Levels of Warfare Open
Introduction In recent conflicts, the Joint Theater Trauma System (JTTS) led the systematic approach to improve battlefield trauma care, substantially contributing to the unprecedented survival of combat casualties. The Joint Trauma System…
View article: Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide
Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide Open
Achromobacter species can cause chronic and potentially severe infections in immunocompromised patients, especially in those with cystic fibrosis. Bacteria cannot be eradicated due to Achromobacter 's intrinsic multidrug resistance.
The epidemiology and outcomes of prolonged trauma care (EpiC) study: methodology of a prospective multicenter observational study in the Western Cape of South Africa Open
Background Deaths due to injuries exceed 4.4 million annually, with over 90% occurring in low-and middle-income countries. A key contributor to high trauma mortality is prolonged trauma-to-treatment time. Earlier receipt of medical care fo…
The experiences of family members of deceased organ donors and suggestions to improve the donation process: a qualitative study Open
We found gaps in family support during end-of-life and donation care. Feelings of abandonment, lack of support and poor-to-little follow-up provide the empirical findings needed for hospitals and organ donor organizations to provide better…
Premortem anticoagulation timing and dose in donation after circulatory death: multicentre study of associations with graft function Open
Premortem heparin is widely used in DCD cases, but there is variability in timing and dose, which was not associated with kidney outcomes in this study. Donor anticoagulation may have a greater impact in preventing biliary complications fo…
View article: Prolonged casualty care: Extrapolating civilian data to the military context
Prolonged casualty care: Extrapolating civilian data to the military context Open
BACKGROUND Civilian and military populations alike are increasingly faced with undesirable situations in which prehospital and definitive care times will be delayed. The Western Cape of South Africa has some similarities in capabilities, i…
View article: Improving quality of withdrawal of life-sustaining measures in organ donation: a framework and implementation toolkit
Improving quality of withdrawal of life-sustaining measures in organ donation: a framework and implementation toolkit Open
The tools developed will aid DCD centres in fulsomely adapting the Canadian Critical Care Society Withdrawal of Life-Sustaining Measures guideline.
Patient-centred and family-centred care of critically ill patients who are potential organ donors: a qualitative study protocol of family member perspectives Open
Introduction In a patient-centred and family-centred approach to organ donation, compassion is paramount. Recent guidelines have called for more research, interventions and approaches aimed at improving and supporting the families of criti…
Farm Management Practices Used by Wheat Producers in the Western Great Plains: Estimating Their Productivity and Profitability Open
Changes in government farm programs and the introduction of new technology offer wheat producers in the western Great Plains a variety of management practices to alleviate biotic and agronomic constraints inherent in a wheat monoculture. P…
View article: Management of the neurologically deceased organ donor: A Canadian clinical practice guideline
Management of the neurologically deceased organ donor: A Canadian clinical practice guideline Open
KEY POINTS Demand for organs continues to exceed their availability, both in Canada and around the world.[1][1] Optimizing the medical management of potential organ donors is an important strategy for enhancing organ supply. The explicit g…
Organ Donation after Medical Assistance in Dying — Canada’s First Cases Open
To the Editor: In 2016, following the Supreme Court of Canada's Carter Decision, 1 medical assistance in dying (MAID became possible with individual court orders.However, owing to the lack of a centrally coordinated Canadian response to th…
View article: Trauma Hemostasis and Oxygenation Research Network position paper on the role of hypotensive resuscitation as part of remote damage control resuscitation
Trauma Hemostasis and Oxygenation Research Network position paper on the role of hypotensive resuscitation as part of remote damage control resuscitation Open
The Trauma Hemostasis and Oxygenation Research (THOR) Network has developed a consensus statement on the role of permissive hypotension in remote damage control resuscitation (RDCR). A summary of the evidence on permissive hypotension foll…
View article: Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors
Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors Open
Introduction Research on the management of deceased organ donors aims to improve the number and quality of transplants and recipient outcomes. In Canada, this research is challenged by regionalisation of donation services within provinces …
View article: Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure
Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure Open
Noninvasive mechanical ventilation (NIV) is widely used in the acute care setting for acute respiratory failure (ARF) across a variety of aetiologies. This document provides European Respiratory Society/American Thoracic Society recommenda…