Patrick Kwan
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View article: Permethrin induces epileptic susceptibility via activation of Na+ channels and rise in glutamate
Permethrin induces epileptic susceptibility via activation of Na+ channels and rise in glutamate Open
Permethrin, a common pyrethroid insecticide, is extensively used to control insect pests and has been widely detected in the environment. A growing body of epidemiological studies has revealed a substantial increase in the prevalence of ep…
View article: Non-invasive neuromodulation for the treatment of drug-resistant epilepsy: Protocol for a systematic review and meta-analysis investigating efficacy, safety, and optimal stimulation parameters
Non-invasive neuromodulation for the treatment of drug-resistant epilepsy: Protocol for a systematic review and meta-analysis investigating efficacy, safety, and optimal stimulation parameters Open
View article: Self‐completed patient‐reported outcome measures in adults with epilepsy: A review
Self‐completed patient‐reported outcome measures in adults with epilepsy: A review Open
Epilepsy affects 65 million people worldwide, and is a World Health Organization priority disease as highlighted in their 2022–2031 Intersectoral Global Action Plan (IGAP) on Epilepsy and other Neurological Disorders. IGAP's objectives inc…
View article: Effects of general anesthetics on seizure termination, mortality, and neurological prognosis in a rat model of pediatric refractory status epilepticus: A comparative randomized controlled study
Effects of general anesthetics on seizure termination, mortality, and neurological prognosis in a rat model of pediatric refractory status epilepticus: A comparative randomized controlled study Open
Our study showed that treatment with GAs effectively terminated RSE and improved survival and short-term cognition. Our proposed model suggests that volatile anesthetics may be the optimal choice for treating RSE. These results may be used…
View article: Neuroimaging abnormalities in functional/dissociative seizures: a meta-analysis
Neuroimaging abnormalities in functional/dissociative seizures: a meta-analysis Open
The neural basis of functional/dissociative seizures represents a significant challenge for psychiatry and neurology. While abnormalities in neuroimaging have been observed, findings across studies remain inconsistent. This systematic revi…
View article: Development and validation of clinico‐imaging machine learning and deep learning models to predict responses to initial antiseizure medications in epilepsy
Development and validation of clinico‐imaging machine learning and deep learning models to predict responses to initial antiseizure medications in epilepsy Open
Objective Antiseizure medications (ASMs) are the first‐line treatment for epilepsy, yet they are ineffective in controlling seizures in about 40% of patients with unpredictable individual response to treatment. This study aimed to develop …
View article: Foundation and Large-Scale AI Models in Neuroscience: A Comprehensive Review
Foundation and Large-Scale AI Models in Neuroscience: A Comprehensive Review Open
The advent of large-scale artificial intelligence (AI) models has a transformative effect on neuroscience research, which represents a paradigm shift from the traditional computational methods through the facilitation of end-to-end learnin…
View article: AI-assisted anti-seizure medication selection? A qualitative study of the views of neurologists and epilepsy patients
AI-assisted anti-seizure medication selection? A qualitative study of the views of neurologists and epilepsy patients Open
PWE and neurologists were supportive of the prospects for MLCDS systems to improve ASM selection for people with epilepsy. However, their support was not unqualified and was often predicated on claims about the nature and role of these sys…
View article: 3607 Promoters and limitations of antiseizure medication adherence from Australian healthcare providers’ perspectives: a qualitative study
3607 Promoters and limitations of antiseizure medication adherence from Australian healthcare providers’ perspectives: a qualitative study Open
View article: 3498 Non-invasive neuromodulation for the treatment of drug-resistant epilepsy: systematic review and meta-analysis investigating efficacy, safety, and optimal stimulation parameters
3498 Non-invasive neuromodulation for the treatment of drug-resistant epilepsy: systematic review and meta-analysis investigating efficacy, safety, and optimal stimulation parameters Open
View article: 3556 Changes in health-related quality of life, mood, and work productivity after first seizure events
3556 Changes in health-related quality of life, mood, and work productivity after first seizure events Open
View article: 3553 A novel patient reported outcome measure for epilepsy: validation of the Seizure-Related Impact Assessment Scale (SERIAS)
3553 A novel patient reported outcome measure for epilepsy: validation of the Seizure-Related Impact Assessment Scale (SERIAS) Open
View article: Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy Open
View article: Effects of cell therapy on seizures in animal models of epilepsy: Systematic review and meta‐analysis
Effects of cell therapy on seizures in animal models of epilepsy: Systematic review and meta‐analysis Open
This study was undertaken to systematically evaluate the efficacy of cell therapy in reducing seizures in animal models of chronic epilepsy. Three databases, Ovid MEDLINE, Ovid Embase, and Web of Science, were searched using predetermined …
View article: Precision medicine for epilepsy: challenges and perspectives for an optimized clinical care pathway
Precision medicine for epilepsy: challenges and perspectives for an optimized clinical care pathway Open
Epilepsies are a common, but heterogeneous group of brain disorders, characterized by an enduring predisposition to recurrent epileptic seizures. Recognizing epilepsies as a disease spectrum offers compelling opportunities to implement pre…
View article: Synthesising Interictal Epileptiform Discharges With Generative Adversarial Network
Synthesising Interictal Epileptiform Discharges With Generative Adversarial Network Open
Interictal epileptiform discharges (IEDs) are reliable biomarkers in electroencephalograms for epilepsy. To automate IED detection, deep learning (DL) has been applied to treat EEG signals as time-series data. However, collecting sufficien…
View article: Association between enlarged perivascular space (<scp>ePVS</scp>) density and stereo‐electroencephalography (<scp>SEEG</scp>) biomarkers of epileptogenicity
Association between enlarged perivascular space (<span>ePVS</span>) density and stereo‐electroencephalography (<span>SEEG</span>) biomarkers of epileptogenicity Open
Objective We aim to explore the association between enlarged perivascular space (ePVS) density and stereo‐electroencephalography (SEEG) biomarkers of epileptogenicity. Methods We retrospectively analyzed consecutive SEEG patients from an A…
View article: Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy
Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy Open
This study highlights that patients with TLE exhibit more pronounced and widespread gray and white matter atrophy across the lifespan. The cross-sectional nature of our study limits definitive conclusions on whether the atrophy shown is pr…
View article: Peripheral cytokine and monocyte phenotype associations in drug-resistant epilepsy
Peripheral cytokine and monocyte phenotype associations in drug-resistant epilepsy Open
Novel therapeutic targets are required to develop new treatments to lower the rates of drug-resistant epilepsy (DRE). This study assessed differences in plasma inflammatory biomarker concentrations and monocyte phenotype and function in pa…
View article: Adapting Biomedical Foundation Models for Predicting Outcomes of Anti Seizure Medications
Adapting Biomedical Foundation Models for Predicting Outcomes of Anti Seizure Medications Open
Epilepsy affects over 50 million people worldwide, with anti-seizure medications (ASMs) as the primary treatment for seizure control. However, ASM selection remains a “trial and error” process due to the lack of reliable predictors of effe…
View article: Facilitators and barriers of antiseizure medication adherence from Australian healthcare providers' perspectives: A qualitative study
Facilitators and barriers of antiseizure medication adherence from Australian healthcare providers' perspectives: A qualitative study Open
Objectives Antiseizure medications (ASMs) are the mainstay of epilepsy treatment. Two‐thirds of people with epilepsy can become seizure‐free with appropriately selected ASMs. Adherence to ASMs is crucial for achieving seizure control. Unfo…
View article: Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications
Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications Open
Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induce…
View article: Validation of the Seizure-Related Impact Assessment Scale
Validation of the Seizure-Related Impact Assessment Scale Open
SERIAS shows good psychometric reliability and strong test-retest stability. These findings suggest that SERIAS is a valid scale to measure epilepsy-related disability.
View article: Predictors of frame-based SEEG electrode implantation accuracy
Predictors of frame-based SEEG electrode implantation accuracy Open
This study analyzed predictive factors of electrode accuracy using a traditional frame-based technique to provide a comprehensive reference. Electrode target radial error is strongly predicted by increased implantation depth, bone thicknes…
View article: The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection
The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection Open
Objective Patient self‐report is known to be an inaccurate reflection of true seizure frequency in persons with epilepsy. The current study aimed to assess the safety and performance of the Minder system, a bilateral subscalp electroenceph…
View article: Serial correlation between saliva and blood beta‐hydroxybutyrate levels in children commencing the ketogenic diet for epilepsy
Serial correlation between saliva and blood beta‐hydroxybutyrate levels in children commencing the ketogenic diet for epilepsy Open
Objectives Accurate and user‐friendly methods to measure beta‐hydroxybutyrate (BHB) concentration are needed to guide the optimal use of ketogenic diet therapy (KDT). We aimed to determine the correlation between serum, capillary, and sali…
View article: Interictal Epileptiform Discharge Detection Using Probabilistic Diffusion Models and AUPRC Maximization
Interictal Epileptiform Discharge Detection Using Probabilistic Diffusion Models and AUPRC Maximization Open
Recently, automated Interictal Epileptiform Discharge (IED) detection has attracted significant attention as a challenging predictive data analysis task aimed at improving early epilepsy diagnosis. Automated IED detection simplifies visual…
View article: Ten‐year projection of adult epilepsy burden in Australia
Ten‐year projection of adult epilepsy burden in Australia Open
Objective The World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders calls for more epilepsy care centers, but a population‐level estimate of epilepsy's projected burden to justify this in…
View article: Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation
Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation Open
The neuronal progenitor NG108-15 neuroblastoma x glioma cell line proliferates indefinitely in vitro and is capable of directed differentiation into cholinergic neurons. The cell line is a robust model for investigating neuronal differenti…
View article: Identification and enrichment of potential pathways in the buffy coat of patients with DRE using non-targeted metabolomics integrated with GEO Datasets
Identification and enrichment of potential pathways in the buffy coat of patients with DRE using non-targeted metabolomics integrated with GEO Datasets Open
The integration of metabolomic data with GEO datasets analysis offers a new strategy to identify robust biomarkers and pathways. The findings obtained from the buffy coat analysis offer potential insights for the diagnosis and treatment of…