Patrick Wagner
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Deep Learning-based Multi Project InP Wafer Simulation for Unsupervised Surface Defect Detection Open
Quality management in semiconductor manufacturing often relies on template matching with known golden standards. For Indium-Phosphide (InP) multi-project wafer manufacturing, low production scale and high design variability lead to such go…
Hematocrit and total protein elimination as quality control parameters of cell salvage Open
Background : The use of cell salvage reduces homologous blood transfusions during operations and avoids associated complications. Therefore, autotransfusion is an integral part of Patient Blood Management (PBM). The quality control of cell…
View article: Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology
Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology Open
Background Intra-tumoral lymphocytes hold prognostic and predictive significance in colorectal cancer (CRC). The internationally validated Immunoscore™ predicts CRC survival risk by averaging percentile scores of tumor-associated CD3 + and…
Primary adrenal sarcomas: A national analysis of epidemiological trends, treatment patterns, and outcomes Open
Background and Objectives Primary adrenal sarcoma (PAS) is an exceedingly rare malignancy with limited data available on its epidemiology, management, and outcomes. This study aimed to characterize the national incidence, treatment pattern…
View article: Intra-pleural and intra-peritoneal tocilizumab therapy for managing malignant pleural effusions and ascites: The Regional Immuno-Oncology Trial (RIOT)−2 study protocol
Intra-pleural and intra-peritoneal tocilizumab therapy for managing malignant pleural effusions and ascites: The Regional Immuno-Oncology Trial (RIOT)−2 study protocol Open
BackgroundMalignant pleural effusions (MPE) and malignant ascites (MA) are serious complications of advanced cancer, marked by debilitating symptoms and limited treatment options. Based on a wealth of previous literature implicating the cy…
View article: Intra-tumoral immunomodulatory therapy for advanced abdominal cancers using lipopolysaccharide: The Regional Immuno-Oncology Trial-1 (RIOT-1) protocol (NCT05751837)
Intra-tumoral immunomodulatory therapy for advanced abdominal cancers using lipopolysaccharide: The Regional Immuno-Oncology Trial-1 (RIOT-1) protocol (NCT05751837) Open
BackgroundIntra-tumoral immunotherapy has shown potential in treating advanced cancers. Delivery challenges have limited exploration of these modalities in intra-abdominal tumors. In this study, we explore the safety of injecting intra-abd…
Deployment Challenges of Industrial Intrusion Detection Systems Open
With the escalating threats posed by cyberattacks on Industrial Control Systems (ICSs), the development of customized Industrial Intrusion Detection Systems (IIDSs) received significant attention in research. While existing literature prop…
Modeling the Effect of Spatial Structure on Solid Tumor Evolution and Circulating Tumor DNA Composition Open
Circulating tumor DNA (ctDNA) monitoring, while sufficiently advanced to reflect tumor evolution in real time and inform cancer diagnosis, treatment, and prognosis, mainly relies on DNA that originates from cell death via apoptosis or necr…
Navigating Precision Oncology: Insights from an Integrated Clinical Data and Biobank Repository Initiative across a Network Cancer Program Open
Advancing cancer treatment relies on the rapid translation of new scientific discoveries to patient care. To facilitate this, an oncology biobank and data repository program, also referred to as the “Moonshot” program, was launched in 2021…
Modeling the effect of spatial structure on solid tumor evolution and ctDNA composition Open
Circulating tumor DNA (ctDNA) monitoring, while sufficiently advanced to reflect tumor evolution in real time and inform on cancer diagnosis, treatment, and prognosis, mainly relies on DNA that originates from cell death via apoptosis or n…
View article: 1506 Comprehensive assessment of lymphocyte counts in colorectal cancer: Defining the optimal prognostic marker
1506 Comprehensive assessment of lymphocyte counts in colorectal cancer: Defining the optimal prognostic marker Open
Background Intra-tumor lymphocyte counts can stratify colorectal cancer (CRC) prognosis and help select patients for and define response to immunotherapy. The internationally validated Immunoscore™ predicts CRC survival risk by averaging p…
Regional Immunotherapy for Peritoneal Carcinomatosis in Gastroesophageal Cancer: Emerging Strategies to Re-Condition a Maladaptive Tumor Environment Open
Peritoneal carcinomatosis originating from gastric/gastroesophageal junction cancer (GC-PC) occurs in a defined subset of gastric cancer patients with unique clinical, pathologic, molecular and immunologic characteristics that create signi…
The Influence of the Microbiome on Immunotherapy for Gastroesophageal Cancer Open
Immunotherapy has shown promise as a treatment option for gastroesophageal cancer, but its effectiveness is limited in many patients due to the immunosuppressive tumor microenvironment (TME) commonly found in gastrointestinal tumors. This …
View article: Freshwater Contributions to Decadal Variability of the Indonesian Throughflow
Freshwater Contributions to Decadal Variability of the Indonesian Throughflow Open
The Makassar Strait, the main passageway of the Indonesian Throughflow (ITF), is an important component of Indo‐Pacific climate through its inter‐basin redistribution of heat and freshwater. Observational studies suggest that wind‐driven f…
Intraoperative molecular imaging: 3rd biennial clinical trials update Open
IMI is a valuable adjunct in precision cancer surgery and has broad applications in multiple subspecialties. It has been reliably used to alter the surgical course of patients and in clinical decision making. There remain gaps in the utili…
PTB-XL (v1.0.1) Soft Segmentations (Delineation) Open
Overview The dataset provides (soft) segmentation/delineation masks for the PTB-XL ECG dataset. The underlying original dataset (v1.0.1) is available from PhysioNet (doi.org/10.13026/kfzx-aw45) For further details on the orginal dataset, c…
PTB-XL (v1.0.1) Soft Segmentations (Delineation) Open
Overview The dataset provides (soft) segmentation/delineation masks for the PTB-XL ECG dataset. The underlying original dataset (v1.0.1) is available from PhysioNet (doi.org/10.13026/kfzx-aw45) For further details on the orginal dataset, c…