Patrick Landback
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View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection Open
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans owing to the technical and ethical complexities of functional s…
View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection. Open
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans due to the technical and ethical complexities of functional stu…
View article: New genes drive the evolution of gene interaction networks in the human and mouse genomes
New genes drive the evolution of gene interaction networks in the human and mouse genomes Open
Our results unveil a remarkable network topological integration process of new genes: over 5000 new genes were integrated into the ancestral GGI networks of human and mouse; new genes gradually acquire increasing number of gene partners; s…
View article: Additional file 13: Table S7. of New genes drive the evolution of gene interaction networks in the human and mouse genomes
Additional file 13: Table S7. of New genes drive the evolution of gene interaction networks in the human and mouse genomes Open
Gene age datasets used in this study. (XLS 5395 kb)