Patrick R. Lawler
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View article: Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the <i>Staphylococcus aureus</i> Network Adaptive Platform (SNAP) randomised controlled trial
Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the <i>Staphylococcus aureus</i> Network Adaptive Platform (SNAP) randomised controlled trial Open
Introduction Many patients receive oral anticoagulation for reduced stroke risk in atrial fibrillation or as treatment or prevention of venous thromboembolism. Oral factor Xa inhibitors (oral FXaI, eg, apixaban, edoxaban or rivaroxaban) ar…
View article: Impact of remote biometric sensing on readmission risk and mortality after hospital discharge: Insights from a Systematic Review and meta‐analysis
Impact of remote biometric sensing on readmission risk and mortality after hospital discharge: Insights from a Systematic Review and meta‐analysis Open
Introduction Unplanned hospital readmissions are associated with higher morbidity, mortality, and financial burden. This study evaluated the association between the use of remote biometric sensing devices (RBS) and all‐cause readmission an…
View article: Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report
Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report Open
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually a…
View article: Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial
Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial Open
Introduction Tocilizumab improves outcomes in critically ill patients with COVID-19. Whether other immune-modulator strategies are equally effective or better is unknown. Methods We investigated treatment with tocilizumab, sarilumab, anaki…
View article: Heart failure decompensation with cardiogenic shock exhibits distinct sequential inflammatory profiles
Heart failure decompensation with cardiogenic shock exhibits distinct sequential inflammatory profiles Open
Aims The inflammatory profile of cardiogenic shock (CS) after myocardial infarction affects outcomes; however, little is known about the impact of inflammatory changes in CS caused by acute decompensated heart failure (ADHF‐CS). We measure…
View article: Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis
Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis Open
Background Statins are considered a promising therapy in traumatic brain injury (TBI) because of their role in mediating inflammatory injury and other endothelial properties. Whether they can improve patient outcomes is unknown. Objectives…
View article: Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials
Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials Open
Dr Sabri Soussi was awarded the Canadian Institutes of Health Research (CIHR) Doctoral Foreign Study Award (DFSA) and the Merit Awards Program (Department of Anesthesiology and Pain Medicine, University of Toronto, Canada) for the current …
View article: Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation Open
Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post–cardiac arrest (CA…
View article: Incidence and Outcomes of Out-of-Hospital Cardiac Arrest Patients Admitted to the Hospital in Canada from 2013 to 2017
Incidence and Outcomes of Out-of-Hospital Cardiac Arrest Patients Admitted to the Hospital in Canada from 2013 to 2017 Open
The age- and sex-standardized incidence of OHCA patients admitted to the hospital, and their survival outcomes, were stable in Canada from 2013 to 2017, with considerable variation noted across geographic regions.
View article: Association between completeness of revascularization and cardiovascular outcomes in patients with diabetes and non-ST elevation myocardial infarction: a population-based registry analysis
Association between completeness of revascularization and cardiovascular outcomes in patients with diabetes and non-ST elevation myocardial infarction: a population-based registry analysis Open
Introduction Approximately one-third of the patients presenting with non-ST elevation myocardial infarction (NSTEMI) have diabetes. From these, two-thirds have multivessel coronary disease. The impact of completeness of revascularization i…
View article: Mortality After Multivessel Revascularization in Patients With Diabetes and Acute Coronary Syndromes
Mortality After Multivessel Revascularization in Patients With Diabetes and Acute Coronary Syndromes Open
While CABG was associated with reduced all-cause mortality compared to multivessel PCI in patients with diabetes and NSTEMI, CABG benefit was seen only against PCI patients potentially ineligible for CABG after receiving a preprocedure sur…
View article: Unsupervised machine learning to identify subphenotypes among cardiac intensive care unit patients with heart failure
Unsupervised machine learning to identify subphenotypes among cardiac intensive care unit patients with heart failure Open
Aims Hospitalized patients with heart failure (HF) are a heterogeneous population, with multiple phenotypes proposed. Prior studies have not examined the biological phenotypes of critically ill patients with HF admitted to the contemporary…
View article: Triage Strategies for Critically Ill Patients With Acute Myocardial Infarction Requiring Invasive Mechanical Ventilation
Triage Strategies for Critically Ill Patients With Acute Myocardial Infarction Requiring Invasive Mechanical Ventilation Open
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View article: Premature Acute Myocardial Infarction Treated With Invasive Revascularization: Comparing STEMI With NSTEMI in a Population-Based Study of Young Patients
Premature Acute Myocardial Infarction Treated With Invasive Revascularization: Comparing STEMI With NSTEMI in a Population-Based Study of Young Patients Open
In young patients with AMI, STEMI was a disproportionately male phenomenon and associated with higher mortality at index hospitalization. One-year and 5-year outcomes were similar among STEMI and NSTEMI patients in those discharged alive a…
View article: The association of antiplatelet agents with mortality among patients with non–COVID-19 community-acquired pneumonia: a systematic review and meta-analysis
The association of antiplatelet agents with mortality among patients with non–COVID-19 community-acquired pneumonia: a systematic review and meta-analysis Open
In hospitalized patients with non-COVID-19 CAP, antiplatelet agents may be associated with reduced mortality compared with usual care or placebo, but the certainty of evidence is low.
View article: Comparison of Bayesian and frequentist monitoring boundaries motivated by the Multiplatform Randomized Clinical Trial
Comparison of Bayesian and frequentist monitoring boundaries motivated by the Multiplatform Randomized Clinical Trial Open
Background The coronavirus disease 2019 pandemic highlighted the need to conduct efficient randomized clinical trials with interim monitoring guidelines for efficacy and futility. Several randomized coronavirus disease 2019 trials, includi…
View article: A comparison of computational algorithms for the Bayesian analysis of clinical trials
A comparison of computational algorithms for the Bayesian analysis of clinical trials Open
Background: Clinical trials are increasingly using Bayesian methods for their design and analysis. Inference in Bayesian trials typically uses simulation-based approaches such as Markov Chain Monte Carlo methods. Markov Chain Monte Carlo h…
View article: Preexisting Diabetes Mellitus and All-Cause Mortality in Adult Patients With Sepsis: A Population-Based Cohort Study
Preexisting Diabetes Mellitus and All-Cause Mortality in Adult Patients With Sepsis: A Population-Based Cohort Study Open
OBJECTIVES: We assessed the association of preexisting diabetes mellitus with all-cause mortality and organ support receipt in adult patients with sepsis. DESIGN: Population-based cohort study. SETTING: Ontario, Canada (2008–2019). POPULAT…
View article: WangLab at MEDIQA-CORR 2024: Optimized LLM-based Programs for Medical Error Detection and Correction
WangLab at MEDIQA-CORR 2024: Optimized LLM-based Programs for Medical Error Detection and Correction Open
Medical errors in clinical text pose significant risks to patient safety. The MEDIQA-CORR 2024 shared task focuses on detecting and correcting these errors across three subtasks: identifying the presence of an error, extracting the erroneo…