Patrick M. Beardsley
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View article: Enantiomeric and Monoaminergic Contributions to Methamphetamine's Bidirectional Effects on Fentanyl-Depressed Respiration in Mice
Enantiomeric and Monoaminergic Contributions to Methamphetamine's Bidirectional Effects on Fentanyl-Depressed Respiration in Mice Open
Rationale: Fentanyl remains the primary cause of fatal overdoses, and its co-use with methamphetamine (METH) is a growing concern. The optical isomers of METH, dextromethamphetamine (d-METH) and levomethamphetamine (l-METH), differ substan…
View article: Amphetamines Exacerbate then Ameliorate Respiratory Effects of Fentanyl as Their Dose Increases
Amphetamines Exacerbate then Ameliorate Respiratory Effects of Fentanyl as Their Dose Increases Open
Background and Purpose: The opioid epidemic remains one of the most pressing public health crises facing the United States. Rising rates of opioid-involved overdose deaths are presently driven primarily by fentanyl and related synthetic op…
View article: Glucocorticoid receptor dysregulation underlies 5-HT<sub>2A</sub>receptor-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model
Glucocorticoid receptor dysregulation underlies 5-HT<sub>2A</sub>receptor-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model Open
Prenatal environmental insults increase the risk of neurodevelopmental psychiatric conditions in the offspring. Structural modifications of dendritic spines are central to brain development and plasticity. Using maternal immune activation …
View article: Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats
Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats Open
The current results suggest that the TAAR1/5-HT1A agonist ulotaront is not likely to pose a risk for recreational abuse in humans and may have potential therapeutic utility as a treatment of substance use disorders.
View article: Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice
Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice Open
Clinical evidence suggests a potential therapeutic effect of classic psychedelics for the treatment of depression. The most outstanding and distinct characteristic is the rapid and sustained antidepressant action with one single exposure t…
View article: Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia
Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia Open
Neurocognitive deficits are a core feature of schizophrenia and, therefore, represent potentially critical outcome variables for assessing antipsychotic treatment response. We performed genome-wide association studies (GWAS) with 492K sing…
View article: Neurochemical Metabolomics Reveals Disruption to Sphingolipid Metabolism Following Chronic Haloperidol Administration
Neurochemical Metabolomics Reveals Disruption to Sphingolipid Metabolism Following Chronic Haloperidol Administration Open
Haloperidol is an effective antipsychotic drug for treatment of schizophrenia, but prolonged use can lead to debilitating side effects. To better understand the effects of long-term administration, we measured global metabolic changes in m…
View article: The <i>ANKS1B</i> Gene and its Associated Phenotypes: Focus on CNS Drug Response
The <i>ANKS1B</i> Gene and its Associated Phenotypes: Focus on CNS Drug Response Open
The ANKS1B gene was a top finding in genome-wide association studies (GWAS) of antipsychotic drug response. Subsequent GWAS findings for ANKS1B include cognitive ability, educational attainment, body mass index, response to corticosteroids…