Patrick Mallon
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View article: Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses: A Deep Review
Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses: A Deep Review Open
Viral metagenomic next-generation sequencing (vmNGS) has transformed our capacity for the untargeted detection and characterisation of (re)emerging zoonotic viruses, surpassing the limitations of traditional targeted diagnostics. In this r…
View article: People living with <scp>HIV</scp> on modern antiretrovirals do not display a pro‐atherogenic lipid profile and have similar body composition compared to healthy controls
People living with <span>HIV</span> on modern antiretrovirals do not display a pro‐atherogenic lipid profile and have similar body composition compared to healthy controls Open
Objectives Alterations in lipids and apolipoproteins contribute to cardiovascular disease (CVD) and are common in people with HIV. The aim of our study was to compare lipid profiles and body composition between people with and without HIV …
View article: Protocol for a core outcome set for pharmacological treatments in hospitalised patients with acute viral respiratory infections (COSAVRI)
Protocol for a core outcome set for pharmacological treatments in hospitalised patients with acute viral respiratory infections (COSAVRI) Open
Background Acute viral respiratory infections (AVRIs) rank among the most common causes of hospitalisation worldwide, imposing significant healthcare burdens and driving the development of pharmacological treatments. However, inconsistent …
View article: Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses
Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses Open
Viral metagenomic next-generation sequencing (vmNGS) has transformed our capacity for the untargeted detection and characterisation of (re)emerging zoonotic viruses, surpassing the limitations of traditional targeted diagnostics. In this r…
View article: Immune Response to MVA-BN Vaccination for Mpox: Current Evidence and Future Directions
Immune Response to MVA-BN Vaccination for Mpox: Current Evidence and Future Directions Open
The 2022 global mpox outbreak, caused by clade IIb of the monkeypox virus (MPXV), prompted emergency use authorisation of the Modified Vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccine, previously approved for smallpox prevention. Understan…
View article: Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination
Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination Open
Background Clade IIb mpox cases have declined globally, likely due to behavioral changes alongside vaccine- and infection-induced immunity. However, infections in vaccinated individuals raise concerns about immunity durability. We compared…
View article: Longitudinal SARS-CoV-2 antibody response in a healthcare worker cohort utilising the Abbott Alinity® anti-nucleocapsid assay
Longitudinal SARS-CoV-2 antibody response in a healthcare worker cohort utilising the Abbott Alinity® anti-nucleocapsid assay Open
Introduction Healthcare workers (HCWs) in Ireland bore a particularly high burden of SARS-CoV-2 infections, representing over 30% of infections during initial waves. We describe the prevalence, incidence and persistence of SARS-CoV-2 anti-…
View article: Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3–5-year period
Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3–5-year period Open
Background: Despite increasing multimorbidity among people with HIV, its impact on health outcomes over time remains uncertain. We explored how distinct multimorbidity patterns affect a broad range of health outcomes over a 3–5-year period…
View article: Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts
Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts Open
Higher circulating SARS-CoV-2 IgG titers correlate with SARS-CoV-2 ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 SARS-C…
View article: Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive
Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive Open
Postacute COVID-19 syndrome (PACS) describes the persistence of symptoms following severe acute respiratory syndrome coronavirus 2 clearance. PACS is sometimes associated with pain and fatigue resembling fibromyalgia syndrome (FMS). Severe…
View article: Associations between type III interferons, obesity and clinical severity of COVID-19
Associations between type III interferons, obesity and clinical severity of COVID-19 Open
Introduction Severe COVID-19 is characterized by hyperimmune host responses contributing to airway damage and acute respiratory distress syndrome. Type III interferons (IFN), including IFN lambda 4 (IFNλ4), expressed in individuals harbori…
View article: Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV
Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV Open
Objectives: There is no consensus definition for multimorbidity. We explored how different frameworks affect multimorbidity patterns and their associations with patient-reported outcomes using the prospective, observational Pharmacokinetic…
View article: Development and validation of a quantitative Orthopoxvirus immunoassay to evaluate and differentiate serological responses to Mpox infection and vaccination
Development and validation of a quantitative Orthopoxvirus immunoassay to evaluate and differentiate serological responses to Mpox infection and vaccination Open
Health Research Board (MONKEYVAX-2022-1), University College Dublin School of Medicine.
View article: Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus
Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus Open
Background Inflammation and innate immune activation are associated with chronic human immunodeficiency virus (HIV) infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, their rela…
View article: Immunogenicity, Reactogenicity and Safety to Assess Booster Vaccinations with BNT162b2 or Full-Dose mRNA-1273 in Adults ≥75 Years (EU-COVAT-1-AGED) – Final Report
Immunogenicity, Reactogenicity and Safety to Assess Booster Vaccinations with BNT162b2 or Full-Dose mRNA-1273 in Adults ≥75 Years (EU-COVAT-1-AGED) – Final Report Open
View article: A psychological model of predictive factors of distress following long COVID
A psychological model of predictive factors of distress following long COVID Open
These findings identify contributing factors to the experience of psychological distress in the long COVID population, providing direction to explore supportive interventions.
View article: Exploring the cascade of mental healthcare among people with <scp>HIV</scp> experiencing depressive symptoms in the UK and Ireland: The <scp>POPPY</scp> study
Exploring the cascade of mental healthcare among people with <span>HIV</span> experiencing depressive symptoms in the UK and Ireland: The <span>POPPY</span> study Open
Introduction Depressive symptoms are highly prevalent among people with HIV, which can negatively impact HIV‐related outcomes. We explore the cascade of mental healthcare for people with HIV experiencing depressive symptoms. Methods People…
View article: HIV, the gut microbiome and clinical outcomes, a systematic review
HIV, the gut microbiome and clinical outcomes, a systematic review Open
Background Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age‐related comorbidities, contributed to by chronic immune activation an…
View article: Learning from post-COVID-19 condition for epidemic preparedness: a variable catalogue for future post-acute infection syndromes
Learning from post-COVID-19 condition for epidemic preparedness: a variable catalogue for future post-acute infection syndromes Open
View article: Patterns and drivers of excess mortality during the COVID-19 pandemic in 13 Western European countries
Patterns and drivers of excess mortality during the COVID-19 pandemic in 13 Western European countries Open
These results suggest the benefit of early implementation of NPIs and swift rollout of vaccines to the most vulnerable. Further analyses are required at a more granular level to better understand how these factors impacted excess mortality…
View article: Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV
Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV Open
Background: We aimed to provide insights into the effects of comorbidities on sleep health in people with HIV by assessing associations between multimorbidity patterns and sleep outcomes in the Pharmacokinetic and clinical Observations in …
View article: Navigating the Landscape of B Cell Mediated Immunity and Antibody Monitoring in SARS-CoV-2 Vaccine Efficacy: Tools, Strategies and Clinical Trial Insights
Navigating the Landscape of B Cell Mediated Immunity and Antibody Monitoring in SARS-CoV-2 Vaccine Efficacy: Tools, Strategies and Clinical Trial Insights Open
Correlates of Protection (CoP) are biomarkers above a defined threshold that can replace clinical outcomes as primary endpoints, predicting vaccine effectiveness to support the approval of new vaccines or follow up studies. In the context …
View article: Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection
Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection Open
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine and relation…
View article: Self‐reported immune status and COVID‐19 associated subjective cognitive functioning in post‐COVID‐19 syndrome: Examination of an Irish cohort
Self‐reported immune status and COVID‐19 associated subjective cognitive functioning in post‐COVID‐19 syndrome: Examination of an Irish cohort Open
Introduction Cognitive changes are very frequently reported by people with post‐COVID‐19 syndrome (PCS), but there is limited understanding of the underpinning mechanisms leading to these difficulties. It is possible that cognitive difficu…
View article: Metabolic Complications Associated with Use of Integrase Strand Transfer Inhibitors (InSTI) for the Treatment of HIV-1 Infection: Focus on Weight Changes, Lipids, Glucose and Bone Metabolism
Metabolic Complications Associated with Use of Integrase Strand Transfer Inhibitors (InSTI) for the Treatment of HIV-1 Infection: Focus on Weight Changes, Lipids, Glucose and Bone Metabolism Open
View article: SARS-CoV-2 Seropositivity in Urban Population of Wild Fallow Deer, Dublin, Ireland, 2020–2022
SARS-CoV-2 Seropositivity in Urban Population of Wild Fallow Deer, Dublin, Ireland, 2020–2022 Open
SARS-CoV-2 can infect wildlife, and SARS-CoV-2 variants of concern might expand into novel animal reservoirs, potentially by reverse zoonosis. White-tailed deer and mule deer of North America are the only deer species in which SARS-CoV-2 h…
View article: Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis
Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis Open
Early inflammatory profiles predicted subsequent maximal disease severity independent of risk factors for severe COVID-19. A cluster with downregulation of growth factors and endothelial activation markers, and early evidence of alveolar e…
View article: Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B)
Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B) Open
A second booster of either BNT162b2 or mRNA-1273 provided substantial IgG increase. Full-dose mRNA-1273 provided higher IgG levels and neutralizing capacity against SARS-CoV-2, with similar safety profile for subjects of advanced age.
View article: Challenges in assessing the immunization status of adults in Germany—lessons from a population-based VACCELERATE survey on polio vaccination
Challenges in assessing the immunization status of adults in Germany—lessons from a population-based VACCELERATE survey on polio vaccination Open
View article: Identification of inflammatory clusters in long-COVID through analysis of plasma biomarker levels
Identification of inflammatory clusters in long-COVID through analysis of plasma biomarker levels Open
Mechanisms underlying long COVID remain poorly understood. Patterns of immunological responses in individuals with long COVID may provide insight into clinical phenotypes. Here we aimed to identify these immunological patterns and study th…