Patrick Massae
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View article: Evolutionary dynamics in the genome of ocular Chlamydia trachomatis strains from Northern Tanzania following mass drug administration
Evolutionary dynamics in the genome of ocular Chlamydia trachomatis strains from Northern Tanzania following mass drug administration Open
Trachoma, caused by Chlamydia trachomatis (Ct), remains a leading cause of preventable infection-induced blindness worldwide. We conducted a 4-year longitudinal study in three trachoma-endemic villages in Northern Tanzania, tracking infect…
View article: Evolutionary Dynamics in the Genome of Ocular Chlamydia trachomatis Strains from Northern Tanzania, pre- and post- Mass Drug Administration
Evolutionary Dynamics in the Genome of Ocular Chlamydia trachomatis Strains from Northern Tanzania, pre- and post- Mass Drug Administration Open
Trachoma, caused by Chlamydia trachomatis (Ct), remains a leading cause of preventable infection induced blindness worldwide. We conducted a four-year longitudinal study in three trachoma-endemic villages in Northern Tanzania, tracking inf…
View article: Evolutionary Dynamics in the Genome of Ocular Chlamydia trachomatis Strains from Northern Tanzania, pre- and post- Mass Drug Administration
Evolutionary Dynamics in the Genome of Ocular Chlamydia trachomatis Strains from Northern Tanzania, pre- and post- Mass Drug Administration Open
Trachoma, caused by Chlamydia trachomatis (Ct), remains a leading cause of preventable infection induced blindness worldwide. We conducted a four-year longitudinal study in three trachoma-endemic villages in Northern Tanzania, tracking inf…
View article: Accuracy, acceptability and feasibility of photography for use in trachoma surveys: a mixed methods study in Tanzania
Accuracy, acceptability and feasibility of photography for use in trachoma surveys: a mixed methods study in Tanzania Open
Background Photography could be used to train individuals to diagnose trachomatous inflammation—follicular (TF) as trachoma prevalence decreases and to ensure accurate field TF grading in trachoma prevalence surveys. We compared photograph…
View article: Longitudinal changes in tear cytokines and antimicrobial proteins in trachomatous disease
Longitudinal changes in tear cytokines and antimicrobial proteins in trachomatous disease Open
Background Trachoma is a neglected tropical disease caused by ocular infection with Chlamydia trachomatis , where repeated infections and chronic inflammation can ultimately result in scarring, trichiasis and blindness. While scarring is t…
View article: Chlamydial positivity of nasal discharge at baseline is associated with ocular chlamydial positivity 2 months following azithromycin treatment
Chlamydial positivity of nasal discharge at baseline is associated with ocular chlamydial positivity 2 months following azithromycin treatment Open
BACKGROUND. Trachoma is the leading infectious cause of blindness. Routes of transmission remain unclear. In this study, the relationship between Chlamydia trachomatis Amplicor-positive nasal discharge and Amplicor-positive ocular swabs wa…
View article: Longitudinal Changes in Tear Cytokines and Antimicrobial Proteins in Trachomatous Disease
Longitudinal Changes in Tear Cytokines and Antimicrobial Proteins in Trachomatous Disease Open
Background Trachoma is a neglected tropical disease caused by ocular infection with Chlamydia trachomatis , where repeated infections and chronic inflammation can ultimately result in scarring, trichiasis and blindness. While scarring is t…
View article: The conjunctival microbiome before and after azithromycin mass drug administration for trachoma control in a cohort of Tanzanian children
The conjunctival microbiome before and after azithromycin mass drug administration for trachoma control in a cohort of Tanzanian children Open
Background Trachoma, caused by ocular infection with Chlamydia trachomatis , is a neglected tropical disease that can lead to blinding pathology. Current trachoma control programmes have successfully used mass drug administration (MDA) wit…
View article: The conjunctival microbiome before and after azithromycin mass drug administration for trachoma control in a cohort of Tanzanian children
The conjunctival microbiome before and after azithromycin mass drug administration for trachoma control in a cohort of Tanzanian children Open
Background Trachoma, caused by ocular infection with Chlamydia trachomatis , is a neglected tropical disease that can lead to blinding pathology. Current trachoma control programmes have successfully used mass drug administration (MDA) wit…
View article: DjinniChip: evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas
DjinniChip: evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas Open
Background The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection, particularly following mass drug administration. Treatment decisions following impact surveys and in post-control …
View article: DjinniChip: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas
DjinniChip: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas Open
Background The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection, particularly following mass drug administration. Treatment decisions following impact surveys and in post-control …
View article: In vivo confocal microscopy and trachomatous conjunctival scarring: Predictors for clinical progression
In vivo confocal microscopy and trachomatous conjunctival scarring: Predictors for clinical progression Open
Importance In vivo confocal microscopy (IVCM) provides high‐resolution images of the ocular surface and has been validated in trachomatous conjunctival scarring. Background This study used IVCM to identify parameters associated with clinic…
View article: DjinniChip: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas
DjinniChip: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas Open
Background The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection, particularly following mass drug administration. Treatment decisions following impact surveys and in post-control …
View article: ClearTrachoma: Evaluation of a Novel Molecular Rapid Diagnostic Device for the Detection of Chlamydia Trachomatis in Trachoma-Endemic Areas
ClearTrachoma: Evaluation of a Novel Molecular Rapid Diagnostic Device for the Detection of Chlamydia Trachomatis in Trachoma-Endemic Areas Open
Background: The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection, particularly following mass drug administration. Treatment decisions following impact surveys and in post-control…
View article: The link between ocular infection with non-chlamydial bacteria and trachomatous eye changes
The link between ocular infection with non-chlamydial bacteria and trachomatous eye changes Open
Introduction Globally, C. trachomatis is the leading infectious cause of blindness. There is evidence to suggest that trachomatous inflammation may be linked to ocular infection with other pathogenic organisms. Methods Conjunctival swab sa…
View article: Immunopathogenesis of Progressive Scarring Trachoma: Results of a 4-Year Longitudinal Study in Tanzanian Children
Immunopathogenesis of Progressive Scarring Trachoma: Results of a 4-Year Longitudinal Study in Tanzanian Children Open
Trachoma is initiated during childhood following repeated conjunctival infection with Chlamydia trachomatis , which causes a chronic inflammatory response in some individuals that leads to scarring and in-turning of the eyelids in later li…
View article: Progression of scarring trachoma in Tanzanian children: A four-year cohort study
Progression of scarring trachoma in Tanzanian children: A four-year cohort study Open
These data suggest that the effect of infection on scarring progression is mediated through papillary inflammation, and that other factors contributing to the development of inflammation, in addition to C. trachomatis infection, may be imp…
View article: Ocular immune responses, Chlamydia trachomatis infection and clinical signs of trachoma before and after azithromycin mass drug administration in a treatment naïve trachoma-endemic Tanzanian community
Ocular immune responses, Chlamydia trachomatis infection and clinical signs of trachoma before and after azithromycin mass drug administration in a treatment naïve trachoma-endemic Tanzanian community Open
Conjunctival inflammation is the major clinical risk factor for progressive scarring trachoma, therefore, the reduction in inflammation associated with azithromycin treatment may be beneficial in limiting the development of potentially bli…
View article: Epidemiology of trachoma and its implications for implementing the “SAFE” strategy in Somali Region, Ethiopia: results of 14 population-based prevalence surveys
Epidemiology of trachoma and its implications for implementing the “SAFE” strategy in Somali Region, Ethiopia: results of 14 population-based prevalence surveys Open
Mass drug administration (MDA) with azithromycin is needed in 13 EUs (population 2,845,818). Two EUs (population 667,599) had TF prevalences in 1-9-year-olds of ≥30% and will require at least 5 years of MDA; 5 EUs (population 1,1193,032) h…
View article: Prevalence of Trachoma in 47 Administrative Districts of Zambia: Results of 32 Population-Based Prevalence Surveys
Prevalence of Trachoma in 47 Administrative Districts of Zambia: Results of 32 Population-Based Prevalence Surveys Open
Trachoma is a public health problem in some parts of Zambia. The Ministry of Health will continue to partner with other stakeholders to implement the multi-sectoral SAFE strategy. Consideration should be given to re-surveying other suspect…
View article: The utility of serology for elimination surveillance of trachoma
The utility of serology for elimination surveillance of trachoma Open
Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpreta…
View article: Non-Chlamydial Bacterial Infection and Progression of Conjunctival Scarring in Trachoma
Non-Chlamydial Bacterial Infection and Progression of Conjunctival Scarring in Trachoma Open
The findings were consistent with the possibility that trachomatous scarring in adults is associated with the presence of non-chlamydial bacterial organisms, particularly pathogenic organisms. C. trachomatis was detected very infrequently …
View article: Immunofibrogenic Gene Expression Patterns in Tanzanian Children with Ocular Chlamydia trachomatis Infection, Active Trachoma and Scarring: Baseline Results of a 4-Year Longitudinal Study
Immunofibrogenic Gene Expression Patterns in Tanzanian Children with Ocular Chlamydia trachomatis Infection, Active Trachoma and Scarring: Baseline Results of a 4-Year Longitudinal Study Open
Trachoma, caused by Chlamydia trachomatis, is the world's leading infectious cause of blindness and remains a significant public health problem. Much of trachomatous disease pathology is thought to be caused indirectly by host cellular and…
View article: Reduced-cost Chlamydia trachomatis-specific multiplex real-time PCR diagnostic assay evaluated for ocular swabs and use by trachoma research programmes
Reduced-cost Chlamydia trachomatis-specific multiplex real-time PCR diagnostic assay evaluated for ocular swabs and use by trachoma research programmes Open
We describe a pipeline from collection to diagnosis providing the most efficient sample preservation and extraction with significant per test cost savings over a commercial qPCR diagnostic assay. The assay and its evaluation should allow c…
View article: miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease
miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease Open
We previously showed that conjunctival miR-147b and miR-1285 were upregulated in Gambian adults with inflammatory scarring trachoma, and miR-155 and miR-184 expression was strongly associated with conjunctival inflammation and ocular Chlam…
View article: Progress of Trachoma Mapping in Mainland Tanzania: Results of Baseline Surveys from 2012 to 2014
Progress of Trachoma Mapping in Mainland Tanzania: Results of Baseline Surveys from 2012 to 2014 Open
Only three districts qualified for mass drug administration with azithromycin. Trichiasis is still a public health problem in many districts, thus community-based trichiasis surgery should be considered to prevent blindness due to trachoma…
View article: Baseline Trachoma Surveys in Kaskazini A and Micheweni Districts of Zanzibar: Results of Two Population-Based Prevalence Surveys Conducted with the Global Trachoma Mapping Project
Baseline Trachoma Surveys in Kaskazini A and Micheweni Districts of Zanzibar: Results of Two Population-Based Prevalence Surveys Conducted with the Global Trachoma Mapping Project Open
Trachoma is a public health problem in Micheweni district, where implementation of all four components of the SAFE strategy (surgery, antibiotics, facial cleanliness, and environmental improvement), including mass drug administration with …
View article: Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data
Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data Open
NKG2C is an activating receptor that is preferentially expressed on natural killer (NK) cells. The gene encoding NKG2C (killer cell lectin-like receptor C2, KLRC2) is present at different copy numbers in the genomes of different individual…