N. Patrick Mayr
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View article: Mid- to long-term outcomes of covered balloon-expandable stent implantation for the management of vascular injuries in patients undergoing transfemoral transcatheter aortic valve implantation: the BE-SAFE Registry
Mid- to long-term outcomes of covered balloon-expandable stent implantation for the management of vascular injuries in patients undergoing transfemoral transcatheter aortic valve implantation: the BE-SAFE Registry Open
Background and aims Vascular complications occur in a non-negligible proportion of transfemoral transcatheter aortic valve implantation (Tf-TAVI) procedures. There is only limited evidence regarding the efficacy and safety of covered ballo…
View article: Comparison of strategies for vascular ACCESS closure after Transcatheter Aortic Valve Implantation: the ACCESS-TAVI randomized trial
Comparison of strategies for vascular ACCESS closure after Transcatheter Aortic Valve Implantation: the ACCESS-TAVI randomized trial Open
Background and Aims Data from randomized trials investigating different access closure strategies after transfemoral transcatheter aortic valve implantation (TF-TAVI) remain scarce. In this study, two vascular closure device (VCD) strategi…
View article: Coagulation after transcatheter aortic valve replacement: Still a black box?
Coagulation after transcatheter aortic valve replacement: Still a black box? Open
Key points Post‐TAVR, there is a significant increase in pro‐coagulatory parameters in conjunction with a decrease in platelet counts. Finding the right balance between thrombosis and bleeding after the procedure is essential, and the resu…
View article: Outcomes after transcatheter mitral valve implantation in valve‐in‐valve, valve‐in‐ring, and valve‐in‐mitral annular calcification
Outcomes after transcatheter mitral valve implantation in valve‐in‐valve, valve‐in‐ring, and valve‐in‐mitral annular calcification Open
Aims We aimed to evaluate transcatheter mitral valve implantation (TMVI) using predominantly balloon‐expandable transcatheter heart valves (THV) in patients with a landing zone for a percutaneously delivered prosthesis. Background Patients…
View article: The Burden of Obesity in Cardiac Surgery: A 14 years’ Follow-Up of 14.754 Patients
The Burden of Obesity in Cardiac Surgery: A 14 years’ Follow-Up of 14.754 Patients Open
Aims. The prevalence of obesity is rapidly increasing during the past decades. While previous research has focused on the early outcome after cardiac surgery or specific complications, the current study covers the whole burden of obesity i…
View article: Efficacy and Safety of Vedolizumab in Patients with Inflammatory Bowel Disease in Association with Vedolizumab Drug Levels
Efficacy and Safety of Vedolizumab in Patients with Inflammatory Bowel Disease in Association with Vedolizumab Drug Levels Open
Background: Vedolizumab (VDZ) is a well-established and important therapeutic option in the treatment of patients with inflammatory bowel disease (IBD). However, the significance of therapeutic drug monitoring (TDM) with VDZ remains a cont…
View article: Anesthetic practice during cardiac implantable electronic device implant procedures: A retrospective, single-center study
Anesthetic practice during cardiac implantable electronic device implant procedures: A retrospective, single-center study Open
Over the years anesthetic practice during CIED implant procedures shifted from mixed anesthetic proceedings to mainly standby duties. The prevalence of complications and emergency measures is low, however not uncommon. Accordingly, the pre…
View article: Individualized targeted treatment in a case of a rare <i>TFG::ROS1</i> fusion positive inflammatory myofibroblastic tumor (IMT)
Individualized targeted treatment in a case of a rare <i>TFG::ROS1</i> fusion positive inflammatory myofibroblastic tumor (IMT) Open
Background Inflammatory myofibroblastic tumor (IMTs) are rare mesenchymal neoplasms with slow growth. Resection is considered as therapeutic standard, with chemotherapy being insufficiently effective in advanced disease. ALK translocations…
View article: Implantation depth of balloon‐expandable transcatheter heart valves and risks for permanent pacemaker implantation and midterm adverse events
Implantation depth of balloon‐expandable transcatheter heart valves and risks for permanent pacemaker implantation and midterm adverse events Open
Background Permanent pacemaker implantation (PPI) remains a relevant complication after transcatheter aortic valve implantation (TAVI) and its impact on outcome remains controversial. Aims This study aimed to analyze the effects of implant…
View article: Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation
Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation Open
Importance Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronary angiography on patients with OHCA with possible coronary trigger but no ST-segment elevation remains uncl…
View article: Fluoroscopic and tomographic correlation for aortic annulus measurements in transcatheter aortic valve implantation: �follow the right cusp� rule
Fluoroscopic and tomographic correlation for aortic annulus measurements in transcatheter aortic valve implantation: �follow the right cusp� rule Open
Introduction and objectives: Coronary computed tomography angiography (CCTA) has become the gold standard to measure the size of the aortic annulus and better select the size of transcatheter heart valves (THV) in patients undergoing trans…
View article: Iliofemoral artery predilation prior to transfemoral transcatheter aortic valve implantation in patients with aortic valve stenosis and advanced peripheral artery disease
Iliofemoral artery predilation prior to transfemoral transcatheter aortic valve implantation in patients with aortic valve stenosis and advanced peripheral artery disease Open
Objectives To investigate the feasibility and safety of percutaneous transluminal angioplasty (PTA) of the iliofemoral arteries (IFA) before transfemoral transcatheter aortic valve implantation (Tf‐TAVI) in patients with advanced periphera…
View article: The impact of extra-valvular cardiac damage on mid-term clinical outcome following transcatheter aortic valve replacement in patients with severe aortic stenosis
The impact of extra-valvular cardiac damage on mid-term clinical outcome following transcatheter aortic valve replacement in patients with severe aortic stenosis Open
Aims To quantify extra-valvular cardiac damage associated with severe aortic valve stenosis (AS), a novel staging model was proposed. This study aimed to validate this model in patients undergoing transcatheter aortic valve replacement (TA…
View article: Progressive multifocal leukoencephalopathy associated with chemotherapy induced lymphocytopenia in solid tumors – case report of an underestimated complication
Progressive multifocal leukoencephalopathy associated with chemotherapy induced lymphocytopenia in solid tumors – case report of an underestimated complication Open
Background JC virus reactivation causing progressive multifocal leukoencephalopathy (PML) occurs preferentially in human immunodeficiency virus (HIV) positive individuals or patients suffering from hematologic neoplasms due to impaired vir…
View article: Successful Urgent TAVI for Critical Aortic Valve Stenosis after ECMO Implantation
Successful Urgent TAVI for Critical Aortic Valve Stenosis after ECMO Implantation Open
Transcatheter aortic valve implantation (TAVI) has evolved to be the treatment of choice for patients with severe aortic stenosis and high perioperative risk. Cardiogenic shock is one of the most severe complications during the TAVI proced…
View article: Correlation between fluoroscopy and tomographic aortic-root measurements in the decision of the transcatheter heart valve size in patients undergoing transcatheter aortic valve implantation
Correlation between fluoroscopy and tomographic aortic-root measurements in the decision of the transcatheter heart valve size in patients undergoing transcatheter aortic valve implantation Open
Introduction and hypothesis Transcatheter aortic valve implantation (TAVI) has become the standard treatment in intermediate and high-risk patients with high degree aortic stenosis (AS).(1–2) These has been also extended to low-risk and yo…
View article: Effects of a dual‐filter‐based cerebral embolic protection device in transcatheter aortic valve replacement on cerebral oxygen saturation: A prospective pilot study
Effects of a dual‐filter‐based cerebral embolic protection device in transcatheter aortic valve replacement on cerebral oxygen saturation: A prospective pilot study Open
Our pilot study revealed no difference in cumulative perioperative cerebral desaturation between TAVR with and without Sentinel-CPS. Catheter- and filter-based manipulations in the brain-supplying arteries for Sentinel-CPS application were…
View article: Antithrombotic therapy with or without clopidogrel after transcatheter aortic valve replacement. A meta-analysis of randomized controlled trials
Antithrombotic therapy with or without clopidogrel after transcatheter aortic valve replacement. A meta-analysis of randomized controlled trials Open
Aims To investigate the clinical outcomes associated with an antithrombotic therapy with or without clopidogrel after transcatheter aortic valve replacement (TAVR). Methods and results This is a study-level meta-analysis including all rand…
View article: Comparison of latest generation supra-annular and intra-annular self-expanding transcatheter heart valves
Comparison of latest generation supra-annular and intra-annular self-expanding transcatheter heart valves Open
The ACURATE neo and the Centera THV show low mortality rates as well as comparable, favorable hemodynamics. The finding of higher stroke rates at 30 days with the repositionable Centera SE-THV needs further assessment.
View article: Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry?
Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry? Open
The prognostic significance of tumor budding in colon cancer is unequivocally documented, and the recommendations of the International Tumor Budding Consensus Conference (ITBCC) are currently the accepted basis for its assessment. Up to no…
View article: Predicting factors for long-term survival in patients with out-of-hospital cardiac arrest – A propensity score-matched analysis
Predicting factors for long-term survival in patients with out-of-hospital cardiac arrest – A propensity score-matched analysis Open
In our study, immediate CAG, ROSC at admission, witnessed arrest and former smoking were independent predictors of survival in cardiac arrest survivors. Improvement in prehospital management including bystander CPR and best practice post-r…
View article: One year VARC-2-defined clinical outcomes after transcatheter aortic valve implantation with the SAPIEN 3
One year VARC-2-defined clinical outcomes after transcatheter aortic valve implantation with the SAPIEN 3 Open
For the first time, VARC-2-defined composite endpoints at 1 year are reported and reveal a considerable proportion of patients experiencing the endpoint of time-related valve safety (29%) and clinical efficacy after 30 days (37%).
View article: Influence of marital status in patients undergoing transcatheter aortic valve implantation
Influence of marital status in patients undergoing transcatheter aortic valve implantation Open
Unmarried patients undergoing TAVI showed a higher incidence of cardiac death or CHF at one year. Hence, marital status should be taken into account in patients with aortic stenosis subjected to TAVI. Whether closer monitoring and intensif…
View article: One‐year clinical outcome with a novel self‐expanding transcatheter heart valve
One‐year clinical outcome with a novel self‐expanding transcatheter heart valve Open
Objectives To evaluate 1‐year outcome using the ACURATE neo (Symetis S.A., a Boston Scientific Company, Ecublens, Switzerland) according to the updated Valve Academic Research Consortium (VARC‐2) with emphasis on the composite endpoints “c…
View article: Assessing the level of radiation experienced by anesthesiologists during transfemoral Transcatheter Aortic Valve Implantation and protection by a lead cap
Assessing the level of radiation experienced by anesthesiologists during transfemoral Transcatheter Aortic Valve Implantation and protection by a lead cap Open
The anesthesiologist's head is exposed to significant radiation during TAVI and it can be protected by wearing a lead-cap.