Patrick McGann
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View article: Hypervirulent Klebsiella pneumoniae causing aortitis retains its capsule and mucoviscosity and remains genotypically and phenotypically stable over time
Hypervirulent Klebsiella pneumoniae causing aortitis retains its capsule and mucoviscosity and remains genotypically and phenotypically stable over time Open
Aortitis due to hypervirulent Klebsiella pneumoniae (hvKp) in a Belarusian male from central New York is described. Isolates at the time of diagnosis (Kp031824-1, Kp031824-2) and after 12 weeks of antimicrobial therapy (Kp070124) were char…
View article: Genomic and phenotypic characterization of respiratory pathogens from CF pediatric patients from Dnipro, Ukraine
Genomic and phenotypic characterization of respiratory pathogens from CF pediatric patients from Dnipro, Ukraine Open
This study highlights the genetic and phenotypic complexity of respiratory pathogens in Ukrainian CF children, emphasizing the emergence of ST398 SCVs and the introduction of hypervirulent K. pneumoniae lineages. The findings call for regu…
View article: Antibiotic resistance characteristics and genetic determinants of hypervirulence in Klebsiella pneumoniae isolated from wounded individuals in Ukraine
Antibiotic resistance characteristics and genetic determinants of hypervirulence in Klebsiella pneumoniae isolated from wounded individuals in Ukraine Open
The study highlights a concerning prevalence of MDR and XDR K. pneumoniae in war-related wound infections in Ukraine, with high-risk international clones (ST307, ST395, ST147, ST23) predominating. These strains exhibit convergent antibioti…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation, but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolate…
View article: Recurring acquisition of carbapenemase genes and global emergence of <i>Pseudomonas aeruginosa</i> ST-1047, a lineage shaped by geopolitical conflicts
Recurring acquisition of carbapenemase genes and global emergence of <i>Pseudomonas aeruginosa</i> ST-1047, a lineage shaped by geopolitical conflicts Open
Pseudomonas aeruginosa sequence type (ST)-1047 is emerging globally as a carbapenemase-rich lineage, yet its evolutionary history and population structure are not known. Here, we performed a comprehensive genomic and epidemiological invest…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolates…
View article: Hypervirulent Klebsiella pneumoniae causing aortitis retains its capsule and mucoviscosity and remains genotypically and phenotypically stable over time
Hypervirulent Klebsiella pneumoniae causing aortitis retains its capsule and mucoviscosity and remains genotypically and phenotypically stable over time Open
Aortitis due to hypervirulent Klebsiella pneumoniae (hvKp) in a Belarusian male from central New York is described. Isolates at the time of diagnosis (Kp031824-1, Kp031824-2) and after 12 weeks of antimicrobial therapy (Kp070124) were char…
View article: An open-source nanopore-only sequencing workflow for analysis of clonal outbreaks delivers short-read level accuracy
An open-source nanopore-only sequencing workflow for analysis of clonal outbreaks delivers short-read level accuracy Open
In this work, we present an optimized nanopore long-read only sequencing workflow for epidemiologic analysis of clonal outbreaks built with open-source tools. A set of unrelated clinical Pseudomonas aeruginosa isolates ( n = 10) was chosen…
View article: Phylogenomics, evolution and origin of multidrug-resistant Acinetobacter baumannii ST15
Phylogenomics, evolution and origin of multidrug-resistant Acinetobacter baumannii ST15 Open
We studied the genomic evolution and transmission dynamics of multidrug-resistant ST15 (Institut Pasteur scheme) Acinetobacter baumannii , examining resistance gene acquisition, clonal diversification, geographic distribution and origin of…
View article: Phenotypic and genotypic analysis of <i>Acinetobacter baumannii</i> isolated from combat wounds in Ukraine during 2022 and 2023
Phenotypic and genotypic analysis of <i>Acinetobacter baumannii</i> isolated from combat wounds in Ukraine during 2022 and 2023 Open
Background Acinetobacter baumannii is an important nosocomial pathogen worldwide. During the current invasion of Ukraine, reports of infections caused by this organism have proliferated. Here, we provide a phenotypic and genotypic analysis…
View article: Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii
Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii Open
The multiply antibiotic-resistant lineage 1 of Acinetobacter baumannii global clone 1 (GC1) emerged in the 1970s, and subsequently more extensively resistant sublineages have emerged. Here, we examined the evolution of the extensively resi…
View article: Genomic analysis of early ST32 <i>Acinetobacter baumannii</i> strains recovered in US military treatment facilities reveals distinct lineages and links to the origins of the Tn<i>6168 ampC</i> transposon
Genomic analysis of early ST32 <i>Acinetobacter baumannii</i> strains recovered in US military treatment facilities reveals distinct lineages and links to the origins of the Tn<i>6168 ampC</i> transposon Open
Objectives To study the population structure and genomic characteristics, including antimicrobial resistance genes, plasmid types and surface polysaccharide type, of the globally distributed Acinetobacter baumannii belonging to ST32 (Insti…
View article: A Step Forward in Hypervirulent <i>Klebsiella pneumoniae</i> Diagnostics
A Step Forward in Hypervirulent <i>Klebsiella pneumoniae</i> Diagnostics Open
Hypervirulent Klebsiella pneumoniae (hvKp) can cause life-threatening infections in healthy community members. HvKp infections often involve multiple sites, some of which are unusual for classical K. pneumoniae (cKp) infections, such as th…
View article: Tn4661-mediated transfer of bla CTX-M-15 from Klebsiella michiganensis to an outbreak clone of Pseudomonas aeruginosa
Tn4661-mediated transfer of bla CTX-M-15 from Klebsiella michiganensis to an outbreak clone of Pseudomonas aeruginosa Open
Carriage of CTX-M-type extended-spectrum β-lactamase (ESBL) is rare in Pseudomonas aeruginosa . During routine surveillance of an endemic ST-621 P. aeruginosa at a large hospital, isolate MRSN 100690 carrying bla CTX-M-15 was cultured from…
View article: Molecular Surveillance of Multidrug-Resistant Bacteria among Refugees from Afghanistan in 2 US Military Hospitals during Operation Allies Refuge, 2021
Molecular Surveillance of Multidrug-Resistant Bacteria among Refugees from Afghanistan in 2 US Military Hospitals during Operation Allies Refuge, 2021 Open
In 2021, two US military hospitals, Landstuhl Regional Medical Center in Landstuhl, Germany, and Walter Reed National Military Medical Center (WRNMMC) in Bethesda, Maryland, USA, observed a high prevalence of multidrug-resistant bacteria a…
View article: Detection of cefiderocol and aztreonam/avibactam resistance in epidemic <i>Escherichia coli</i> ST-361 carrying <i>bla</i> <sub>NDM-5</sub> and <i>bla</i> <sub>KPC-3</sub> from foreign fighters evacuated from Ukraine
Detection of cefiderocol and aztreonam/avibactam resistance in epidemic <i>Escherichia coli</i> ST-361 carrying <i>bla</i> <sub>NDM-5</sub> and <i>bla</i> <sub>KPC-3</sub> from foreign fighters evacuated from Ukraine Open
Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5 , bla KPC-3 , bla CTX-M-15 , and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-…
View article: Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development
Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development Open
This work was supported by NIH R21 AI123558-01 and 1R21AI141826-01A1 (Dr. Russo) and the Department of Veterans Affairs VA Merit Review (I01 BX004677-01) (Dr. Russo). This study was also partially funded by the U.S. Defense Health Program …
View article: Detection of carbapenemase producing Acinetobacter baumannii ST19 from Georgia and Ukraine carrying blaOXA-23, blaOXA-72, and/or blaNDM-5, December 2019 to June 2023
Detection of carbapenemase producing Acinetobacter baumannii ST19 from Georgia and Ukraine carrying blaOXA-23, blaOXA-72, and/or blaNDM-5, December 2019 to June 2023 Open
In 2003−2023, amid 5,436 Acinetobacter baumannii isolates collected globally through the Multidrug-Resistant Organism Repository and Surveillance Network, 97 were ST19 PAS , 34 of which carbapenem-resistant. Strains (n = 32) sampled after …
View article: Distribution and expression of the <i>aac</i>(6′)-<i>Im</i> (<i>aacA16</i>) aminoglycoside resistance gene
Distribution and expression of the <i>aac</i>(6′)-<i>Im</i> (<i>aacA16</i>) aminoglycoside resistance gene Open
Background The aac(6′)-Im (aacA16) amikacin, netilmicin and tobramycin resistance gene cassette had been circulating globally undetected for many years in a sublineage of Acinetobacter baumannii global clone 2. Objectives To identify sourc…
View article: Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine
Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine Open
Objectives To better understand the source and potential transmission routes of antibiotic-resistant bacteria infecting injured service members in Ukraine. Methods Phenotypic and genomic characterizations were performed on 11 Gram-negative…
View article: A Novel Species of Myoviridae Bacteriophages Targets Carbapenem Resistant Acinetobacter baumannii via a Non-capsular Receptor
A Novel Species of Myoviridae Bacteriophages Targets Carbapenem Resistant Acinetobacter baumannii via a Non-capsular Receptor Open
Increasing antimicrobial resistance in Acinetobacter baumannii has resulted in limited to no treatment options. Bacteriophage therapy promises to assist in filling this treatment void. Six related phages (AB1I1L, AB1I1M, AB1I1P, AB1I1T, AB…
View article: Reviewer #2 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Reviewer #2 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 254 isolates…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 254 isolates…
View article: Reviewer #1 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Reviewer #1 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 254 isolates…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation, but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolate…
View article: Differentiation of hypervirulent and classical <i>Klebsiella pneumoniae</i> with acquired drug resistance
Differentiation of hypervirulent and classical <i>Klebsiella pneumoniae</i> with acquired drug resistance Open
Hypervirulent Klebsiella pneumoniae (hvKp) is a concerning pathogen that can cause life-threatening infections in otherwise healthy individuals. Importantly, although strains of hvKp have been acquiring antimicrobial resistance, the effect…