Rajiv Jalan
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View article: GastroGPT: Development and controlled testing of a proof-of-concept customized clinical language model
GastroGPT: Development and controlled testing of a proof-of-concept customized clinical language model Open
Current general-purpose artificial intelligence (AI) large language models (LLMs) demonstrate limited efficacy in clinical medicine, often constrained to question-answering, documentation, and literature summarization roles. We developed G…
View article: Hyperammonemia induces programmed liver cell death
Hyperammonemia induces programmed liver cell death Open
Hyperammonemia is common in liver cirrhosis and causally associated with hepatic encephalopathy development. Little is known about its hepatotoxic effects, which we aimed to characterize in this study. In a mouse model of chronic hyperammo…
View article: Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis Open
Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI is a driver of the most severe forms of ADC, including acute-on-chronic liver failure (ACLF). Blood bioma…
View article: Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK
Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK Open
Liver disease is a major, and increasing, cause of death in the UK. The UK Chronic Liver Failure network (UK-CLIF) was developed as a multi-stakeholder network with the aim to advance cirrhosis research, with emphasis on geographical areas…
View article: Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisation
Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisation Open
There was no funding for the study.
View article: Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis
Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis Open
Patients with acutely decompensated cirrhosis receiving albumin as treatment have a lower incidence of infections. The reason for this protection is currently unknown, but the present study provides data that support the ability of albumin…
View article: Reply: Serological response after COVID-19 vaccination, cirrhosis, and postliver transplant
Reply: Serological response after COVID-19 vaccination, cirrhosis, and postliver transplant Open
We thank Drs Daungsupawong and Wiwanitkit for their insightful comments1 on our manuscript regarding COVID-19 vaccination responses in patients with cirrhosis and postliver transplant.2 They shared several comments: Sample size: The data r…
View article: Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis
Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis Open
Objective Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, …
View article: Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure
Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure Open
Acute-on-chronic liver failure (ACLF), a clinical syndrome that can develop at any stage in the progression of cirrhotic liver disease, is characterized by an acute decompensation in liver function with associated multiorgan failure and hi…
View article: Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant
Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant Open
Background: Vaccine hesitancy and lack of access remain major issues in disseminating COVID-19 vaccination to liver patients globally. Factors predicting poor response to vaccination and risk of breakthrough infection are important data to…
View article: Lessons on brain edema in HE: from cellular to animal models and clinical studies
Lessons on brain edema in HE: from cellular to animal models and clinical studies Open
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are stil…
View article: Development and Clinical Evaluation of AlcoChange: a Digital Therapeutic for Patients with Alcohol-Related Liver Disease
Development and Clinical Evaluation of AlcoChange: a Digital Therapeutic for Patients with Alcohol-Related Liver Disease Open
Background and aims Maintenance of abstinence in alcohol-related liver disease (ARLD) is a major unmet therapeutic need. Digital therapeutics can deliver ongoing behavioural therapy, in real-time, for chronic conditions. The aim of this pr…
View article: Impact of Yaq-001, a non-absorbable, engineered carbon bead of controlled porosity in rodent models of cirrhosis and acute on chronic liver failure
Impact of Yaq-001, a non-absorbable, engineered carbon bead of controlled porosity in rodent models of cirrhosis and acute on chronic liver failure Open
Objective Translocation of gut bacterial lipopolysaccharide (LPS) is associated with complications of cirrhosis. Current strategies to target bacterial translocation are limited to antibiotics with risk of resistance. This study aims to ex…
View article: Review article: Emerging and current management of acute‐on‐chronic liver failure
Review article: Emerging and current management of acute‐on‐chronic liver failure Open
Summary Background Acute‐on‐chronic liver failure (ACLF) is a clinically and pathophysiologically distinct condition from acutely decompensated cirrhosis and is characterised by systemic inflammation, extrahepatic organ failure, and high s…
View article: Extracorporeal liver support and liver transplantation for acute‐on‐chronic liver failure
Extracorporeal liver support and liver transplantation for acute‐on‐chronic liver failure Open
Acute‐on‐chronic liver failure (ACLF) is defined by acute decompensation, organ failure and a high risk of short‐term mortality. This condition is characterized by an overwhelming systemic inflammatory response. Despite treating the precip…
View article: Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure
Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure Open
NCT03065699.