Patrick Mullin
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View article: GDF15 linked to maternal risk of nausea and vomiting during pregnancy
GDF15 linked to maternal risk of nausea and vomiting during pregnancy Open
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full mechanistic understanding is lacking 1–4 . Here we report that f…
View article: Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy
Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy Open
Human pregnancy is frequently accompanied by nausea and vomiting that may become severe and life-threatening, as in hyperemesis gravidarum (HG), the cause of which is unknown. Growth Differentiation Factor-15 (GDF15), a hormone known to ac…
View article: Patterns of Use and Self-reported Effectiveness of Cannabis for Hyperemesis Gravidarum
Patterns of Use and Self-reported Effectiveness of Cannabis for Hyperemesis Gravidarum Open
Introduction There is limited research on effective treatment of Hyperemesis Gravidarum (HG), the most extreme version of nausea and vomiting during pregnancy (NVP). This paper examines current patterns of use and self-reported effectivene…
View article: Whole‐exome sequencing uncovers new variants in <scp><i>GDF15</i></scp> associated with hyperemesis gravidarum
Whole‐exome sequencing uncovers new variants in <span><i>GDF15</i></span> associated with hyperemesis gravidarum Open
Objective A genome‐wide association study (GWAS) linked the placenta and appetite hormone gene GDF15 to hyperemesis gravidarum (HG). This paradigm‐changing finding has shifted the field away from the prevailing hypotheses, but more evidenc…
View article: HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study
HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study Open
Objective Hyperemesis gravidarum (HG) severity can be underestimated resulting in undertreatment and adverse outcomes. This study was conducted to validate a tool (HELP Score) designed to score HG severity. Materials and Methods A survey l…
View article: Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2)
Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2) Open
Hyperemesis Gravidarum (HG), severe nausea/vomiting in pregnancy (NVP), can cause poor maternal/fetal outcomes. Genetic predisposition suggests the genetic component is essential in discovering an etiology. We performed whole-exome sequenc…
View article: Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality
Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality Open
Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and f…
View article: Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum
Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum Open
Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies. It is associated with both maternal and fetal morbidity. HG is highly heritable…
View article: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Open
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studie…
View article: Long-term health effects in children exposed in utero to hyperemesis gravidarum
Long-term health effects in children exposed in utero to hyperemesis gravidarum Open
Objective: Previously we reported on the increased risk of adverse neurodevelopmental outcomes in children exposed in utero to hyperemesis gravidarum.The purpose of this study is to determine the frequency of non-neurodevelopmental long-te…