Patrick N. Cunningham
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View article: Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study
Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study Open
Background. Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease and frequently recurs after kidney transplantation. Recurrent FSGS (rFSGS) is associated with poor allograft and patient outcomes. Bleselum…
View article: Intrarenal B cells integrate<i>in situ</i>innate and adaptive immunity in human renal allograft rejection
Intrarenal B cells integrate<i>in situ</i>innate and adaptive immunity in human renal allograft rejection Open
In human allograft rejection, intrarenal B cell infiltrates identify those with a poor prognosis. However, how intrarenal B cells contribute to rejection is not known. Single cell RNA-sequencing of intrarenal class-switched B cells reveale…
View article: Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers Open
Hypertensive AAs without overt kidney disease who carry 1 or more APOL1 risk variants have a greater BP and albuminuria reduction in response to candesartan therapy. BP response to thiazides or beta blockers did not differ by APOL1 genotyp…
View article: Pharmacogenomics in Hypertension: Where We Stand Today
Pharmacogenomics in Hypertension: Where We Stand Today Open
Hypertension is a common and growing medical problem that leads to enormous cardiovascular and kidney disease worldwide. While many drugs exist to treat hypertension, there is large individual variation in how a given individual responds t…
View article: The Future of Pharmacogenetics in the Treatment of Hypertension
The Future of Pharmacogenetics in the Treatment of Hypertension Open
a streamlined pharmacogenomic approach to get hypertensive patients on the most effective, efficient and well-tolerated drug regimen would be enormously worthwhile.
View article: BER volume 108 issue 4 Cover and Front matter
BER volume 108 issue 4 Cover and Front matter Open
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View article: Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach
Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach Open
Colistin sulfate (polymixin E) is an antibiotic prescribed with increasing frequency for severe Gram-negative bacterial infections. As nephrotoxicity is a common side effect, the discovery of pharmacogenomic markers associated with toxicit…
View article: TNF causes changes in glomerular endothelial permeability and morphology through a Rho and myosin light chain kinase-dependent mechanism
TNF causes changes in glomerular endothelial permeability and morphology through a Rho and myosin light chain kinase-dependent mechanism Open
A key function of the endothelium is to serve as a regulated barrier between tissue compartments. We have previously shown that tumor necrosis factor (TNF) plays a crucial role in lipopolysaccharide (LPS)-induced acute kidney injury, in pa…
View article: C5a alters blood–brain barrier integrity in a human<i>in vitro</i>model of systemic lupus erythematosus
C5a alters blood–brain barrier integrity in a human<i>in vitro</i>model of systemic lupus erythematosus Open
Summary The blood–brain barrier ( BBB ) plays a crucial role in brain homeostasis, thereby maintaining the brain environment precise for optimal neuronal function. Its dysfunction is an intriguing complication of systemic lupus erythematos…
View article: The complement system in lupus nephritis
The complement system in lupus nephritis Open
The complement is part of the innate immune system and can be activated through one of three pathways. To prevent injury of self-tissue, complement is tightly regulated by over 30 proteins. Complement plays dual roles in the pathogenesis o…
View article: Complement in Lupus Nephritis: New Perspectives
Complement in Lupus Nephritis: New Perspectives Open
Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder caused by loss of tolerance to self-antigens, the production of autoantibodies and deposition of complement-fixing immune complexes (ICs) in injured tissues. SLE is c…