Explanipedia

Early detection of Alzheimer’s disease using small RNAs. Results from the EPAD cohort Open

Tobias Sikosek, Marco Heuvelman, Joanna Mika, Mustafa Kahraman, Julia Jehn , et al. · 2025

Integrating small RNA biomarkers with protein-based assays offers preliminary evidence for stratifying MCI, particularly within the amyloid positive continuum. Small nucleolar RNAs and microRNAs warrant further exploration as complementary…

Facilitating Overdose Risk Mitigation Among Patients Following a Clinician Office Closure: A Connecticut Case Study of the Opioid Rapid Response Program Open

Stephanie K. Rubel, Patrick Neubert, Nancy Navarretta, Susan B. Logan · 2022

The Opioid Rapid Response Program (ORRP) is a federal program designed to support states in mitigating risks to patients who lose access to a prescriber of opioids or other controlled substances. Displaced patients might face risks of with…

Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis Open

Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert , et al. · 2022

High Na+ Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils Open

Luka Krampert, K. H. Bauer, Stefan Ebner, Patrick Neubert, Thomas Ossner , et al. · 2021

Infection and inflammation can augment local Na + abundance. These increases in local Na + levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. A…

Effects of mechanical strain on periodontal ligament fibroblasts in presence of Aggregatibacter actinomycetemcomitans lysate Open

Agnes Schröder, Julia Stumpf, Eva Paddenberg, Patrick Neubert, Valentin Schatz , et al. · 2021

Reduction of Tissue Na+ Accumulation After Renal Transplantation Open

Anke Dahlmann, Peter Linz, Isabelle Zucker, Viktor Haag, Jonathan Jantsch , et al. · 2021

Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress Open

Ute Nazet, Patrick Neubert, Valentin Schatz, Susanne Grässel, Peter Proff , et al. · 2021

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes Open

Sabrina Geisberger, Hendrik Bartolomaeus, Patrick Neubert, Ralf Willebrand, Christin Zasada , et al. · 2021

Background: Dietary high salt (HS) is a leading risk factor for mortality and morbidity. Serum sodium transiently increases postprandially but can also accumulate at sites of inflammation affecting differentiation and function of innate an…

Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint Open

Ute Nazet, Laura Feulner, Dominique Muschter, Patrick Neubert, Valentin Schatz , et al. · 2021

Genetic predisposition, traumatic events, or excessive mechanical exposure provoke arthritic changes in the temporomandibular joint (TMJ). We analysed the impact of mechanical stress that might be involved in the development and progressio…

Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity Open

Agnes Schröder, Joshua Gubernator, Alexandra Leikam, Ute Nazet, Fabian Cieplik , et al. · 2021

Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expr…

Impact of salt and the osmoprotective transcription factor NFAT‐5 on macrophages during mechanical strain Open

Agnes Schröder, Alexandra Leikam, Paul Käppler, Patrick Neubert, Jonathan Jantsch , et al. · 2020

Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells‐5 (NFAT‐5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory i…

Hypertonicity counteracts MCL‐1 and renders BCL‐XL a synthetic lethal target in head and neck cancer Open

Sina Heimer, Gertrud Knoll, Patrick Neubert, Karin Hammer, Stefan Wagner , et al. · 2020

Head and neck squamous cell carcinoma (HNSCC) is an aggressive and difficult‐to‐treat cancer entity. Current therapies ultimately aim to activate the mitochondria‐controlled (intrinsic) apoptosis pathway, but complex alterations in intrace…

NCX1 represents an ionic Na+ sensing mechanism in macrophages Open

Patrick Neubert, Arne Homann, David Wendelborn, Anna-Lorena Bär, Luka Krampert , et al. · 2020

Inflammation and infection can trigger local tissue Na(+)accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (M phi s) and their antimicrobial activity. Enhanced Na+-driven M phi func…

Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5 Open

Agnes Schröder, Patrick Neubert, Jens Titze, Aline Bözec, Wolfgang Neuhofer , et al. · 2019

Dietary salt consumption leads to cutaneous Na+ storage and is associated with various disorders, including osteopenia. Here, we explore the impact of Na+ and the osmoprotective transcription factor nuclear factor of activated T cell 5 (NF…

HIF1A and NFAT5 coordinate Na<sup>+</sup>-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting Open

Patrick Neubert, Andrea Weichselbaum, Carmen Reitinger, Valentin Schatz, Agnes Schröder , et al. · 2019

Infection and inflammation are able to induce diet-independent Na⁺-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their anti…

Interplay of Na+ Balance and Immunobiology of Dendritic Cells Open

Patrick Neubert, Agnes Schröder, Dominik N. Müller, Jonathan Jantsch · 2019

Local Na+ balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na+ levels. On the other hand, Na+ availability is able to influence immune responses. In contrast to macrophages, o…

Monitoring Protein Dynamics in Protein O-Mannosyltransferase Mutants In Vivo by Tandem Fluorescent Protein Timers Open

Joan Castells-Ballester, Ewa Zatorska, Matthias Meurer, Patrick Neubert, Anke Metschies , et al. · 2018

For proteins entering the secretory pathway, a major factor contributing to maturation and homeostasis is glycosylation. One relevant type of protein glycosylation is O-mannosylation, which is essential and evolutionarily-conserved in fung…

Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors Open

Simon Sirtl, Gertrud Knoll, Dinh Tuan Anh Trinh, Isabell Lang, Daniela Siegmund , et al. · 2018

Attempts to exploit the cytotoxic activity of death receptors (DR) for treating cancer have thus far been disappointing. DR activation in most malignant cells fails to trigger cell death and may even promote tumor growth by activating cell…

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses Open

Valentin Schatz, Patrick Neubert, Franz Rieger, Jonathan Jantsch · 2018

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which me…

Salt-responsive gut commensal modulates TH17 axis and disease Open

Nicola Wilck, Mariana Matus, Sean M. Kearney, Scott W. Olesen, Sofia K. Forslund , et al. · 2017

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation Open

Kento Kitada, Steffen Daub, Xiaoyan Zhang, Janet D. Klein, Daisuke Nakano , et al. · 2017

Natriuretic regulation of extracellular fluid volume homeostasis includes suppression of the renin-angiotensin-aldosterone system, pressure natriuresis, and reduced renal nerve activity, actions that concomitantly increase urinary Na+ excr…

Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging Open

Christoph Kopp, Christian Beyer, Peter Linz, Anke Dahlmann, Matthias Hammon , et al. · 2017

Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging Open

Christoph Kopp, Christian Beyer, Peter Linz, Anke Dahlmann, Matthias Hammon , et al. · 2016

23 Na-MRI detected increased Na + in the fibrotic SSc skin; high Na + content was associated with progressive skin disease. Our findings provide the first evidence that 23 Na-MRI might be a promising tool to assess skin Na + and thereby pr…

Elementary immunology: Na+ as a regulator of immunity Open

Valentin Schatz, Patrick Neubert, Agnes Schröder, Katrina J. Binger, Matthias Gebhard , et al. · 2016

The skin can serve as an interstitial Na⁺ reservoir. Local tissue Na⁺ accumulation increases with age, inflammation and infection. This increased local Na⁺ availability favors pro-inflammatory immune cell f…

Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae Open

Patrick Neubert, Adnan Halim, Martin Zauser, Andreas Essig, Hiren J. Joshi , et al. · 2016

The transcription factor SOX11 is a potential tumor suppressor in myxoid liposarcomas: Analysis of function, target genes and mutation Open

Patrick Neubert · 2016

Soft tissue sarcomas are a rare group of highly aggressive, histologically and genetically heterogeneous malignant tumors of mesenchymal origin. Liposarcomas are the most common type of sarcomas and are classified into the three types well…

Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast Open

Adnan Halim, Ida Signe Bohse Larsen, Patrick Neubert, Hiren J. Joshi, Bent Larsen Petersen , et al. · 2015

Significance Nucleocytoplasmic dynamic cycling of N -Acetylglucosamine (GlcNAc) on serine and threonine residues (O-GlcNAcylation) and phosphorylation coregulate important cellular processes in all eukaryotic organisms except yeast, includ…

Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense Open

Jonathan Jantsch, Valentin Schatz, Diana Friedrich, Agnes Schröder, Christoph Kopp , et al. · 2015

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