Patrick Neuhoefer
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View article: 1166 Profiling the effects of targeted TLR9 stimulation within spontaneously arising breast tumors
1166 Profiling the effects of targeted TLR9 stimulation within spontaneously arising breast tumors Open
Background Tumor-localized delivery of immune-stimulants, such as Toll-like receptor (TLR) agonists, is a promising strategy to treat various cancer types, including immunologically "cold" tumors that lack T cell infiltration. Immunostimul…
View article: 768 Systemic delivery of a tumor-targeted TLR9 agonist conjugate transforms the tumor immune landscape and induces tumor regression in mice
768 Systemic delivery of a tumor-targeted TLR9 agonist conjugate transforms the tumor immune landscape and induces tumor regression in mice Open
Background Tumor-localized delivery of Toll-like receptor (TLR) agonists is a promising strategy to promote immune activation within the tumor microenvironment (TME) to overcome tumor immunosuppression and induce anti-tumor immune response…