Patrick O. McGowan
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View article: What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review
What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review Open
Background: Parent depression is a well-established prospective risk factor for adverse offspring mental health. Multiple lines of evidence suggest that improvements in parent depression predicts improved offspring mental health. However, …
Milk derived extracellular vesicle uptake in human microglia regulates the DNA methylation machinery Open
Mammalian milk contains milk-derived extracellular vesicles (MEVs), a group of biological nanovesicles that transport macromolecules. Their ability to cross the blood brain barrier and the presence of cargo capable of modifying gene functi…
Cell-type-specific epigenetic effects of early life stress on the brain Open
Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNA…
Hippocampus-Anterior Hypothalamic Circuit Modulates Stress-Induced Endocrine and Behavioral Response Open
Hippocampal input to the hypothalamus is known to be critically involved in mediating the negative feedback inhibition of stress response. However, the underlying neural circuitry has not been fully elucidated. Using a combination of rabie…
View article: DNA methylation profiles in the blood of newborn term infants born to mothers with obesity
DNA methylation profiles in the blood of newborn term infants born to mothers with obesity Open
Maternal obesity is an important risk factor for childhood obesity and influences the prevalence of metabolic diseases in offspring. As childhood obesity is influenced by postnatal factors, it is critical to determine whether children born…
Non-nutritive bioactive components in maternal milk and offspring development: a scoping review Open
Lactation is a critical time in mammalian development, where maternal factors shape offspring outcomes. In this scoping review, we discuss current literature concerning maternal factors that influence lactation biology and highlight import…
Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care Open
The MT-RNR1 POCT was integrated without disrupting normal clinical practice, and genotype was used to guide antibiotic prescription and avoid AIO. This approach identified the m.1555A>G variant in a practice-changing time frame, and wide a…
Maternal BMI, breastfeeding and perinatal factors that influence early childhood growth trajectories: a scoping review Open
Obesity rates among children are rapidly rising internationally and have been linked to noncommunicable diseases in adulthood. Individual preventive strategies have not effectively reduced global obesity rates, leading to a gap in clinical…
Sex-specific maternal programming of corticosteroid-binding globulin by predator odour Open
Predation is a key organizing force in ecosystems. The threat of predation may act to programme the endocrine hypothalamic–pituitary–adrenal axis during development to prepare offspring for the environment they are likely to encounter. Suc…
Comparison of methods for pre-processing, exosome isolation, and RNA extraction in unpasteurized bovine and human milk Open
Milk is a highly complex, heterogeneous biological fluid that contains non-nutritive, bioactive extracellular vesicles called exosomes. Characterization of milk-derived exosomes (MDEs) is challenging due to the lack of standardized methods…
The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring Open
Introduction Rat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation. Methods We assessed early…
Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally—Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN): a Healthy Life Trajectories Initiative (HeLTI) Study Open
Introduction The Healthy Life Trajectories Initiative is an international consortium comprising four harmonised but independently powered trials to evaluate whether an integrated intervention starting preconceptionally will reduce non-comm…
Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups Open
Early life maternal care received has a profound effect on later-life behaviour in adult offspring, and previous studies have suggested epigenetic mechanisms are involved. Changes in thyroid hormone receptor signalling may be related to di…
Maternal high fat diet alters lactation-specific miRNA expression and programs the DNA methylome in the amygdala of female offspring Open
Adverse maternal diets high in saturated fats are associated with impaired neurodevelopment and epigenetic modifications in offspring. Maternal milk, the primary source of early life nutrition in mammals, contains lactation-specific microR…
Early-life Temperature Exposure Affects Thyroid Hormone Receptor Signaling and Epigenetic Regulation of the Paraventricular Nucleus in Female Rat Pups Open
Early-life maternal care received has a profound effect on later-life behaviour in adult offspring and previous studies have suggested epigenetic mechanisms (e.g., DNA methylation) are involved. Changes in thyroid hormone receptor signalin…
Supporting Datasets from Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups Open
Compiled Datasets for the Temperature, Maternal Care, qPCR, DNA methylation, and ChIP results.
Supporting Datasets from Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups Open
Compiled Datasets for the Temperature, Maternal Care, qPCR, DNA methylation, and ChIP results.
Dopamine Genotype Interacts with Inter-Individual Licking Received on Later-Life Licking Provisioning in Female Rat Offspring Open
In most mammals, mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that influences this propagation. We assessed early-life materna…
Developmental programming of the HPA axis and related behaviours: epigenetic mechanisms Open
It has been approximately 30 years since the seminal discoveries of David Barker and his colleagues, and research is beginning to unravel the mechanisms that underlie developmental programming. The early environment of the embryo, foetus a…
Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Open
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease of unknown etiology. Multiple studies point to disruptions in immune functioning in ME/CFS patients as well as specific genetic polymorphisms and alterations …
Maternal Predator Odor Exposure in Mice Programs Adult Offspring Social Behavior and Increases Stress-Induced Behaviors in Semi-Naturalistic and Commonly-Used Laboratory Tasks Open
Maternal stress has a profound impact on the long-term behavioral phenotype of offspring, including behavioral responses to stressful and social situations. In this study, we examined the effects of maternal exposure to predator odor, an e…
Additional file 20: of Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness Open
Table S15. Genes identified by both PePr and diffReps as having differential enrichment of H3K27ac in the frontal cortex of CORT + DFP exposed animals. (CSV 26Â kb)
Additional file 24: of Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness Open
Figure S7. Comparison of significantly enriched gene ontology biological process annotations in each of our analyses. UpSetR diagram [73] of Gene Ontology (GO) biological process (BP) annotations enriched in genes significant in each of ou…
Additional file 15: of Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness Open
Table S10. Gene Ontology (GO) Biological Process (BP) annotations found to be enriched in genes identified as uniquely differentially expressed in both the frontal cortex (Additional file 3: Table S1) and the hippocampus (Additional file 7…
Additional file 2: of Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness Open
Figure S2. Poisson dissimilarity matrix from frontal cortex RNA-seq. Heatmaps showing the Poisson dissimilarity matrix for our frontal cortex (B) RNA-seq samples. Darker blue indicates more similar samples. (CSV 2Â kb)
Additional file 4: of Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness Open
Figure S3. Frontal cortex RNA-seq significantly enriched KEGG pathway annotations. KEGG pathways significantly enriched in genes that were differentially expressed in the frontal cortex of CORT + DFP exposed mice. (CSV 6Â kb)