Patrick Oeckl
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View article: Targeting Cdc42 improves motor phenotype in Parkinson’s disease mice and reveals age-dependent susceptibility to α-synuclein
Targeting Cdc42 improves motor phenotype in Parkinson’s disease mice and reveals age-dependent susceptibility to α-synuclein Open
Aging and accumulation of α-synuclein (α-syn) oligomers in the brain are indisputably linked to Parkinson's disease (PD). Using an inducible α-syn oligomer mouse model, we demonstrate that the induction of PD-associated α-syn oligomers for…
View article: CSF Beta-Synuclein, SNAP-25, and Neurogranin in Infectious and Autoimmune Inflammatory Neurologic Diseases
CSF Beta-Synuclein, SNAP-25, and Neurogranin in Infectious and Autoimmune Inflammatory Neurologic Diseases Open
Elevated CSF levels of beta-syn, neurogranin, and NfL may suggest a common pattern of synaptic and neuroaxonal damage in both IINDs and AINDs. Although these biomarkers have limited value in distinguishing between different diseases, they …
View article: Molecular aging is the main driver of Parkinson’s Disease
Molecular aging is the main driver of Parkinson’s Disease Open
Aging as well as the presence of α-synuclein (α-syn) oligomers in the brain are indisputably linked to Parkinson’s disease (PD). A central concept of geroscience is that the biological processes of aging drive the onset of aging-associated…
View article: Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis
Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis Open
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 ( SOD1 )‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospina…
View article: Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia
Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia Open
Background Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD). Objective To investigate the diagnostic utility of the solub…
View article: Peptidomic analysis of CSF reveals new biomarker candidates for amyotrophic lateral sclerosis
Peptidomic analysis of CSF reveals new biomarker candidates for amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, and novel biomarkers are needed. We applied mass-spectrometry-based peptidomic analysis in cerebrospinal fluid (CSF) samples of ALS and non-neurodegenerative c…
View article: Most L1CAM Is not Associated with Extracellular Vesicles in Human Biofluids and iPSC–Derived Neurons
Most L1CAM Is not Associated with Extracellular Vesicles in Human Biofluids and iPSC–Derived Neurons Open
Transmembrane L1 cell adhesion molecule (L1CAM) is widely used as a marker to enrich for neuron-derived extracellular vesicles (EVs), especially in plasma. However, this approach lacks sufficient robust validation. This study aimed to asse…
View article: Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease
Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease Open
INTRODUCTION β‐synuclein is a promising blood marker to track synaptic degeneration in Alzheimer's disease (AD) but changes in preclinical AD are unclear. METHODS We investigated serum β‐synuclein in 69 cognitively unimpaired mutation non‐…
View article: TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models
TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models Open
Pathogenic mutations within the TBK1 gene leading to haploinsufficiency are causative of amyotrophic lateral sclerosis (ALS). This gene is linked to autophagy and inflammation, two cellular mechanisms reported to be dysregulated in ALS pat…
View article: Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer’s disease and behavioral-variant frontotemporal dementia
Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer’s disease and behavioral-variant frontotemporal dementia Open
Introduction The differentiation between Alzheimer’s disease (AD) and behavioral-variant frontotemporal dementia (bvFTD) can be complicated in the initial phase by shared symptoms and pathophysiological traits. Nevertheless, advancements i…
View article: Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation
Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation Open
Background We aimed to investigate the prognostic role of β‐synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS). …
View article: “RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS.”
“RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS.” Open
Recent research has demonstrated significant aberrant activation of the innate immune system in ALS model systems due to mutations in SOD1, TARDBP and C9orf72 through stimulation of the TBK1-IRF3 pathway. This pathway can be activated, for…
View article: Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC–derived neurons
Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC–derived neurons Open
Transmembrane L1 cell adhesion molecule (L1CAM) is widely used as a marker to enrich for neuron-derived extracellular vesicles (EVs), especially in plasma. However, this approach lacks sufficient robust validation. This study aimed to asse…
View article: Phosphorylated tau protein serum levels increase over time in patients with chronic heart failure
Phosphorylated tau protein serum levels increase over time in patients with chronic heart failure Open
Background/Introduction Amongst various potential biomarkers associated with cognitive deficits, phosphorylated Tau (pTau) appears to link brain and cardiac abnormalities through a systemic tauopathy pathway. Purpose A recent report on the…
View article: Contactin proteins in cerebrospinal fluid show different alterations in dementias
Contactin proteins in cerebrospinal fluid show different alterations in dementias Open
Background The proteins contactin (CNTN) 1–6 are synaptic proteins for which there is evidence that they are dysregulated in neurodegenerative dementias. Less is known about CNTN changes and differences in cerebrospinal fluid (CSF) of deme…
View article: Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration – A transdiagnostic study cross‐validating atrophy and fluid biomarkers
Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration – A transdiagnostic study cross‐validating atrophy and fluid biomarkers Open
INTRODUCTION Frontotemporal lobar degeneration (FTLD) encompasses behavioral variant frontotemporal dementia (bvFTD), progressive supranuclear palsy, corticobasal syndrome/degeneration, and primary progressive aphasias (PPAs). We cross‐val…
View article: Aquaporin-4 as an early cerebrospinal fluid biomarker of Alzheimer’s disease
Aquaporin-4 as an early cerebrospinal fluid biomarker of Alzheimer’s disease Open
Importance Aquaporin-4 (AQP4) plays a critical role in the glymphatic system, responsible for clearing brain solutes like Aβ peptides. Exploring AQP4 as an Alzheimer’s disease (AD) biomarker might aid in the understanding of AD neuropathol…
View article: Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1 Open
Background Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volume of the brain. Experimental models ha…
View article: Targeted proteomics upon Tofersen identifies candidate response markers for SOD1-linked amyotrophic lateral sclerosis
Targeted proteomics upon Tofersen identifies candidate response markers for SOD1-linked amyotrophic lateral sclerosis Open
Tofersen is the first effective and approved therapy for familial ALS caused by pathogenic variants in the SOD1 gene. Following treatment with tofersen, neurofilaments in patients CSF and serum display a faster response than clinical param…
View article: Incremental value of serum neurofilament light chain and glial fibrillary acidic protein as blood-based biomarkers for predicting functional outcome in severe acute ischemic stroke
Incremental value of serum neurofilament light chain and glial fibrillary acidic protein as blood-based biomarkers for predicting functional outcome in severe acute ischemic stroke Open
Introduction: Blood-based biomarkers may improve prediction of functional outcome in patients with acute ischemic stroke. The role of neurofilament light chain (NfL) and glial fibrillary acidic (GFAP) as potential biomarkers especially in …
View article: Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays Open
Objectives Increased levels of glial fibrillary acidic protein (GFAP) in blood have been identified as a valuable biomarker for some neurological disorders, such as Alzheimer’s disease and multiple sclerosis. However, most blood GFAP quant…
View article: Investigation of plasma β‐synuclein levels in different stages of Alzheimer´s disease and relation to amyloid and tau‐PET
Investigation of plasma β‐synuclein levels in different stages of Alzheimer´s disease and relation to amyloid and tau‐PET Open
Background Synaptic degeneration is a major hallmark of Alzheimer´s disease (AD). Easily accessible biomarkers are needed to study its role in AD pathogenesis and to detect positive effects on synaptic dysfunction in clinical drug trials. …
View article: High diagnostic performance of plasma and cerebrospinal fluid beta‐synuclein in the differential diagnosis of sporadic Creutzfeldt‐Jakob disease
High diagnostic performance of plasma and cerebrospinal fluid beta‐synuclein in the differential diagnosis of sporadic Creutzfeldt‐Jakob disease Open
Background Beta‐synuclein (beta‐syn) is an emerging biofluid marker for synaptic damage in several neurological diseases. In particular, patients with prion disease showed significantly higher cerebrospinal fluid (CSF) and blood beta‐syn l…
View article: The synaptic biomarker contactin5 differentiates between neurodegenerative dementias
The synaptic biomarker contactin5 differentiates between neurodegenerative dementias Open
Background Synapses are crucial for memory formation, and their disruption is among the earliest events in Alzheimer’s disease (AD) pathogenesis. Less is known about synaptic alterations in other types of dementia. Contactin5 (CNTN‐5) is a…
View article: Cerebrospinal fluid synaptic biomarkers in AT(N)‐based subgroups of Lewy body disease
Cerebrospinal fluid synaptic biomarkers in AT(N)‐based subgroups of Lewy body disease Open
Background Patients with Lewy body disease (LBD) often show a co‐occurring Alzheimer’s disease (AD) pathology. Cerebrospinal fluid (CSF) biomarkers allow the detection in vivo of AD‐related pathological hallmarks included in the AT(N) clas…