Patrick Plésiat
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View article: Adaptation to cinnamaldehyde shapes <i>Pseudomonas aeruginosa</i> resistance to major antibiotics
Adaptation to cinnamaldehyde shapes <i>Pseudomonas aeruginosa</i> resistance to major antibiotics Open
In France, the use of essential oils to treat bacterial infections is common, with approximately 40% of cystic fibrosis patients regularly using these natural products to control infections caused by Pseudomonas aeruginosa often in combina…
View article: Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model
Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model Open
Persistent bacterial infections evade host immunity and resist antibiotic treatments through various mechanisms that are difficult to evaluate in a living host. Pseudomonas aeruginosa is a main cause of chronic infections in patients with …
View article: Role of the two-component system AmgRS in early resistance of <i>Pseudomonas aeruginosa</i> to cinnamaldehyde
Role of the two-component system AmgRS in early resistance of <i>Pseudomonas aeruginosa</i> to cinnamaldehyde Open
Exposure of Pseudomonas aeruginosa to cinnamaldehyde (CNA), a natural electrophilic antimicrobial often used as self-medication to treat mild infections, triggers overproduction of the MexAB-OprM efflux system, leading to multidrug resista…
View article: Synthesis and antibacterial properties under blue LED light of conjugates between the siderophore desferrioxamine B (DFOB) and an Iridium(III) complex
Synthesis and antibacterial properties under blue LED light of conjugates between the siderophore desferrioxamine B (DFOB) and an Iridium(III) complex Open
View article: Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model
Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model Open
Persistent bacterial infections evade host immunity and resist antibiotic treatments through various mechanisms that are difficult to evaluate in a living host. Pseudomonas aeruginosa is a main cause of chronic infections in patients with …
View article: 2‐Thiophenyl–Isoquinoline Ir(III) Complex: A Promising Tool in Antipseudomonal Photodynamic Therapy under Red Irradiation
2‐Thiophenyl–Isoquinoline Ir(III) Complex: A Promising Tool in Antipseudomonal Photodynamic Therapy under Red Irradiation Open
Innovative therapeutic strategies are more than ever needed to counter the rise of antibiotic–resistant bacterial pathogens worldwide. The use of light, and especially photodynamic therapy (PDT) appears as a promising alternative or comple…
View article: Mutations in genes <i>lpxL1</i> , <i>bamA</i> , and <i>pmrB</i> impair the susceptibility of cystic fibrosis strains of <i>Pseudomonas aeruginosa</i> to murepavadin
Mutations in genes <i>lpxL1</i> , <i>bamA</i> , and <i>pmrB</i> impair the susceptibility of cystic fibrosis strains of <i>Pseudomonas aeruginosa</i> to murepavadin Open
Murepavadin is a peptidomimetic exhibiting specific inhibitory activity against Pseudomonas species. In the present study, its in vitro activity was assessed on 230 cystic fibrosis (CF) strains of Pseudomonas aeruginosa isolated from 12 Fr…
View article: Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades
Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades Open
View article: Mutations in genes<i>lpxL1, bamA</i>and<i>pmrB</i>impair the susceptibility of cystic fibrosis strains of<i>Pseudomonas aeruginosa</i>to murepavadin
Mutations in genes<i>lpxL1, bamA</i>and<i>pmrB</i>impair the susceptibility of cystic fibrosis strains of<i>Pseudomonas aeruginosa</i>to murepavadin Open
Murepavadin is a peptidomimetic exhibiting specific inhibitory activity against Pseudomonas species. In the present study, its in vitro activity was assessed on 230 cystic fibrosis (CF) strains of P. aeruginosa isolated from twelve French …
View article: Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9
Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9 Open
Here, we characterized the first French NDM-9-producing Acinetobacter baumannii isolate. A. baumannii 13A297, which belonged to the ST Pas 25 (international clone IC7), was highly resistant to β-lactams including cefiderocol (MIC >32 mg…
View article: WS07.02 Zebrafish infection model to assess persistence of Pseudomonas aeruginosa clinical isolates and treatment efficiency
WS07.02 Zebrafish infection model to assess persistence of Pseudomonas aeruginosa clinical isolates and treatment efficiency Open
View article: Performance of discs, sensititre EUMDROXF microplates and MTS gradient strips for the determination of the susceptibility of multidrug-resistant Pseudomonas aeruginosa to cefiderocol
Performance of discs, sensititre EUMDROXF microplates and MTS gradient strips for the determination of the susceptibility of multidrug-resistant Pseudomonas aeruginosa to cefiderocol Open
International audience
View article: Exposure of Pseudomonas aeruginosa to Cinnamaldehyde Selects Multidrug Resistant Mutants
Exposure of Pseudomonas aeruginosa to Cinnamaldehyde Selects Multidrug Resistant Mutants Open
Cinnamaldehyde (CNA), the main component of cinnamon essential oil, is one of the most active plant compounds against nosocomial pathogen Pseudomonas aeruginosa. Exposure of wild-type strain PA14 (MIC 700 µg/mL) for 5 to 10 days to fixed (…
View article: IgA Serological Response for the Diagnosis of Mycobacterium abscessus Infections in Patients with Cystic Fibrosis
IgA Serological Response for the Diagnosis of Mycobacterium abscessus Infections in Patients with Cystic Fibrosis Open
Mycobacterium abscessus is currently the most frequently isolated rapid growing mycobacterium in human pathology and the major one involved in lung infections. It has recently emerged as responsible for severe pulmonary infections in patie…
View article: Detection of Colistin Resistance in Pseudomonas aeruginosa Using the MALDIxin Test on the Routine MALDI Biotyper Sirius Mass Spectrometer
Detection of Colistin Resistance in Pseudomonas aeruginosa Using the MALDIxin Test on the Routine MALDI Biotyper Sirius Mass Spectrometer Open
Colistin is frequently a last resort treatment for Pseudomonas aeruginosa infections caused by multidrug-resistant (MDR) and extensively drug resistant (XDR) strains, and detection of colistin resistance is essential for the management of …
View article: Molecular and epidemiological investigation of a colistin-resistant OXA-23-/NDM-1-producing Acinetobacter baumannii outbreak in the Southwest Indian Ocean Area
Molecular and epidemiological investigation of a colistin-resistant OXA-23-/NDM-1-producing Acinetobacter baumannii outbreak in the Southwest Indian Ocean Area Open
View article: Negative Impact of Citral on Susceptibility of Pseudomonas aeruginosa to Antibiotics
Negative Impact of Citral on Susceptibility of Pseudomonas aeruginosa to Antibiotics Open
Essential oils (EOs) or their components are widely used by inhalation or nebulization to fight mild respiratory bacterial infections. However, their interaction with antibiotics is poorly known. In this study we evaluated the effects of c…
View article: Performance of disc diffusion, MIC gradient tests and Vitek 2 for ceftolozane/tazobactam and ceftazidime/avibactam susceptibility testing of<i>Pseudomonas aeruginosa</i>
Performance of disc diffusion, MIC gradient tests and Vitek 2 for ceftolozane/tazobactam and ceftazidime/avibactam susceptibility testing of<i>Pseudomonas aeruginosa</i> Open
Objectives To assess performance of disc diffusion, gradient tests and Vitek 2 system to determine the susceptibility of clinical Pseudomonas aeruginosa strains to ceftolozane/tazobactam (C/T) and ceftazidime/avibactam (CZA). Methods Two-h…
View article: Targeted Genome Reduction of Pseudomonas aeruginosa Strain PAO1 Led to the Development of Hypovirulent and Hypersusceptible rDNA Hosts
Targeted Genome Reduction of Pseudomonas aeruginosa Strain PAO1 Led to the Development of Hypovirulent and Hypersusceptible rDNA Hosts Open
Pseudomonas aeruginosa is a human opportunistic pathogen responsible for nosocomial infections, which is largely used as a model organism to study antibiotic resistance and pathogenesis. As other species of the genus, its wide metabolic ve…
View article: P146 Intra-patient evolution of a pulmonary strain of Pseudomonas aeruginosa, from primocolonisation to lung transplant
P146 Intra-patient evolution of a pulmonary strain of Pseudomonas aeruginosa, from primocolonisation to lung transplant Open
View article: Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa: Results of the GERPA Multicenter Study
Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa: Results of the GERPA Multicenter Study Open
Resistance mechanisms of Pseudomonas aeruginosa to ceftolozane/tazobactam (C/T) were assessed on a collection of 420 nonredundant strains nonsusceptible to ceftazidime (MIC > 8 μg/ml) and/or imipenem (>4 μg/ml), collected by 36 French hosp…
View article: Involvement of the <i>Pseudomonas aeruginosa</i> MexAB–OprM efflux pump in the secretion of the metallophore pseudopaline
Involvement of the <i>Pseudomonas aeruginosa</i> MexAB–OprM efflux pump in the secretion of the metallophore pseudopaline Open
To overcome the metal restriction imposed by the host’s nutritional immunity, pathogenic bacteria use high metal affinity molecules called metallophores. Metallophore‐mediated metal uptake pathways necessitate complex cycles of synthesis, …
View article: Involvement of the<i>Pseudomonas aeruginosa</i>MexAB-OprM efflux pump in the secretion of the metallophore pseudopaline
Involvement of the<i>Pseudomonas aeruginosa</i>MexAB-OprM efflux pump in the secretion of the metallophore pseudopaline Open
The ability for all organisms to acquire metals from their environment is essential for life. To overcome the metal restriction imposed by the host’s nutritional immunity, bacterial pathogens exploits the use of small high metal affinity m…
View article: Development of a database for the rapid and accurate routine identification of Achromobacter species by matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS)
Development of a database for the rapid and accurate routine identification of Achromobacter species by matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS) Open
View article: The Efflux Pump MexXY/OprM Contributes to the Tolerance and Acquired Resistance of Pseudomonas aeruginosa to Colistin
The Efflux Pump MexXY/OprM Contributes to the Tolerance and Acquired Resistance of Pseudomonas aeruginosa to Colistin Open
The intrinsic resistance of Pseudomonas aeruginosa to polymyxins in part relies on the addition of 4-amino-4-deoxy- l -arabinose (Ara4N) molecules to the lipid A of lipopolysaccharide (LPS), through induction of operon arnBCADTEF-ugd ( arn…
View article: A Standard Numbering Scheme for Class C β-Lactamases
A Standard Numbering Scheme for Class C β-Lactamases Open
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative app…
View article: The Transcriptional Repressor SmvR Is Important for Decreased Chlorhexidine Susceptibility in Enterobacter cloacae Complex
The Transcriptional Repressor SmvR Is Important for Decreased Chlorhexidine Susceptibility in Enterobacter cloacae Complex Open
Major facilitator superfamily (MFS) efflux pumps have been shown to be important for bacterial cells to cope with biocides such as chlorhexidine (CHX), a widely used molecule in hospital settings. In this work, we evaluated the role of two…
View article: Étude de la production de biofilm, de la résistance aux antibiotiques et aux biocides chez des souches de Pseudomonas aeruginosa isolées chez l'Homme et l'animal.
Étude de la production de biofilm, de la résistance aux antibiotiques et aux biocides chez des souches de Pseudomonas aeruginosa isolées chez l'Homme et l'animal. Open
View article: Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa
Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa Open
Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor th…
View article: Production of Norspermidine Contributes to Aminoglycoside Resistance in <i>pmrAB</i> Mutants of Pseudomonas aeruginosa
Production of Norspermidine Contributes to Aminoglycoside Resistance in <i>pmrAB</i> Mutants of Pseudomonas aeruginosa Open
Emergence of resistance to polymyxins in Pseudomonas aeruginosa is mainly due to mutations in two-component systems that promote the addition of 4-amino-4-deoxy- l -arabinose to the lipopolysaccharide (LPS) through upregulation of operon a…