Patrick R. Punch
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View article: Extracellular ST6GAL1 regulates monocyte–macrophage development and survival
Extracellular ST6GAL1 regulates monocyte–macrophage development and survival Open
Interaction of immune cells with the systemic environment is necessary for the coordinated development and execution of immune responses. Monocyte-macrophage lineage cells reside at the junction of innate and adaptive immunity. Previously …
View article: Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells
Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells Open
Humoral immunity is an effective but metabolically expensive defense mechanism. It is unclear whether systemic cues exist to communicate the dynamic need for antigen presentation and immunoglobulin production. Here, we report a novel role …
View article: The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage
The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage Open
High-dose irradiation poses extreme risk of mortality from acute damage to the hematopoietic compartment and gastrointestinal tract. While bone marrow transplantation can reestablish the hematopoietic compartment, a more imminent risk of d…
View article: Extrinsic sialylation is dynamically regulated by systemic triggers in vivo
Extrinsic sialylation is dynamically regulated by systemic triggers in vivo Open
Recent reports have documented that extracellular sialyltransferases can remodel both cell-surface and secreted glycans by a process other than the canonical cell-autonomous glycosylation that occurs within the intracellular secretory appa…