Patrick R. Stoddard
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View article: Polymerization in the actin ATPase clan regulates hexokinase activity in yeast
Polymerization in the actin ATPase clan regulates hexokinase activity in yeast Open
Polymerization regulates hexokinase activity The yeast hexokinase Glk1 is an actin-fold protein that forms polymers in response to binding its substrates and products. Stoddard et al. now show that Glk1 polymers are structurally distinct f…
View article: Glucokinase Polymerization Regulates Enzyme Activity in Response to Environmental Shifts
Glucokinase Polymerization Regulates Enzyme Activity in Response to Environmental Shifts Open
Unlike cells in a multicellular organism, free living microbes are subject to abrupt changes in environment that can come with no warning. Cells must be prepared to react to these changes on timescales too short for them to change their co…
View article: Independent evolution of polymerization in the Actin ATPase clan regulates hexokinase activity
Independent evolution of polymerization in the Actin ATPase clan regulates hexokinase activity Open
The actin protein fold is found in cytoskeletal polymers, chaperones, and various metabolic enzymes. Many actin-fold proteins, like the carbohydrate kinases, do not polymerize. We find that Glk1, a Saccharomyces cerevisiae glucokinase, for…
View article: Evolution of polymer formation within the actin superfamily
Evolution of polymer formation within the actin superfamily Open
While many are familiar with actin as a well-conserved component of the eukaryotic cytoskeleton, it is less often appreciated that actin is a member of a large superfamily of structurally related protein families found throughout the tree …