Patrick Rabe
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View article: Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressing <i>Mycobacterium smegmatis</i>
Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressing <i>Mycobacterium smegmatis</i> Open
β-lactams demonstrate promising in vitro activity against Mycobacterium species and are being explored for tuberculosis treatment; however, evidence of their in vivo efficacy versus Mycobacterium tuberculosis remains limited. To achieve br…
View article: Filamin C dimerisation is regulated by HSPB7
Filamin C dimerisation is regulated by HSPB7 Open
The biomechanical properties and responses of tissues underpin a variety important of physiological functions and pathologies. In striated muscle, the actin-binding protein filamin C (FLNC) is a key protein whose variants causative for a w…
View article: Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate
Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate Open
The essential l,d -transpeptidase of Mycobacterium tuberculosis (Ldt Mt2 ) catalyses the formation of 3 $$\to$$ 3 cross-links in cell wall peptidoglycan and is a target for development of antituberculosis therapeutics. Efforts to inhibit…
View article: Cardiac stress leads to regulation of Filamin C dimerisation via an ancient phosphorylation-modulated interaction with HSPB7
Cardiac stress leads to regulation of Filamin C dimerisation via an ancient phosphorylation-modulated interaction with HSPB7 Open
The biomechanical properties and responses of tissues underpin a variety of physiological functions and pathologies. In striated muscle, the actin-binding protein filamin C (FLNC) is a key protein whose variants causative for a wide range …
View article: Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products
Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products Open
L1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyzes most β-lactam antibiotics and is a key resistance determinant in the Gram-negative pathogen Stenotrophomonas maltophilia, an important cause of nosocomial infections in i…
View article: CCDC 2175925: Experimental Crystal Structure Determination
CCDC 2175925: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2175923: Experimental Crystal Structure Determination
CCDC 2175923: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2175924: Experimental Crystal Structure Determination
CCDC 2175924: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2176171: Experimental Crystal Structure Determination
CCDC 2176171: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2175926: Experimental Crystal Structure Determination
CCDC 2175926: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase Open
Isopenicillin N synthase (IPNS) catalyzes formation of the β-lactam and thiazolidine rings of isopenicillin N from its linear tripeptide l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) substrate in an iron- and dioxygen (O2)-dependent four…
View article: Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane Open
Small-ring cage hydrocarbons are common bioisosteres for para-substituted benzene rings in drug design, exhibiting superior pharmacokinetic properties compared to the parent aromatics. In contrast, scaffolds mimicking meta-substituted aren…
View article: Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors Open
Significance Microbial resistance to β-lactam antibiotics mediated by β-lactamase–catalyzed hydrolysis is a major global health concern. Penam sulfones, which are structurally related to penicillins, inhibit clinically important serine β-l…
View article: Correction to “Structural Basis of Metallo-β-lactamase Inhibition by <i>N</i>-Sulfamoylpyrrole-2-carboxylates”
Correction to “Structural Basis of Metallo-β-lactamase Inhibition by <i>N</i>-Sulfamoylpyrrole-2-carboxylates” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates"Alistair J. M. FarleyAlistair J. M. F…
View article: X-ray free-electron laser studies reveal correlated motion during isopenicillin <i>N</i> synthase catalysis
X-ray free-electron laser studies reveal correlated motion during isopenicillin <i>N</i> synthase catalysis Open
Complementary XFEL methods reveal O 2 reaction intermediates and global protein dynamics during Isopenicillin N synthase catalysis.
View article: The Termite Fungal Cultivar <i>Termitomyces</i> Combines Diverse Enzymes and Oxidative Reactions for Plant Biomass Conversion
The Termite Fungal Cultivar <i>Termitomyces</i> Combines Diverse Enzymes and Oxidative Reactions for Plant Biomass Conversion Open
Fungus-growing termites have optimized the decomposition of recalcitrant plant biomass to access valuable nutrients by engaging in a tripartite symbiosis with complementary contributions from a fungal mutualist and a codiversified gut micr…
View article: Structural Basis of Metallo-β-lactamase Inhibition by<i>N</i>-Sulfamoylpyrrole-2-carboxylates
Structural Basis of Metallo-β-lactamase Inhibition by<i>N</i>-Sulfamoylpyrrole-2-carboxylates Open
Metallo-β-lactamases (MBLs) can efficiently catalyze the hydrolysis of all classes of β-lactam antibiotics except monobactams. While serine-β-lactamase (SBL) inhibitors (e.g., clavulanic acid, avibactam) are established for clinical use, n…
View article: The termite fungal cultivar<i>Termitomyces</i>combines diverse enzymes and oxidative reactions for plant biomass conversion
The termite fungal cultivar<i>Termitomyces</i>combines diverse enzymes and oxidative reactions for plant biomass conversion Open
Macrotermitine termites have domesticated fungi in the genus Termitomyces as their primary food source using pre-digested plant biomass. To access the full nutritional value of lignin-enriched plant biomass, the termite-fungus symbiosis re…
View article: Anaerobic fixed-target serial crystallography
Anaerobic fixed-target serial crystallography Open
Cryogenic X-ray diffraction is a powerful tool for crystallographic studies on enzymes including oxygenases and oxidases. Amongst the benefits that cryo-conditions (usually employing a nitrogen cryo-stream at 100 K) enable, is data collect…
View article: A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene
A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene Open
Terpenoids are enormously diverse, but our knowledge of their biosynthesis and functions is limited. Here we report on a terpene synthase (DdTPS8)-cytochrome P450 (CYP521A1) gene cluster that produces a novel C12 trisnorsesquiterpene and a…
View article: Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis Open
The 2OG oxygenases and IPNS contribute to the great structural diversity of β-lactam natural products, employing some remarkable mechanisms.