Patrick Reich
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View article: P-486. Implementation of a Proactive and Standardized Approach to Isolation Discontinuation and Survey of Outcomes (IP-SAID-SO)
P-486. Implementation of a Proactive and Standardized Approach to Isolation Discontinuation and Survey of Outcomes (IP-SAID-SO) Open
Background Isolation precautions protect healthcare workers (HCWs) and patients, but can have significant environmental impacts, high cost, and be a barrier to patient safety and satisfaction. Respiratory viral infections are the most comm…
View article: P-1139. Leveraging Instant Orders to Create a Semi-Automated Process for Candida auris Ring Surveillance
P-1139. Leveraging Instant Orders to Create a Semi-Automated Process for Candida auris Ring Surveillance Open
Background Candida auris is a growing threat among healthcare-associated infections due to its resistance to several antifungal classes and potential for spread within healthcare settings. Ring surveillance involves polymerase chain reacti…
View article: Hospital-onset bacteremia in the neonatal intensive care unit: strategies for risk adjustment
Hospital-onset bacteremia in the neonatal intensive care unit: strategies for risk adjustment Open
Objective: To quantify the impact of patient- and unit-level risk adjustment on infant hospital-onset bacteremia (HOB) standardized infection ratio (SIR) ranking. Design: A retrospective, multicenter cohort study. Setting and participants:…
View article: P-700. Examining the Knowledge, Availability, Access and Uptake of RSV Immunoprophylasis among RSV Hospitalized Infants
P-700. Examining the Knowledge, Availability, Access and Uptake of RSV Immunoprophylasis among RSV Hospitalized Infants Open
Background Every year, up to 80,000 children less than 5 years are hospitalized due to RSV infection and those less than 1 are at greatest risk for ICU admission. In the Fall of 2023, 2 immunoprophylaxis strategies, nirsevimab for infants …
View article: P-1201. Impact of Demographic Factors and Social Determinants of Health on RSV Immunoprophylaxis in Infants
P-1201. Impact of Demographic Factors and Social Determinants of Health on RSV Immunoprophylaxis in Infants Open
Background In 2023, two highly effective forms of respiratory syncytial virus (RSV) immunoprophylaxis to prevent severe RSV disease in young children were approved: Abrysvo (vaccine in pregnancy) and nirsevimab (infant monoclonal antibody)…
View article: P-1182. Impact of Standard Infection Prevention Measures, Including Contact Precautions, on <i>Serratia marcescens</i> Outbreaks in the Neonatal ICU
P-1182. Impact of Standard Infection Prevention Measures, Including Contact Precautions, on <i>Serratia marcescens</i> Outbreaks in the Neonatal ICU Open
Background Serratia marcescens outbreaks attributed to lapses in hand hygiene, contaminated sinks or drains, and other sources of environmental contamination have been observed in the neonatal intensive care unit (NICU).1S. marcescens outb…
View article: Lessons Learned from a Quality Improvement Initiative to Increase COVID-19 Vaccination in Hospitalized Children
Lessons Learned from a Quality Improvement Initiative to Increase COVID-19 Vaccination in Hospitalized Children Open
Introduction: Pediatric coronavirus disease 2019 (COVID-19) vaccination rates in the United States remain lower compared with adults. We aimed to (1) implement a quality improvement initiative to increase COVID-19 vaccination 2-fold in hos…
View article: S. aureus Surveillance and Decolonization Associated with Decreased MRSA, but not MSSA, Infections in the Neonatal ICU
S. aureus Surveillance and Decolonization Associated with Decreased MRSA, but not MSSA, Infections in the Neonatal ICU Open
Background: Invasive Staphylococcus aureus infections cause significant morbidity and mortality in neonatal intensive care unit (NICU) infants.1 Colonization (asymptomatic carriage in the nose, skin, or gut) is a risk factor for subsequent…
View article: Hospital-Onset Bacteremia Among Neonatal Intensive Care Unit Patients
Hospital-Onset Bacteremia Among Neonatal Intensive Care Unit Patients Open
Importance The Centers for Disease Control and Prevention plans to introduce hospital-onset bacteremia (HOB) as a health care–associated infection measure. The epidemiology and clinical characteristics of HOB among infants admitted to the …
View article: ICE volume 44 issue 12 Cover and Front matter
ICE volume 44 issue 12 Cover and Front matter Open
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View article: Invasive Community-Onset Gram-Positive Infections From July 2018 Through December 2022 at 2 Children's Hospitals
Invasive Community-Onset Gram-Positive Infections From July 2018 Through December 2022 at 2 Children's Hospitals Open
Background Invasive infections caused by Streptococcus pyogenes (invasive group A streptococcus [iGAS]) and Streptococcus pneumoniae (invasive pneumococcal disease [IPD]) decreased substantially at the beginning of the COVID-19 pandemic. O…
View article: Healthcare worker perceptions surrounding <i>Staphylococcus aureus</i> transmission and prevention practices in the neonatal intensive care unit
Healthcare worker perceptions surrounding <i>Staphylococcus aureus</i> transmission and prevention practices in the neonatal intensive care unit Open
Objective: To understand healthcare worker (HCW) perceptions surrounding Staphylococcus aureus transmission and prevention in the neonatal intensive care unit (NICU). Design: Qualitative case study with focus groups. Setting: A level IV, 1…
View article: Mortality in pediatric oncology and stem cell transplant patients with bloodstream infections
Mortality in pediatric oncology and stem cell transplant patients with bloodstream infections Open
Background Bloodstream infections (BSI) continue to represent a significant source of morbidity for pediatric oncology patients, however less is known regarding this population’s risk of death. We sought to evaluate the risk of BSI and dea…
View article: 2315. Impact of MSSA Surveillance and Decolonization on Invasive Infection in the Neonatal ICU
2315. Impact of MSSA Surveillance and Decolonization on Invasive Infection in the Neonatal ICU Open
Background Invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections are an important cause of morbidity and mortality in neonatal intensive care unit (NICU) infants. MSSA colonization (asymptomatic carriage in the nose, ski…
View article: Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit
Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit Open
In this study, we found a high prevalence of Staphylococcus aureus isolates exhibiting a borderline oxacillin resistance phenotype (BORSA) in our neonatal intensive care unit (NICU) serendipitously due to the type of MRSA screening agar us…
View article: Association between Endocrine Disorders and Severe COVID-19 Disease in Pediatric Patients
Association between Endocrine Disorders and Severe COVID-19 Disease in Pediatric Patients Open
Introduction: Though severe illness due to COVID-19 is uncommon in children, there is an urgent need to better determine the risk factors for disease severity in youth. This study aims to determine the impact a preexisting endocrine diagno…
View article: Implications of Oxacillin-Resistant, <i>mecA</i>-Negative <i>Staphylococcus aureus</i> Detected in NICU MRSA Surveillance Cultures
Implications of Oxacillin-Resistant, <i>mecA</i>-Negative <i>Staphylococcus aureus</i> Detected in NICU MRSA Surveillance Cultures Open
Background: Weekly surveillance to identify neonatal intensive care unit (NICU) infants with methicillin-resistant S. aureus (MRSA) nasal colonization was performed using Remel Spectra MRSA chromogenic media. An increased MRSA colonization…
View article: Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed
Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed Open
Background: Although significant disease burden in the severe acute respiratory syndrome coronavirus 2 pandemic has been relatively uncommon in children, worldwide cases of a postinfectious multisystem inflammatory syndrome in children and…
View article: 589. Impact of Parents and the Environment on MRSA Transmission in the Neonatal ICU
589. Impact of Parents and the Environment on MRSA Transmission in the Neonatal ICU Open
Background Methicillin-resistant Staphylococcus aureus (MRSA) colonization predisposes Neonatal Intensive Care Unit (NICU) infants to subsequent infection. Reservoirs for acquisition remain poorly understood, limiting infection prevention …
View article: Carriage of the Toxic Shock Syndrome Toxin Gene by Contemporary Community-Associated Staphylococcus aureus Isolates
Carriage of the Toxic Shock Syndrome Toxin Gene by Contemporary Community-Associated Staphylococcus aureus Isolates Open
We report here the prevalence of the tst-1 gene among 252 methicillin-susceptible Staphylococcus aureus (MSSA) isolates and 458 methicillin-resistant S aureus (MRSA) isolates collected from 531 subjects between 2008 and 2017, one of which …
View article: Saksenaea vasiformis Orbital Cellulitis in an Immunocompetent Child Treated With Posaconazole
Saksenaea vasiformis Orbital Cellulitis in an Immunocompetent Child Treated With Posaconazole Open
An 11-year-old immunocompetent girl presented with two and a half months of progressive right orbital cellulitis, which did not respond to multiple courses of antibiotics or prednisone. A panfungal polymerase chain reaction primer was posi…
View article: Familial and Environmental Impact on Colonization with Antibiotic-resistant Organisms in the Neonatal Intensive Care Unit
Familial and Environmental Impact on Colonization with Antibiotic-resistant Organisms in the Neonatal Intensive Care Unit Open
Colonization with antibiotic-resistant organisms (AROs), including methicillin-resistant S. aureus (MRSA), places neonatal intensive care unit (NICU) patients at increased risk for infection. Infants are routinely screened for MRSA coloniz…
View article: Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome
Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome Open
Pneumococcal-associated hemolytic uremic syndrome (pHUS) is a rare but severe complication of invasive Streptococcus pneumoniae infection. We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with ad…