Patrick Rollin
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View article: α-Cyclodextrin/Moringin Impacts Actin Cytoskeleton Dynamics with Potential Implications for Synaptic Organization: A Preliminary Transcriptomic Study in NSC-34 Motor Neurons
α-Cyclodextrin/Moringin Impacts Actin Cytoskeleton Dynamics with Potential Implications for Synaptic Organization: A Preliminary Transcriptomic Study in NSC-34 Motor Neurons Open
α-Cyclodextrin/Moringin (α-CD/MOR) is an isothiocyanate showing neuroprotective and antioxidant properties. In this work, we studied in differentiated NSC-34 motor neurons cell line the molecular pathways activated following a treatment of…
View article: Synthesis of ω-Methylsulfinyl- and ω-Methylsulfonylalkyl Glucosinolates
Synthesis of ω-Methylsulfinyl- and ω-Methylsulfonylalkyl Glucosinolates Open
General pathways were devised to synthesize ω-methylsulfinyl- and ω-methylsulfonylalkyl glucosinolates, which represent an important class of structurally homogeneous plant specialized metabolites. The first approach was based on the selec…
View article: A new synthetic approach to the 3,4-dihydro-1<i>H</i>-[1,4]oxazino[4,3-<i>a</i>]indole system from ethyl 1<i>H</i>-indole-2-carboxylates and activated glycerol carbonate
A new synthetic approach to the 3,4-dihydro-1<i>H</i>-[1,4]oxazino[4,3-<i>a</i>]indole system from ethyl 1<i>H</i>-indole-2-carboxylates and activated glycerol carbonate Open
An efficient synthesis of a small library of potentially bioactive 3,4-dihydro-1 H -[1,4]oxazino[4,3- a ]indoles is described through the reaction of ethyl 1 H -indole-2-carboxylates and activated glycerol carbonate.
View article: Cardio- and neuroprotective effects by pretreatment of dietary moringin from <i>Moringa oleifera</i> seeds and α-CD/moringin formulation in a rat model of isoproterenol-induced myocardial infarction
Cardio- and neuroprotective effects by pretreatment of dietary moringin from <i>Moringa oleifera</i> seeds and α-CD/moringin formulation in a rat model of isoproterenol-induced myocardial infarction Open
The aim of this study was to investigate the cardio- and neuroprotective effects of moringin (MG), a dietary isothiocyanate readily derived from Moringa oleifera seed, in a rat model of isoproterenol (ISP) induced myocardial infarction (MI…
View article: Cultivated Winter-Type Lunaria annua L. Seed: Deciphering the Glucosinolate Profile Integrating HPLC, LC-MS and GC-MS Analyses, and Determination of Fatty Acid Composition
Cultivated Winter-Type Lunaria annua L. Seed: Deciphering the Glucosinolate Profile Integrating HPLC, LC-MS and GC-MS Analyses, and Determination of Fatty Acid Composition Open
Lunaria annua L. (Brassicaceae) is an ornamental plant newly identified in Europe as a promising industrial oilseed crop for its valuable very-long-chain monounsaturated fatty acids (MUFAs), especially erucic acid (EA) and nervonic acid (N…
View article: α-Cyclodextrin/Moringin Induces an Antioxidant Transcriptional Response Activating Nrf2 in Differentiated NSC-34 Motor Neurons
α-Cyclodextrin/Moringin Induces an Antioxidant Transcriptional Response Activating Nrf2 in Differentiated NSC-34 Motor Neurons Open
Oxidative stress is a common feature of neurodegenerative diseases. Different natural compounds mediate neuroprotective effects by activating the Nrf2 antioxidant response. Some isothiocyanates are Nrf2 activators, including Moringin (MOR)…
View article: Glucosinolates in non-Brassicales plant species: Critical literature evaluation and testing of two high chemical quality reports
Glucosinolates in non-Brassicales plant species: Critical literature evaluation and testing of two high chemical quality reports Open
Glucosinolates (GSLs) are secondary metabolites mainly found in the plant order Brassicales. We critically evaluate reports of GSLs in other orders of flowering plants, propose standards for future reports and subject two cases to rigorous…
View article: Synthetic Modifications of Andrographolide Targeting New Potential Anticancer Drug Candidates: A Comprehensive Overview
Synthetic Modifications of Andrographolide Targeting New Potential Anticancer Drug Candidates: A Comprehensive Overview Open
This review collects the synthetic modifications performed on andrographolide, a natural molecule derived from Andrographis paniculata, for oncology applications. Various pharmacomodulations were carried out, and the products were tested o…
View article: Antiallergic Effect of the Alpha‐Cyclodextrin Moringin Complex in Rat Basophilic Leukaemia (RBL‐2H3) Cell Line
Antiallergic Effect of the Alpha‐Cyclodextrin Moringin Complex in Rat Basophilic Leukaemia (RBL‐2H3) Cell Line Open
Allergic diseases (ADs) are a major concern when it comes to public well‐being. Moringa oleifera Lam is a tropical plant that is used in traditional medicine due to the presence of isothiocyanate. The present study investigated the antiall…
View article: Glycerol‐1,2‐carbonate: <scp>A</scp> mild reagent for the <i>N</i>‐glycerylation of pyrazolecarboxylates
Glycerol‐1,2‐carbonate: <span>A</span> mild reagent for the <i>N</i>‐glycerylation of pyrazolecarboxylates Open
In this study, glycerol‐1,2‐carbonate was employed as a convenient reagent for the synthesis of more complex pyrazole‐containing heterocyclic systems. 3‐ O ‐Tosylated glycerol‐1,2‐carbonate (TGC) was used for alkylation of NH‐pyrazolecarbo…
View article: Monoterpene Thiols: Synthesis and Modifications for Obtaining Biologically Active Substances
Monoterpene Thiols: Synthesis and Modifications for Obtaining Biologically Active Substances Open
Monoterpene thiols are one of the classes of natural flavors that impart the smell of citrus fruits, grape must and wine, black currants, and guava and are used as flavoring agents in the food and perfume industries. Synthetic monoterpene …
View article: Glucosinolates and Cytotoxic Activity of Collard Volatiles Obtained Using Microwave-Assisted Extraction
Glucosinolates and Cytotoxic Activity of Collard Volatiles Obtained Using Microwave-Assisted Extraction Open
Glucosinolates (GSLs) in Brassica oleracea L. convar. acephala var. viridis (collard) flower, leaf, stem, and root were analyzed qualitatively and quantitatively via their desulfo-counterparts using UHPLC-DAD-MS/MS. Twelve GSLs were identi…
View article: Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases
Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases Open
Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that affect the nervous system and heart, all of which are vital to the human body. To maintain health of the human body, vegetable diets serve as a prevent…
View article: Mild Copper-Catalyzed, l-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate
Mild Copper-Catalyzed, l-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate Open
Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon–nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of (hetero)aryl iodides usi…
View article: Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates
Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates Open
Glucosinolates (GSLs) from Lepidium graminifolium L. were analyzed qualitatively and quantitatively by their desulfo-counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products-isothiocyanates (ITCs) using GC-MS a…
View article: Five-Membered Cyclic Carbonates: Versatility for Applications in Organic Synthesis, Pharmaceutical, and Materials Sciences
Five-Membered Cyclic Carbonates: Versatility for Applications in Organic Synthesis, Pharmaceutical, and Materials Sciences Open
This review presents the recent advances involving several applications of five-membered cyclic carbonates and derivatives. With more than 150 references, it covers the period from 2012 to 2020, with special emphasis on the use of five-mem…
View article: The Moringin/α-CD Pretreatment Induces Neuroprotection in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study
The Moringin/α-CD Pretreatment Induces Neuroprotection in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and represents the most common form of senile dementia. Autophagy and mitophagy are cellular processes that play a key role in the aggregation of β-amyloid (Aβ) and tau p…
View article: Application of Google Earth Engine Cloud Computing Platform, Sentinel Imagery, and Neural Networks for Crop Mapping in Canada
Application of Google Earth Engine Cloud Computing Platform, Sentinel Imagery, and Neural Networks for Crop Mapping in Canada Open
The ability of the Canadian agriculture sector to make better decisions and manage its operations more competitively in the long term is only as good as the information available to inform decision-making. At all levels of Government, a re…
View article: CCDC 1979887: Experimental Crystal Structure Determination
CCDC 1979887: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Microwave-Assisted versus Conventional Isolation of Glucosinolate Degradation Products from Lunaria annua L. and Their Cytotoxic Activity
Microwave-Assisted versus Conventional Isolation of Glucosinolate Degradation Products from Lunaria annua L. and Their Cytotoxic Activity Open
Glucosinolates (GSLs) from Lunaria annua L. seeds were analyzed qualitatively and quantitatively by their desulfo counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products, isothiocyanates (ITCs), using GC-MS te…
View article: Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants
Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants Open
The glucosinolates (GSLs) is a well-defined group of plant metabolites characterized by having an S-β-d-glucopyrano unit anomerically connected to an O-sulfated (Z)-thiohydroximate function. After enzymatic hydrolysis, the sulfated aglucon…