Patrick Ruther
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View article: Efficient and sustained optogenetic control of sensory and cardiac systems
Efficient and sustained optogenetic control of sensory and cardiac systems Open
Optogenetic control is used to manipulate the activity of specific cell types in vivo for a variety of biological and clinical applications. Here we report ChReef, an improved variant of the channelrhodopsin ChRmine. ChReef offers minimal …
View article: Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system Open
Objective. In case of deafness, electrical cochlear implants (eCIs) bypass dysfunctional or lost hair cells by direct stimulation of the auditory nerve. However, spectral selectivity of eCI sound coding is low as the wide current spread fr…
View article: Spatially precise activation of the mouse cochlea with a multi-channel hybrid cochlear implant
Spatially precise activation of the mouse cochlea with a multi-channel hybrid cochlear implant Open
Objective. Cochlear implants are among the few clinical interventions for people with severe or profound hearing loss. However, current spread during monopolar electrical stimulation results in poor spectral resolution, prompting the explo…
View article: Dry resist laser patterning of flexible neural probes with fluidic functionality
Dry resist laser patterning of flexible neural probes with fluidic functionality Open
Optogenetics enables insights into the development of neural diseases. Custom-designed neural probes are necessary to access targeted brain regions. Multifunctional and mechanically flexible probes with minimal footprint, comprising fluidi…
View article: Polymer-based laminar probes with an ultra-long flexible spiral-shaped cable for in vivo neural recordings
Polymer-based laminar probes with an ultra-long flexible spiral-shaped cable for in vivo neural recordings Open
Compared to conventional rigid silicon probes, flexible penetrating neural implants exhibit improved mechanical compliance with brain tissue, enabling high-quality neural recordings over extended periods of time. However, the length of the…
View article: High-power-density hybrid planar-type silicon thermoelectric generator with phononic nanostructures
High-power-density hybrid planar-type silicon thermoelectric generator with phononic nanostructures Open
Energy harvesting is essential for the internet-of-things networks where a tremendous number of sensors require power.Thermoelectric generators (TEGs), especially those based on silicon (Si), are a promising source of clean and sustainable…
View article: Editorial: Problems, strategies, and developments for high-density long-term chronic intracortical neural interfaces and their application
Editorial: Problems, strategies, and developments for high-density long-term chronic intracortical neural interfaces and their application Open
Editorial: Problems, strategies, and developments for high-density long-term chronic intracortical neural interfaces and their application
View article: Fraxicon for Optical Applications with Aperture ∼1 mm: Characterisation Study
Fraxicon for Optical Applications with Aperture ∼1 mm: Characterisation Study Open
Emerging applications of optical technologies are driving the development of miniaturised light sources, which in turn require the fabrication of matching micro-optical elements with sub-1 mm cross-sections and high optical quality. This i…
View article: Polymer-Based Laminar Probes with an Ultra-Long Flexible Spiral-Shaped Cable for in Vivo Neural Recordings
Polymer-Based Laminar Probes with an Ultra-Long Flexible Spiral-Shaped Cable for in Vivo Neural Recordings Open
View article: Fraxicon for Optical Applications with Aperture ∼1 mm
Fraxicon for Optical Applications with Aperture ∼1 mm Open
Emerging applications of optical technologies are driving the development of miniaturised light sources, which in turn require the fabrication of matching micro-optical elements with sub-1 mm cross sections and high optical quality. This i…
View article: Efficient and sustained optogenetic control of sensory and cardiac systems
Efficient and sustained optogenetic control of sensory and cardiac systems Open
Optogenetic control is used to manipulate the activity of specific cell types in vivo for a variety of biological and clinical applications. Here we report ChReef, an improved variant of the channelrhodopsin ChRmine. ChReef offers minimal …
View article: Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea
Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea Open
For individuals with severe to profound hearing loss resulting from irreversibly damaged hair cells, cochlear implants can be used to restore hearing by delivering electrical stimulation directly to the spiral ganglion neurons. However, cu…
View article: Planar-type silicon thermoelectric generator with phononic nanostructures for 100 μW energy harvesting
Planar-type silicon thermoelectric generator with phononic nanostructures for 100 μW energy harvesting Open
Energy harvesting is essential for the internet-of-things networks where a tremendous number of sensors require power. Thermoelectric generators (TEGs), especially those based on silicon (Si), are a promising source of clean and sustainabl…
View article: Integration of the <scp>CA2</scp> region in the hippocampal network during epileptogenesis
Integration of the <span>CA2</span> region in the hippocampal network during epileptogenesis Open
The CA2 pyramidal cells are mostly resistant to cell death in mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis, but they are aberrantly integrated into the epileptic hippocampal network via mossy fiber sprouting. Furthermore…
View article: Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation Open
Simultaneous large-scale recordings and optogenetic interventions may hold the key to deciphering the fast-paced and multifaceted dialogue between neurons that sustains brain function. Here we have taken advantage of thin, cell-sized, opti…
View article: Single‐layer tri‐state switching as an economical method to address linear light‐emitting diode arrays
Single‐layer tri‐state switching as an economical method to address linear light‐emitting diode arrays Open
This paper reports on new schemes based on the concept of tri‐state switching for routing linear arrays of light‐emitting diodes (LEDs) on slim substrates. The schemes use a minimal number of wires in single‐metal planar technologies, wher…
View article: Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats
Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats Open
Objective . Optogenetics involves delivery of light-sensitive opsins to the target brain region, as well as introduction of optical and electrical devices to manipulate and record neural activity, respectively, from the targeted neural pop…
View article: Intracortical probe arrays with silicon backbone and microelectrodes on thin polyimide wings enable long-term stable recordings in vivo
Intracortical probe arrays with silicon backbone and microelectrodes on thin polyimide wings enable long-term stable recordings in vivo Open
Objective Recording and stimulating neuronal activity across different brain regions requires interfacing at multiple sites using dedicated tools while tissue reactions at the recording sites often prevent their successful long-term applic…
View article: Etablierung des optogenetischen Kelhkopfschrittmachers im Schweinemodell
Etablierung des optogenetischen Kelhkopfschrittmachers im Schweinemodell Open
Einführung Bilaterale Recurrensparesen führen zu Stimmlippenstillstand und Dyspnoe. Derzeitige Behandlungsoptionen haben massive Nebenwirkungen und auch die elektrische Stimulation technische Limitationen. Wir konnten die direkte optogenet…
View article: A pig model for optogenetic laryngeal pacemaking
A pig model for optogenetic laryngeal pacemaking Open
Introduction Bilateral laryngeal paresis results in fixed vocal cords and diminished air passage. Current treatment options have to take a loss of function and also electrical stimulation faces technical limitations. We were able to show d…
View article: Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats
Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats Open
Objective Optogenetics involves delivery of light-sensitive opsins to the target brain region, as well as introduction of optical and electrical devices to manipulate and record neural activity, respectively, from the targeted neural popul…
View article: Layer-specific stimulations of parvalbumin-positive cortical interneurons in mice entrain brain rhythms to different frequencies
Layer-specific stimulations of parvalbumin-positive cortical interneurons in mice entrain brain rhythms to different frequencies Open
Neocortical interneurons provide inhibition responsible for organizing neuronal activity into brain oscillations that subserve cognitive functions such as memory, attention or prediction. However, little is known about the interneuronal co…
View article: Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation Open
Highlights: To combine large-scale recordings with optical perturbation we have developed a number of new techniques such as thin optical side-emitting fibers, a fiber matrix connector for thin fibers, an electro-optical commutator for mul…
View article: Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings Open
Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investig…
View article: Histological assessment of a chronically implanted cylindrically-shaped, polymer-based neural probe in the monkey
Histological assessment of a chronically implanted cylindrically-shaped, polymer-based neural probe in the monkey Open
Objective. Previous studies demonstrated the possibility to fabricate stereo-electroencephalography probes with high channel count and great design freedom, which incorporate macro-electrodes as well as micro-electrodes offering potential …
View article: Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation Open
Summary Simultaneous large-scale recordings and optogenetic interventions hold the promise to decipher the fast-paced and multifaceted dialogue between neurons that sustains brain function. Here we developed unprecedentedly thin, cell-size…
View article: Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents Open
Optogenetic hearing restoration in rodents by LED-based multichannel optical cochlear implants provides improved spectral selectivity.
View article: μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve Open
View article: Recording site placement on planar silicon-based probes affects neural signal quality: edge sites enhance acute recording performance
Recording site placement on planar silicon-based probes affects neural signal quality: edge sites enhance acute recording performance Open
Objective Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices (e.g. shank thickness, tip geometry) are designed to improve their record…
View article: Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system Open
In case of deafness, electrical cochlear implants (eCIs) bypass dysfunctional or lost hair cells by direct stimulation of the auditory nerve. However, spectral selectivity of eCI sound coding is low as the wide current spread from each ele…