Patrick Ryscavage
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View article: Assessing weight change in adolescents and young adults with perinatally acquired <scp>HIV</scp> and integrase inhibitor use
Assessing weight change in adolescents and young adults with perinatally acquired <span>HIV</span> and integrase inhibitor use Open
Introduction Integrase strand transfer inhibitors (INSTIs) are the mainstay of treatment in adults and children living with HIV. Weight gain has been associated with INSTI use in adults; however, less data exist on its effects on younger p…
View article: CD4+ T‐cell recovery in HIV/hepatitis C co‐infected patients following successful hepatitis C treatment
CD4+ T‐cell recovery in HIV/hepatitis C co‐infected patients following successful hepatitis C treatment Open
Introduction Hepatitis C virus (HCV)/HIV co‐infection has been identified as a risk for impaired CD4+ T‐cell recovery, possibly mediated by HCV‐induced liver fibrosis and/or immune activation. As HCV direct‐acting antivirals (DAAs) may par…
View article: 1589. Real-World Outcomes with Cabotegravir/Rilpivirine: Does Duration of Pre-treatment Viral Suppression Matter?
1589. Real-World Outcomes with Cabotegravir/Rilpivirine: Does Duration of Pre-treatment Viral Suppression Matter? Open
Background The efficacy and safety of long-acting injectable, cabotegravir/rilpivirine (CAB/RPV), was established in people with HIV (PHIV) on a stable oral antiretroviral (ART) regimen with viral suppression ≥ 6 months prior to CAB/RPV in…
View article: Evidence for risk stratification when monitoring for toxicities following initiation of combination antiretroviral therapy
Evidence for risk stratification when monitoring for toxicities following initiation of combination antiretroviral therapy Open
Laboratory monitoring is recommended during combination antiretroviral therapy (cART), but the pattern of detected abnormalities and optimal monitoring are unknown. We assessed laboratory abnormalities during initial cART in 2000–2010 acro…
View article: Hematologic, Hepatic, Renal, and Lipid Laboratory Monitoring After Initiation of Combination Antiretroviral Therapy in the United States, 2000–2010
Hematologic, Hepatic, Renal, and Lipid Laboratory Monitoring After Initiation of Combination Antiretroviral Therapy in the United States, 2000–2010 Open
We assessed laboratory monitoring following combination antiretroviral therapy (cART) initiation among 3,678 patients in a large US multi-site clinical cohort, censoring participants at last clinic visit, cART change, or three years. Media…
View article: Virologic Response, Early HIV-1 Decay, and Maraviroc Pharmacokinetics With the Nucleos(t)ide-Free Regimen of MaravIroc Plus Darunavir/Ritonavir in a Pilot Study
Virologic Response, Early HIV-1 Decay, and Maraviroc Pharmacokinetics With the Nucleos(t)ide-Free Regimen of MaravIroc Plus Darunavir/Ritonavir in a Pilot Study Open
To address the need for nucleos(t)ide reverse transcriptase inhibitor (NRTI)-sparing regimens, we explored the virologic and pharmacokinetic characteristics of maraviroc plus ritonavir-boosted darunavir in a single-arm, open-label, 96-week…
View article: 346. Factors Associated with Hypertension in Young Adults with Perinatally-Acquired HIV Infection: a Case–Control Study
346. Factors Associated with Hypertension in Young Adults with Perinatally-Acquired HIV Infection: a Case–Control Study Open
Background The incidence of systemic hypertension (HTN) among perinatally-HIV-infected (PHIV) patients appears to increase as they enter adulthood. Among non-perinatally HIV-infected adults both traditional and HIV-associated risk factors …
View article: P568 Positivity of syphilis, rectal gonorrhea and rectal chlamydia among MSM PrEP users in baltimore city, maryland
P568 Positivity of syphilis, rectal gonorrhea and rectal chlamydia among MSM PrEP users in baltimore city, maryland Open
Background Bacterial STIs such as syphilis, rectal gonorrhea (GC) and chlamydia (CT) are strongly associated with increased risk of HIV acquisition, and are a marker of ongoing sexual risk behavior among HIV pre-exposure prophylaxis (PrEP)…
View article: O10.5 Patterns of HIV pre-exposure prophylaxis care one year after initiating PrEP, baltimore city, maryland 2015–2018
O10.5 Patterns of HIV pre-exposure prophylaxis care one year after initiating PrEP, baltimore city, maryland 2015–2018 Open
Background Persistent HIV pre-exposure prophylaxis (PrEP) use is critical to preventing HIV acquisition. U.S. Centers for Disease Control and Prevention (CDC) recommends quarterly clinical evaluation for individuals using PrEP. Individual-…
View article: Interest of Youth Living With HIV in Long-Acting Antiretrovirals
Interest of Youth Living With HIV in Long-Acting Antiretrovirals Open
Objectives: This study's primary objective was to characterize attitudes to long-acting antiretrovirals (LAARV), among youth aged 13–24 years living with perinatally acquired HIV and nonperinatally acquired HIV. Secondary objectives includ…
View article: HIV healthcare transition outcomes among youth in North America and Europe: a review
HIV healthcare transition outcomes among youth in North America and Europe: a review Open
Introduction : The transition from paediatric to adult care poses risks to the health of young adults living with HIV if unsuccessful, including interruptions in care and poor health outcomes. Evolving best practices in HIV healthcare tran…
View article: Prevalence of Systemic Hypertension Among HIV-Infected and HIV-Uninfected Young Adults
Prevalence of Systemic Hypertension Among HIV-Infected and HIV-Uninfected Young Adults Open
Background Advances in HIV care and treatment have resulted in perinatally infected children aging into adulthood. These patients may be at higher risk of HIV-associated non-AIDS conditions, including systemic hypertension (HTN). This stud…
View article: Patterns of Systemic Hypertension among Adults with Perinatally Acquired HIV
Patterns of Systemic Hypertension among Adults with Perinatally Acquired HIV Open
Patients with perinatally acquired HIV may be at risk for the development of age-related non-AIDS diseases. The primary aim of this study was to describe patterns of systemic hypertension among a cohort of adults (≥18 years) with perinatal…
View article: Galactomannan antigen detection using bronchial wash and bronchoalveolar lavage in patients with hematologic malignancies
Galactomannan antigen detection using bronchial wash and bronchoalveolar lavage in patients with hematologic malignancies Open
This retrospective study examining two collection techniques suggests that BW may have higher diagnostic yield compared to bronchoalveolar lavage for GM detection.
View article: Contemporary issues on the epidemiology and antiretroviral adherence of HIV‐infected adolescents in sub‐Saharan Africa: a narrative review
Contemporary issues on the epidemiology and antiretroviral adherence of HIV‐infected adolescents in sub‐Saharan Africa: a narrative review Open
Introduction Adolescents are a unique and sometimes neglected group in the planning of healthcare services. This is the case in many parts of sub‐Saharan Africa, where more than eight out of ten of the world's HIV‐infected adolescents live…