Patrick Chen
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Systemic Challenges to Lung Cancer Screening in the Safety-Net Setting: Care and Informatics Fragmentation Open
Care and informatics fragmentation particularly deplete safety-net resources and cause organized cancer screening programs to be unduly labor-intensive in this setting. These challenges were prevalent even in well-established screening pro…
Whole blood transfusion in pediatric trauma patients with traumatic brain injury may decrease the risk of early death Open
Objective There has been a resurgence in the use of whole blood for trauma resuscitation, however the outcomes for pediatric trauma patients with traumatic brain injury (TBI) resuscitated with whole blood are unknown. We hypothesized a low…
Association Between Stimulant Medication Use in Attention-Deficit/Hyperactivity Disorder (ADHD) and the Increased Risk of Upper Respiratory Tract Infections: A Retrospective Study Open
Introduction Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that can persist from childhood into adulthood. Stimulant medications such as methylphenidate and amphetamine derivatives are the mainsta…
View article: The mouse pangenome reveals the structural complexity of the murine protein-coding landscape
The mouse pangenome reveals the structural complexity of the murine protein-coding landscape Open
We present the first mouse pangenome consisting of 17 high-quality inbred mouse strain genomes with complete annotation. This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We have fully resolve…
View article: Development of the <scp>KeyStrokes</scp> test: An online neuropsychological assessment for attention, processing speed and executive function
Development of the <span>KeyStrokes</span> test: An online neuropsychological assessment for attention, processing speed and executive function Open
The ‘KeyStrokes’ test (KS) was created as an online and computerized neuropsychological assessment to assess simple attention, processing speed, and executive function. This pilot study aims to show proof of concept of the KS test as a com…
Seeing and Seeing Through the Glass: Real and Synthetic Data for Multi-Layer Depth Estimation Open
Transparent objects are common in daily life, and understanding their multi-layer depth information -- perceiving both the transparent surface and the objects behind it -- is crucial for real-world applications that interact with transpare…
View article: Field-angle evolution of the superconducting and magnetic phases of UTe$_2$ around the $b$ axis
Field-angle evolution of the superconducting and magnetic phases of UTe$_2$ around the $b$ axis Open
We experimentally determine the bounds of the magnetic-field-induced superconducting and magnetic phases near the crystalline $b$ axis of uranium ditelluride (UTe$_2$). By measuring the magnetoresistance as a function of rotation angle and…
View article: iPad-Based Neurocognitive Testing (ImPACT-QT) in Acute Adult Mild Traumatic Brain Injury/Concussion: Study on Practicality and Bedside Cognitive Scores in a Level-1 Trauma Center
iPad-Based Neurocognitive Testing (ImPACT-QT) in Acute Adult Mild Traumatic Brain Injury/Concussion: Study on Practicality and Bedside Cognitive Scores in a Level-1 Trauma Center Open
Background There lacks rapid standardized bedside testing to screen cognitive deficits following mild traumatic brain injury (mTBI). Immediate Post-Concussion Assessment & Cognitive Testing-Quick Test (ImPACT-QT) is an abbreviated-iPad for…
View article: 574: GRADE 3 DAI IN TBI DOES NOT PREDICT NEED FOR TRACHEOSTOMY, GASTROSTOMY, OR DISCHARGE OUTCOME
574: GRADE 3 DAI IN TBI DOES NOT PREDICT NEED FOR TRACHEOSTOMY, GASTROSTOMY, OR DISCHARGE OUTCOME Open
Introduction: Diffuse Axonal Injury (DAI) on MRI, graded by topographic severity from Grade 1 to 3, is a common finding in traumatic brain injury (TBI). The relationship between DAI severity and need for tracheostomy (trach) and percutaneo…
Cerebral microdialysis demonstrates improvements in brain metabolism with cerebrospinal fluid diversion in spontaneous intracerebral hemorrhage Open
Background: Cerebral microdialysis (CMD) is an FDA-approved multimodal invasive monitoring technique that provides local brain metabolism measurements through continuous interstitial brain fluid sampling at the bedside. The past applicatio…
Fast and Accurate Factual Inconsistency Detection Over Long Documents Open
Generative AI models exhibit remarkable potential; however, hallucinations across various tasks present a significant challenge, particularly for longer inputs that current approaches struggle to address effectively. We introduce SCALE (So…
Association of Epileptiform Activity With Outcomes in Toxic-Metabolic Encephalopathy Open
IMPORTANCE: The clinical significance of epileptiform abnormalities (EAs) specific to toxic-metabolic encephalopathy (TME) is unknown. OBJECTIVES: To quantify EA burden in patients with TME and its association with neurologic outcomes. DES…
Supplementary Table 1 from Antitumor Activity of an Oncolytic Adenovirus-Delivered Oncogene Small Interfering RNA Open
Supplementary Table 1 from Antitumor Activity of an Oncolytic Adenovirus-Delivered Oncogene Small Interfering RNA
Supplementary Table 1 from Antitumor Activity of an Oncolytic Adenovirus-Delivered Oncogene Small Interfering RNA Open
Supplementary Table 1 from Antitumor Activity of an Oncolytic Adenovirus-Delivered Oncogene Small Interfering RNA
Data from Antitumor Activity of an Oncolytic Adenovirus-Delivered Oncogene Small Interfering RNA Open
Despite successes in animal models, cancer gene therapy with small interfering RNAs (siRNA) is hindered by the lack of an optimal delivery platform. We examined the applicability of the replication-competent, oncolytic adenovirus, ONYX-411…
Abstract Number ‐ 113: A Lateral Medullary Infarct Complicated by Central Hypoventilation Syndrome Open
Introduction A 43‐year‐old male with no known past medical history presented to a primary stroke center for sudden onset headache, nausea, vomiting, and dizziness while driving. A computed tomography angiogram of the head and neck revealed…
Fast and Accurate Factual Inconsistency Detection Over Long Documents Open
Generative AI models exhibit remarkable potential; however, hallucinations across various tasks present a significant challenge, particularly for longer inputs that current approaches struggle to address effectively. We introduce SCALE (So…
Excel Spreadsheet Analyzer Open
Spreadsheets are widely used in various fields to do large numerical analysis. While several companies have relied on spreadsheets for decades, data scientists are going in the direction of using scientific programming languages such as py…
View article: Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders
Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders Open
These findings suggest that TBI of any severity was associated with a higher risk of chronic cardiovascular, endocrine, and neurological comorbidities in patients without baseline diagnoses. Medical comorbidities were observed in relativel…
The impact and restoration of colorectal services during the <span>coronavirus disease 20</span>19 pandemic: A view from <span>Oxford</span> Open
Aim The coronavirus pandemic has significantly disrupted the way we deliver healthcare worldwide. We have been flexible and creative in order to continue providing elective colorectal cancer operations and to restart services for benign ca…
Generalized periodic discharges with triphasic morphology: to treat or not to treat? Open
We report an 82-year-old woman with recurring episodes of confusion, a left posterior fossa meningioma, and chronic hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH).She presented with a habitual episode …