Patrick Scheid
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View article: Repurposing Analysis of Nitroxoline (8-Hydroxy-5-nitroquinoline) as an Antichagasic Compound
Repurposing Analysis of Nitroxoline (8-Hydroxy-5-nitroquinoline) as an Antichagasic Compound Open
Background/Objectives: Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a major neglected tropical disease, with over six million cases concentrated, primarily in Latin America. Despite decades of research, treat…
View article: Additional Investigations of UV-C Irradiation Schemes for Viral Decontamination of FFP2 Masks
Additional Investigations of UV-C Irradiation Schemes for Viral Decontamination of FFP2 Masks Open
The reprocessing of personal protective equipment that is only intended for single use has been brought into focus by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, especially regarding respiratory masks. 1 – 4
View article: Investigation of Three Different UV-C Irradiation Schemes for Bacterial Decontamination of FFP2 Masks to Make Them Reusable
Investigation of Three Different UV-C Irradiation Schemes for Bacterial Decontamination of FFP2 Masks to Make Them Reusable Open
The effect of filtering face piece grade 2 (FFP2) masks for infection prevention is essential in health care systems; however, it depends on supply chains. Efficient methods to reprocess FFP2 masks may be needed in disasters. Therefore, di…
View article: Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline
Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline Open
Acanthamoeba is a ubiquitous genus of amoebae that can act as opportunistic parasites in both humans and animals, causing a variety of ocular, nervous and dermal pathologies. Despite advances in Acanthamoeba therapy, the management of pati…
View article: Repurposing of Nitroxoline as an Alternative Primary Amoebic Meningoencephalitis Treatment
Repurposing of Nitroxoline as an Alternative Primary Amoebic Meningoencephalitis Treatment Open
Among the pathogenic free-living amoebae (FLA), Naegleria fowleri is the etiological agent of a fatal disease known as primary amoebic meningoencephalitis (PAM). Once infection begins, the lesions generated in the central nervous system (C…
View article: Biosensors supporting healthcare in missions — expert consensus on the status of implementation in the military and future tasks
Biosensors supporting healthcare in missions — expert consensus on the status of implementation in the military and future tasks Open
The monitoring of physiological parameters using wearable (bio-) sensors of military personnel is a progressing process within the military environment. It sets high demands on such devices, in order to support healthcare and performance o…
View article: Component Endoparasite Communities Mirror Life-History Specialization in Syntopic Reed Frogs (Hyperolius spp.)
Component Endoparasite Communities Mirror Life-History Specialization in Syntopic Reed Frogs (Hyperolius spp.) Open
Most of our knowledge on the processes structuring parasite communities in amphibians originate from temperate-zone taxa, whereas Afrotropical communities have been neglected so far. We found evidence that ecological fitting of the hosts a…
View article: Comparison of Three In-House Real PCR Assays Targeting Kinetoplast DNA, the Small Subunit Ribosomal RNA Gene and the Glucose-6-Phosphate Isomerase Gene for the Detection of Leishmania spp. in Human Serum
Comparison of Three In-House Real PCR Assays Targeting Kinetoplast DNA, the Small Subunit Ribosomal RNA Gene and the Glucose-6-Phosphate Isomerase Gene for the Detection of Leishmania spp. in Human Serum Open
To perform PCR from serum for the diagnosis of visceral leishmaniasis is convenient and much less invasive than the examination of deeper compartments such as bone marrow. We compared three Leishmania-specific real-time PCRs with three dif…
View article: Alternative Development Strategies of Clinostomum chabaudi (Digenea) Metacercariae in Frog Hosts (Hyperolius spp.)
Alternative Development Strategies of Clinostomum chabaudi (Digenea) Metacercariae in Frog Hosts (Hyperolius spp.) Open
Clinostomum metacercariae are common endoparasites of fish and frogs. In this study, we examine taxonomic identity and developmental strategy of Clinostomum metacercariae infesting reed frogs Hyperolius kivuensis and H. viridiflavus in Rwa…
View article: Molecular Diversity of Nematode Parasites in Afrotropical Reed Frogs (Hyperolius spp.)
Molecular Diversity of Nematode Parasites in Afrotropical Reed Frogs (Hyperolius spp.) Open
The diversity of nematodes infecting amphibians is understudied in tropical Africa and unknown in Rwanda. Diversity assessment is hampered by the fact that species descriptions refer mostly to morphological features that are unlinked to DN…
View article: Vermamoeba vermiformis - A Free-Living Amoeba with Public Health and Environmental Health Significance
Vermamoeba vermiformis - A Free-Living Amoeba with Public Health and Environmental Health Significance Open
Many case reports emphasize the fact that Free-Living Amoebae (FLA) can relatively easily get in contact with humans or animals. The presence of several facultative parasitic FLA in habitats related to human activities supports their publi…
View article: Amoebophagous Fungi as Predators and Parasites of Potentially Pathogenic Free-living Amoebae
Amoebophagous Fungi as Predators and Parasites of Potentially Pathogenic Free-living Amoebae Open
There are numerous case reports indicating that naked Free-Living Amoebae (FLA) can relatively easily get to humans or animals. The presence of pathogenic amoebae in habitats related to human activities supports the public health relevance…
View article: New Insights into the Interaction of Free-Living Amoebae and Pandoravirus Inopinatum: Investigations of the Host Range and the Role of Multilamellar Bodies
New Insights into the Interaction of Free-Living Amoebae and Pandoravirus Inopinatum: Investigations of the Host Range and the Role of Multilamellar Bodies Open
Objective: FLA are predatory heterotrophic microorganisms, feeding as trophozoites on bacteria, cyanobacteria, fungi and algae while adhering to surfaces through phagocytosis. It is known that FLA produce and expel vesicles as part of the …
View article: Free-Living Amoebae as Human Parasites and Hosts for Pathogenic Microorganisms
Free-Living Amoebae as Human Parasites and Hosts for Pathogenic Microorganisms Open
Free-living amoebae (FLA) can be found both in natural aquatic environments and in artificial, man-made aquatic environments. For a long time, (naked) FLA were considered to be harmless protozoa of soil and water. However, research since t…
View article: Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance
Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance Open
Free-living amoebae (FLA) are parasites within both humans and animals causing a wide range of symptoms and act as hosts of, and vehicles for phylogenetically diverse microorganisms, called endocytobionts. The interaction of the FLA with s…