Patrick J. Schuler
YOU?
Author Swipe
View article: Quality of Life After Surgical Treatment of Head and Neck Paragangliomas
Quality of Life After Surgical Treatment of Head and Neck Paragangliomas Open
Background Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors and often arise in the head and neck. Due to their localization, the tumor and its surgical treatment pose a risk for cranial nerve impairments. Few studies ha…
View article: Identification of marginal zone B cells in head and neck cancer with immunomodulatory characteristics
Identification of marginal zone B cells in head and neck cancer with immunomodulatory characteristics Open
Our findings demonstrate an immunomodulatory role of MZBs in tumor immunity, balancing antigen presentation, cytokine signaling, and immune suppression. The association of MZB-2 with improved prognosis in early-stage HNSCC highlights its p…
View article: Different immunotherapeutic combinations enhance specific T cell immune responses against leukemic cells, as well as leukemic progenitor cells, in acute myeloid leukemia
Different immunotherapeutic combinations enhance specific T cell immune responses against leukemic cells, as well as leukemic progenitor cells, in acute myeloid leukemia Open
Immunotherapeutic approaches have become increasingly important in cancer therapy, including for patients with acute myeloid leukemia (AML). Despite being shown to be effective in the context of stem cell transplants for almost 50 years, f…
View article: Co-Stimulatory and Immune Checkpoint Molecule Expression on Peripheral Immune Cells Differs Age Dependently Between Healthy Donors and Patients with Head and Neck Squamous Cell Carcinoma
Co-Stimulatory and Immune Checkpoint Molecule Expression on Peripheral Immune Cells Differs Age Dependently Between Healthy Donors and Patients with Head and Neck Squamous Cell Carcinoma Open
Introduction: The analysis of exhaustion marker expression, like immune checkpoint molecules (ICMs) on tumor-infiltrating lymphocytes as well as peripheral immune cells of patients with head and neck squamous cell carcinoma (HNSCC), is of …
View article: Randomized controlled trial of semi-individualized 3D-printed tissue retraction devices vs. standard shielding splints in head and neck cancer treated with intensity-modulated and particle radiotherapy (GUARD)
Randomized controlled trial of semi-individualized 3D-printed tissue retraction devices vs. standard shielding splints in head and neck cancer treated with intensity-modulated and particle radiotherapy (GUARD) Open
NCT04454697.
View article: A recurrence analysis in patients with congenital choanal atresia
A recurrence analysis in patients with congenital choanal atresia Open
Recurrences following congenital choanal atresia (CA) repair are a particular challenge. This study sought to investigate the underlying causes of recurrences. The study compared 33 primary surgeries (controls, median age 32 months) to 34 …
View article: Different Immunotherapeutic Combinations Enhance Specific T Cell Immune Responses Against Leukemic Cells, as well as Leukemic Progenitor and Stem Cells, in Acute Myeloid Leukemia
Different Immunotherapeutic Combinations Enhance Specific T Cell Immune Responses Against Leukemic Cells, as well as Leukemic Progenitor and Stem Cells, in Acute Myeloid Leukemia Open
Immunotherapeutic approaches have become increasingly important in cancer therapy, including for patients with acute myeloid leukaemia (AML). Despite being shown to be effective in the context of stem cell transplants for almost 50 years, …
View article: Exploratory assessment of an endolaryngeal surgical model with a novel hyperangulated 3D printed laryngoscope
Exploratory assessment of an endolaryngeal surgical model with a novel hyperangulated 3D printed laryngoscope Open
View article: A Comparative Evaluation of Three Different Attachment Methods for a Video Laryngoscope in a Surgical Setting
A Comparative Evaluation of Three Different Attachment Methods for a Video Laryngoscope in a Surgical Setting Open
Introduction The prerequisite for transoral microsurgery of laryngeal lesions is an uninterrupted line of sight to the operative field. Patients with cervical stiffness or anatomical variations that prevent adequate laryngeal exposure are …
View article: Rezension von: Schuler, Peter-Johannes, Geschichte des südwestdeutschen Notariats
Rezension von: Schuler, Peter-Johannes, Geschichte des südwestdeutschen Notariats Open
Peter-Johannes Schuler: Geschichte des südwestdeutschen Notariats von seinen Anfängen bis zur Reichsnotariatsordnung von 1512. Verlag Konkordia Bühl (Baden) 1976. 362 Seiten.
View article: Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC
Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC Open
Patients with head and neck squamous cell carcinoma (HNSCC) suffer from severe morbidity and mortality. Immunotherapy represents a novel promising treatment option. Therefore, a better understanding of the immune niche is needed. This stud…
View article: Ligand-receptor interactions combined with histopathology for improved prognostic modeling in HPV-negative head and neck squamous cell carcinoma
Ligand-receptor interactions combined with histopathology for improved prognostic modeling in HPV-negative head and neck squamous cell carcinoma Open
View article: Enhancing surgical precision in squamous cell carcinoma of the head and neck: Hyperspectral imaging and artificial intelligence for improved margin assessment in an ex vivo setting
Enhancing surgical precision in squamous cell carcinoma of the head and neck: Hyperspectral imaging and artificial intelligence for improved margin assessment in an ex vivo setting Open
Hyperspectral imaging, complemented by AI, shows promise in enhancing tissue differentiation for HNSCC. The study envisions real-time integration of HSI into surgery for margin assessment. Challenges such as data volume and capture times w…
View article: Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease
Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease Open
View article: Randomized Controlled Trial of Semi-Individualized 3d-Printed Tissue Retraction Devices vs. Conventional Splints in Head and Neck Cancer Treated with Intensity-Modulated and Particle Radiotherapy (Guard)
Randomized Controlled Trial of Semi-Individualized 3d-Printed Tissue Retraction Devices vs. Conventional Splints in Head and Neck Cancer Treated with Intensity-Modulated and Particle Radiotherapy (Guard) Open
View article: Identification of B Cell Subpopulations with Pro- and Anti-Tumorigenic Properties in an Immunocompetent Mouse Model of Head and Neck Squamous Cell Carcinoma
Identification of B Cell Subpopulations with Pro- and Anti-Tumorigenic Properties in an Immunocompetent Mouse Model of Head and Neck Squamous Cell Carcinoma Open
Due to their high developmental diversity and different regulatory and functional roles, B cell subpopulations can promote or inhibit tumor growth. An orthotopic murine HNSCC model was applied to investigate the B cell composition and func…
View article: 5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD4 T cells
5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD4 T cells Open
Failure of immunotherapy in head and neck squamous cell carcinoma (HNSCC) patients represents an unmet need to augment leverage of adaptive immunity. Immunogenic cancer-testis antigen (CTA) expression as well as lymphocyte differentiation …
View article: Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) – A single-cell RNA sequencing analysis
Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) – A single-cell RNA sequencing analysis Open
View article: Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia
Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a malignant disease of the blood and bone marrow that is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Nucleophosmin 1 (NPM1) gene mutations are the most common gen…
View article: Bending the rules: A novel approach to laryngeal surgery in a body donor study
Bending the rules: A novel approach to laryngeal surgery in a body donor study Open
Background Transoral laser microsurgery, the standard surgical approach for early‐stage laryngeal cancer, necessitates an unobstructed line of sight to the operating field. However, achieving adequate laryngeal exposure can be challenging,…
View article: Intraoperative use of virtual reality decreases anxiety during surgery under local anaesthesia in the head and neck region
Intraoperative use of virtual reality decreases anxiety during surgery under local anaesthesia in the head and neck region Open
The availability of virtual reality (VR) in the medical field has been rapidly increasing in the past years. Here we investigate to which extent the VR headset can lead to a reduction in anxiety and pain in patients during surgical procedu…
View article: A Laryngoscope with Shape Memory Actuation
A Laryngoscope with Shape Memory Actuation Open
Endotracheal intubation is a medical procedure to secure a patient’s airways, which can be challenging in emergency situations due to an individual’s anatomy. Intubation blades can benefit from an adjustable design with shape memory alloys…
View article: Barbed suture in neck dissection: a randomized clinical study on efficacy, safety and aesthetic outcome
Barbed suture in neck dissection: a randomized clinical study on efficacy, safety and aesthetic outcome Open
View article: A phase I trial of LHC165 single agent and in combination with spartalizumab in patients with advanced solid malignancies
A phase I trial of LHC165 single agent and in combination with spartalizumab in patients with advanced solid malignancies Open
LHC165 demonstrated acceptable safety and tolerability both as SA and in combination with spartalizumab, and evidence of limited antitumor activity was seen in adult patients with relapsed/refractory or metastatic solid tumors.
View article: Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens
Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens Open
Introduction The human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T cells. Overexpressed tumor associated antigens, mainly cancer-testis an…
View article: Immunotherapeutic Potential of Mutated NPM1 for the Treatment of AML
Immunotherapeutic Potential of Mutated NPM1 for the Treatment of AML Open
Acute myeloid leukemia (AML) is a malignant disease of the blood and bone marrow that is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Nucleophosmin 1 (NPM1) gene mutations are the most common gen…
View article: Supplementary Table 1 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression
Supplementary Table 1 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression Open
Gene set enrichment analysis output
View article: FIGURE 6 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression
FIGURE 6 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression Open
Cell death upon INHBA knockdown. A, Cell death of native UDSCC1, Mock KD, INHBA KD1/KD2 and native UDSCC2 cells as assessed by Annexin V/7-AAD staining and flow cytometry. Results are shown as mean ± SD of the percenta…
View article: TABLE 1 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression
TABLE 1 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression Open
Clinicopathologic features of patients with OPSCC in Ulm and TCGA cohorts
View article: TABLE 1 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression
TABLE 1 from <i>INHBA</i> is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression Open
Clinicopathologic features of patients with OPSCC in Ulm and TCGA cohorts