Patrick Seale
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View article: The innate thermogenic capacity of brown adipose tissue develops independently of sympathetic signaling
The innate thermogenic capacity of brown adipose tissue develops independently of sympathetic signaling Open
Brown adipose tissue (BAT) dissipates energy as heat in response to β-adrenergic signaling induced by the sympathetic nervous system (SNS). While this pathway is essential for the cold-induced remodeling and metabolic activity of BAT, its …
View article: The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation
The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation Open
The transcription factor CUX1 regulates adipocyte differentiation in opposite directions in humans and mice, emphasizing the need for species-specific models in metabolic disease research.
View article: PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition Open
Vascular smooth muscle cells (SMCs) undergo phenotype switching to acquire various fates in response to pathological stimuli. Among these, ‘synthetic’ SMCs—defined by migration, proliferation and extracellular matrix production—accumulate …
View article: PRDM16 controls smooth muscle cell fate in atherosclerosis
PRDM16 controls smooth muscle cell fate in atherosclerosis Open
Summary Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to pathologic stimuli 1–3 . In atherosclerosis, these phenotypically modulated …
View article: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity Open
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome…
View article: Transcriptional regulation of adipocyte lipolysis by IRF2BP2
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 Open
Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by posttranslational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate li…
View article: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity Open
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome…
View article: 3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility Open
Genome-wide association studies (GWAS) have identified genetic links to autoimmune disorders, but lack detail on causal elements. We generated 3D genomic datasets of promoter-focused Capture-C, Hi-C, ATAC-seq, and RNA-seq across 57 human c…
View article: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity Open
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome…
View article: Author response: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
Author response: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity Open
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome…
View article: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity Open
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome…
View article: Transcriptional regulation of adipocyte lipolysis by IRF2BP2
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 Open
Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by post-translational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate l…
View article: Shared and unique 3D genomic features of substance use disorders across multiple cell types
Shared and unique 3D genomic features of substance use disorders across multiple cell types Open
Recent genome-wide association studies (GWAS) revealed shared genetic components among substance use disorders (SUDs). However, the extent of underlying shared causal variants, effector genes, and cellular contexts, remain unclear. We inte…
View article: Early B-cell transcription factor-2 defect as a novel cause of lipodystrophy: disruption of the adipose tissue character and integrity
Early B-cell transcription factor-2 defect as a novel cause of lipodystrophy: disruption of the adipose tissue character and integrity Open
Summary We report a novel cause of partial lipodystrophy associated with early B cell factor 2 ( EBF2 ) nonsense variant ( EBF2 8:26033143 C>A, c.493G>T, p.E165X) in a patient with an atypical form of partial lipodystrophy. The patient pre…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Author Response: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Author Response: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism
Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism Open
Collectively, these data demonstrate that blockade of ActRII signaling improves body composition and metabolic parameters during calorie deficit driven by GLP-1 receptor agonism and demonstrate the existence of Akt-independent pathways sup…
View article: Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis
Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis Open
Osteoarthritis (OA) affects multiple tissues in the knee joint, including the synovium and intra-articular adipose tissue (IAAT) that are attached to each other. However, whether these two tissues share the same progenitor cells and hence …
View article: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity Open
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP Open
Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis 1 . Aside from cAMP signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood. Here, we show that coordi…